KEGG   ENZYME: 2.1.1.117
Entry
EC 2.1.1.117                Enzyme                                 
Name
(S)-scoulerine 9-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-scoulerine = S-adenosyl-L-homocysteine + (S)-tetrahydrocolumbamine [RN:R03835]
Reaction(KEGG)
R03835
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-scoulerine [CPD:C02106]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-tetrahydrocolumbamine [CPD:C04118]
Comment
The product of this reaction is a precursor for protoberberine alkaloids in plants
History
EC 2.1.1.117 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13397  (S)-scoulerine 9-O-methyltransferase
Genes
FVE101292538 101314449
RCN112164599 112175727 112178128
PPER18780355
PMUM103325170
PAVI110774000
PDUL117626380
MDM103435029
PXB103951323 103951351 103951352 103966079 103966114
JRE108979314 108981078 108981935 108986025 109004694 109018241 109018878 118348298
CILL122278514 122278733 122278857 122278863
QSU111993653 111993655 112036190
QLO115961636
TWL120012623
VVI100265214
VRI117924373
NNU104586605 104600131
PSOM113293137 113322507 113362144
MSIN131239482 131242245 131242246 131242247 131242248 131252155 131252157
 » show all
Reference
1  [PMID:24253642]
  Authors
Muemmler S, Rueffer M, Nagakura N, Zenk MH
  Title
S-adenosyl-L-methionine: (S)-scoulerine 9-O-methyltransferase, a highly stereo- and regio-specific enzyme in tetrahydroprotoberberine biosynthesis.
  Journal
Plant Cell Rep 4:36-9 (1985)
DOI:10.1007/BF00285501
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.117
IUBMB Enzyme Nomenclature: 2.1.1.117
ExPASy - ENZYME nomenclature database: 2.1.1.117
BRENDA, the Enzyme Database: 2.1.1.117
CAS: 96380-65-3

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