KEGG   ENZYME: 2.1.1.116
Entry
EC 2.1.1.116                Enzyme                                 
Name
3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline [RN:R03832]
Reaction(KEGG)
R03832;
(other) R05212
Substrate
S-adenosyl-L-methionine [CPD:C00019];
3'-hydroxy-N-methyl-(S)-coclaurine [CPD:C05202]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-reticuline [CPD:C02105]
Comment
Involved in isoquinoline alkaloid metabolism in plants. The enzyme has also been shown to catalyse the methylation of (RS)-laudanosoline, (S)-3'-hydroxycoclaurine and (RS)-7-O-methylnorlaudanosoline.
History
EC 2.1.1.116 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13386  3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
Genes
MING122065299 122065307
PSOM113294323 113326743 113326977 113327792 113328438 113339850 113339870 113353561
MSIN131239723
Reference
1
  Authors
Frenzel, T., Zenk, M.H.
  Title
S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway.
  Journal
Phytochemistry 29:3505-3511 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.116
IUBMB Enzyme Nomenclature: 2.1.1.116
ExPASy - ENZYME nomenclature database: 2.1.1.116
BRENDA, the Enzyme Database: 2.1.1.116
CAS: 132084-81-2

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