KEGG ENZYME: 1.8.2.4

ENZYME: 1.8.2.4

Entry

EC 1.8.2.4                  Enzyme

Name

dimethyl sulfide:cytochrome c2 reductase;
Ddh (gene name)

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With a cytochrome as acceptor

Sysname

dimethyl sulfide:cytochrome-c2 oxidoreductase

Reaction(IUBMB)

dimethyl sulfide + 2 ferricytochrome c2 + H2O = dimethyl sulfoxide + 2 ferrocytochrome c2 + 2 H+ [RN:R09500]

Reaction(KEGG)

R09500

Substrate

dimethyl sulfide [CPD:C00580];
ferricytochrome c2 [CPD:C00997];
H2O [CPD:C00001]

Product

dimethyl sulfoxide [CPD:C11143];
ferrocytochrome c2 [CPD:C01000];
H+ [CPD:C00080]

Comment

The enzyme from the bacterium Rhodovulum sulfidophilum binds molybdopterin guanine dinucleotide, heme b and [4Fe-4S] clusters.

History

EC 1.8.2.4 created 2011

Pathway

ec00920

Sulfur metabolism

ec01100

Metabolic pathways

Orthology

K16964

dimethylsulfide dehydrogenase subunit alpha

Genes

HPIS:

P1P91_13995

RSU:

NHU_00476

Reference

1 [PMID:8706745]

Authors

Hanlon SP, Toh TH, Solomon PS, Holt RA, McEwan AG

Title

Dimethylsulfide:acceptor oxidoreductase from Rhodobacter sulfidophilus. The purified enzyme contains b-type haem and a pterin molybdenum cofactor.

Journal

Eur J Biochem 239:391-6 (1996)
DOI:10.1111/j.1432-1033.1996.0391u.x

Sequence

[ag:AAN46632]

Reference

2 [PMID:12067345]

Authors

McDevitt CA, Hugenholtz P, Hanson GR, McEwan AG

Title

Molecular analysis of dimethyl sulphide dehydrogenase from Rhodovulum sulfidophilum: its place in the dimethyl sulphoxide reductase family of microbial molybdopterin-containing enzymes.

Journal

Mol Microbiol 44:1575-87 (2002)
DOI:10.1046/j.1365-2958.2002.02978.x

Sequence

[ag:AAN46632]

Other DBs

ExplorEnz - The Enzyme Database:

1.8.2.4

IUBMB Enzyme Nomenclature:

1.8.2.4

ExPASy - ENZYME nomenclature database:

1.8.2.4

BRENDA, the Enzyme Database:

1.8.2.4

DBGET integrated database retrieval system