KEGG ENZYME: 1.8.4.13

ENZYME: 1.8.4.13

Entry

EC 1.8.4.13                 Enzyme

Name

L-methionine (S)-S-oxide reductase;
fSMsr;
methyl sulfoxide reductase I and II;
acetylmethionine sulfoxide reductase;
methionine sulfoxide reductase;
L-methionine:oxidized-thioredoxin S-oxidoreductase;
methionine-S-oxide reductase;
free-methionine (S)-S-oxide reductase

Class

Oxidoreductases;
Acting on a sulfur group of donors;
With a disulfide as acceptor

Sysname

L-methionine:thioredoxin-disulfide S-oxidoreductase

Reaction(IUBMB)

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin [RN:R07606]

Reaction(KEGG)

R07606;
(other) R02025

Substrate

L-methionine [CPD:C00073];
thioredoxin disulfide [CPD:C00343];
H2O [CPD:C00001]

Product

L-methionine (S)-S-oxide [CPD:C15999];
thioredoxin [CPD:C00342]

Comment

Requires NADPH [2]. The reaction occurs in the opposite direction to that given above. Dithiothreitol can replace reduced thioredoxin. L-Methionine (R)-S-oxide is not a substrate [see EC 1.8.4.14, L-methionine (R)-S-oxide reductase].

History

EC 1.8.4.13 created 1984 as EC 1.8.4.5, part transferred 2006 to EC 1.8.4.13

Pathway

ec00270

Cysteine and methionine metabolism

Reference

Authors

Black, S., Harte, E.M., Hudson, B. and Wartofsky, L.

Title

A specific enzymatic reduction of L-(-)methionine sulfoxide and a related nonspecific reduction of diulfides.

Journal

J Biol Chem 235:2910-2916 (1960)

Reference

2 [PMID:37234]

Authors

Ejiri SI, Weissbach H, Brot N.

Title

Reduction of methionine sulfoxide to methionine by Escherichia coli.

Journal

J Bacteriol 139:161-4 (1979)
DOI:10.1128/JB.139.1.161-164.1979

Reference

3 [PMID:6999943]

Authors

Ejiri SI, Weissbach H, Brot N.

Title

The purification of methionine sulfoxide reductase from Escherichia coli.

Journal

Anal Biochem 102:393-8 (1980)
DOI:10.1016/0003-2697(80)90173-6

Reference

4 [PMID:15680228]

Authors

Weissbach H, Resnick L, Brot N.

Title

Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage.

Journal

Biochim Biophys Acta 1703:203-12 (2005)
DOI:10.1016/j.bbapap.2004.10.004

Other DBs

ExplorEnz - The Enzyme Database:

1.8.4.13

IUBMB Enzyme Nomenclature:

1.8.4.13

ExPASy - ENZYME nomenclature database:

1.8.4.13

BRENDA, the Enzyme Database:

1.8.4.13

DBGET integrated database retrieval system