KEGG   ENZYME: 1.8.98.7
Entry
EC 1.8.98.7                 Enzyme                                 
Name
cysteine-type anaerobic sulfatase-maturating enzyme;
anSME;
Cys-type anaerobic sulfatase-maturating enzyme;
anaerobic sulfatase maturase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With other, known, physiological acceptors
Sysname
[sulfatase]-L-cysteine:S-adenosyl-L-methionine oxidoreductase (3-oxo-L-alanine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + a [sulfatase]-L-cysteine + H2O = a [sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine + hydrogen sulfide
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[sulfatase]-L-cysteine [CPD:C21740];
H2O [CPD:C00001]
Product
[sulfatase]-3-oxo-L-alanine [CPD:C21741];
5'-deoxyadenosine [CPD:C05198];
L-methionine [CPD:C00073];
hydrogen sulfide [CPD:C00283]
Comment
A radical S-adenosylmethionine (AdoMet) enzyme that contains three [4Fe-4S] clusters. The enzyme, found in some bacteria, activates a type I sulfatase enzyme (EC 3.1.6.1) by converting a conserved L-cysteine residue in the active site to a unique 3-oxo-L-alanine residue that is essential for the sulfatase activity. Some enzymes can also act on L-serine, see EC 1.1.98.7, serine-type anaerobic sulfatase-maturating enzyme and EC 1.8.3.7, formylglycine-generating enzyme.
History
EC 1.8.98.7 created 2020
Reference
1  [PMID:16766528]
  Authors
Berteau O, Guillot A, Benjdia A, Rabot S
  Title
A new type of bacterial sulfatase reveals a novel maturation pathway in prokaryotes.
  Journal
J Biol Chem 281:22464-70 (2006)
DOI:10.1074/jbc.M602504200
  Sequence
[cpe:CPE0635]
Reference
2  [PMID:18408004]
  Authors
Benjdia A, Subramanian S, Leprince J, Vaudry H, Johnson MK, Berteau O
  Title
Anaerobic sulfatase-maturating enzymes, first dual substrate radical S-adenosylmethionine enzymes.
  Journal
J Biol Chem 283:17815-26 (2008)
DOI:10.1074/jbc.M710074200
  Sequence
[cpf:CPF_0616]
Reference
3  [PMID:19489556]
  Authors
Benjdia A, Leprince J, Sandstrom C, Vaudry H, Berteau O
  Title
Mechanistic investigations of anaerobic sulfatase-maturating enzyme: direct Cbeta H-atom abstraction catalyzed by a radical AdoMet enzyme.
  Journal
J Am Chem Soc 131:8348-9 (2009)
DOI:10.1021/ja901571p
Reference
4  [PMID:20218986]
  Authors
Benjdia A, Subramanian S, Leprince J, Vaudry H, Johnson MK, Berteau O
  Title
Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes?
  Journal
FEBS J 277:1906-20 (2010)
DOI:10.1111/j.1742-4658.2010.07613.x
Reference
5  [PMID:23477283]
  Authors
Grove TL, Ahlum JH, Qin RM, Lanz ND, Radle MI, Krebs C, Booker SJ
  Title
Further characterization of Cys-type and Ser-type anaerobic sulfatase maturating  enzymes suggests a commonality in the mechanism of catalysis.
  Journal
Biochemistry 52:2874-87 (2013)
DOI:10.1021/bi400136u
  Sequence
[cpe:CPE0635]
Other DBs
ExplorEnz - The Enzyme Database: 1.8.98.7
IUBMB Enzyme Nomenclature: 1.8.98.7
ExPASy - ENZYME nomenclature database: 1.8.98.7
BRENDA, the Enzyme Database: 1.8.98.7

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