KEGG ENZYME: 1.8.1.21

ENZYME: 1.8.1.21

Entry

EC 1.8.1.21                 Enzyme

Name

dissimilatory dimethyldisulfide reductase

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor

Sysname

methanethiol:NAD+ oxidoreductase (dimethyl disulfide-forming)

Reaction(IUBMB)

2 methanethiol + NAD+ = dimethyl disulfide + NADH + H+ [RN:R12457]

Reaction(KEGG)

R12457

Substrate

methanethiol [CPD:C00409];
NAD+ [CPD:C00003]

Product

dimethyl disulfide [CPD:C08371];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme's activity has been demonstrated in the bacterium Thiobacillus thioparus E6. The methanethiol formed is eventually oxidized to sulfate and carbon dioxide, and the latter assimilated for autotrophic growth.

History

EC 1.8.1.21 created 2019

Reference

Authors

Smith, N. A. and Kelly, D. P.

Title

Isolation and physiological characterization of authotrophic sulphur bacteria oxidizing dimethyldisulphide as sole source of energy.

Journal

J Gen Microbiol 134:1407-1417 (1988)

Reference

Authors

Smith, N. A. and Kelly, D. P.

Title

Mechanism of oxidation of dimethyl disulphide by Thiobacillus thioparus E6.

Journal

J Gen Microbiol 134:3031-3039 (1988)

Other DBs

ExplorEnz - The Enzyme Database:

1.8.1.21

IUBMB Enzyme Nomenclature:

1.8.1.21

ExPASy - ENZYME nomenclature database:

1.8.1.21

BRENDA, the Enzyme Database:

1.8.1.21

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG REACTION (1)   
All databases (6)   

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