Entry
Name
CoA-glutathione reductase;
coenzyme A glutathione disulfide reductase;
NADPH-dependent coenzyme A-SS-glutathione reductase;
coenzyme A disulfide-glutathione reductase;
NADPH:CoA-glutathione oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
glutathione:NADP+ oxidoreductase (CoA-acylating)
Reaction(IUBMB)
CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+ [RN:
R05714 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein. The substrate is a mixed disulfide. May be identical to EC
1.8.1.9 , thioredoxin-disulfide reductase.
History
EC 1.8.1.10 created 1972 as EC 1.6.4.6, transferred 2002 to EC 1.8.1.10
Pathway
ec00270 Cysteine and methionine metabolism
Reference
Authors
Ondarza RN, Abney R, Lopez-Colome AM.
Title
Characterization of a NADPH-dependent coenzyme A-SS-glutathione reductase from yeast.
Journal
Reference
Authors
Ondarza RN, Escamilla E, Gutierrez J, De la Chica G.
Title
CoAS-Sglutathione and GSSG reductases from rat liver. Two disulfide oxidoreductase activities in one protein entity.
Journal
Reference
Authors
Carlberg I, Mannervik B.
Title
Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.8.1.10
ExPASy - ENZYME nomenclature database: 1.8.1.10