Entry
Name
eukaryotic sulfide quinone oxidoreductase;
SQR;
SQOR;
SQRDL (gene name)
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
sulfide:glutathione,quinone oxidoreductase
Reaction(IUBMB)
hydrogen sulfide + glutathione + a quinone = S-sulfanylglutathione + a quinol [RN:
R11929 ]
Reaction(KEGG)
Substrate
Product
Comment
Contains FAD. This eukaryotic enzyme, located at the inner mitochondrial membrane, catalyses the first step in the metabolism of sulfide. While both sulfite and glutathione have been shown to act as sulfane sulfur acceptors in vitro, it is thought that the latter acts as the main acceptor in vivo. The electrons are transferred via FAD and quinones to the electron transfer chain. Unlike the bacterial homolog (EC
1.8.5.4 , bacterial sulfide:quinone reductase), which repeats the catalytic cycle without releasing the product, producing a polysulfide, the eukaryotic enzyme transfers the persulfide to an acceptor at the end of each catalytic cycle.
History
EC 1.8.5.8 created 2017
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K22470 eukaryotic sulfide quinone oxidoreductase
Genes
CIMI : 108298695 108315795(SQOR)
NPO : 129504077(SQOR) 129504320
NVS : 122892228 122893264(SQOR)
ODA : 120852946(SQOR) 120853154
XLA : 379770(sqor.L) 380565(sqor.S)
MUO : 115459317 115459801(SQOR)
SANH : 107662445 107662477 107688928
CAUA : 113043523 113043524 113067036
CGIB : 127947001 128014550
MASI : 127436159 127437418
CHAR : 105892492 105892493(sqor)
TFS : 130535902 130535903(sqor)
CGOB : 115009417 115009485
MSAM : 119894398 119894399
CUD : 121514748(sqor) 121514749
ALAT : 119024049 119024050
AOCE : 111577707 111577712(sqor)
SSEN : 122775508 122775509
MALB : 109954036 109972679 109972685
SJO : 128359325(sqor) 128359326
SASA : 106561757 106584721
STRU : 115192872 115196587
OTW : 112251440(sqor) 112265884
SALP : 111972037 112071120
SNH : 120052334(sqor) 120066765
CCLU : 121531566 121540684
PSPA : 121294822 121304433
ARUT : 117429902 117963045
DSI : Dsimw501_GD13825(Dsim_GD13825)
RZE : 108368788 108373987 108378081
AALB : 109429124 115261402
OTU : 111422828 111423941 111424030 111424058
PMAC : 106708022 106713348
PRAP : 111000149 111000150
LSIN : 126979151 126979152
PTRU : 123507919 123507920
PPOI : 119112283 119112637
RSAN : 119376612 119394827
LPOL : 106465023 106467523
CEL : CELE_F02H6.5(sqrd-1) CELE_Y9C9A.16(Y9C9A.16)
CRQ : GCK72_013043 GCK72_013044
MCAF : 127722031 127722032
MMER : 123524296 128556825
RPHI : 132739261 132739262 132739263 132753824
DPOL : 127875161 127875162
LAK : 106172774 106174519 106174571
ATEN : 116300013 116300014
NTE : NEUTE1DRAFT68211(NEUTE1DRAFT_68211)
TMN : UCRPA7_3713 UCRPA7_4975
PFY : PFICI_06662 PFICI_07567
BFU : BCIN_08g00090 BCIN_12g05950
ANI : ANIA_01825 ANIA_08346
APUU : APUU_10971S APUU_61420A
PNO : SNOG_12870(SNOG_12869)
BZE : COCCADRAFT_30189 COCCADRAFT_85909
BSC : COCSADRAFT_158390 COCSADRAFT_346259
BOR : COCMIDRAFT_37021 COCMIDRAFT_9950
AALT : CC77DRAFT_1099663 CC77DRAFT_951339
NPA : UCRNP2_6363 UCRNP2_7437
CCAC : CcaHIS019_0205440(CcaverHIS019_0205440)
HIR : HETIRDRAFT_32066(sqor)
ABP : AGABI1DRAFT111296(AGABI1DRAFT_111296)
ABV : AGABI2DRAFT190518(AGABI2DRAFT_190518)
SCM : SCHCO_02607641(SCHCODRAFT_02607641)
CPUT : CONPUDRAFT_139667 CONPUDRAFT_79894
SLA : SERLADRAFT_443941 SERLADRAFT_480763
SRE : PTSG_09564 PTSG_09600
PTM : GSPATT00025988001 GSPATT00030239001 GSPATT00033070001
SMIN : v1.2.018790.t1(symbB.v1.2.018790.t1)
EHX : EMIHUDRAFT_224838 EMIHUDRAFT_310574
» show all
Taxonomy
Reference
Authors
Vande Weghe JG, Ow DW
Title
A fission yeast gene for mitochondrial sulfide oxidation.
Journal
Sequence
Reference
Authors
Hildebrandt TM, Grieshaber MK
Title
Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria.
Journal
Reference
Authors
Jackson MR, Melideo SL, Jorns MS
Title
Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite.
Journal
Sequence
Reference
Authors
Libiad M, Yadav PK, Vitvitsky V, Martinov M, Banerjee R
Title
Organization of the human mitochondrial hydrogen sulfide oxidation pathway.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.8.5.8
ExPASy - ENZYME nomenclature database: 1.8.5.8
BRENDA, the Enzyme Database: 1.8.5.8