KEGG ENZYME: 2.1.1.118

ENZYME: 2.1.1.118

Entry

EC 2.1.1.118                Enzyme

Name

columbamine O-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:columbamine O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + palmatine [RN:R03721]

Reaction(KEGG)

R03721

Substrate

S-adenosyl-L-methionine [CPD:C00019];
columbamine [CPD:C01795]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
palmatine [CPD:C05315]

Comment

The product of this reaction is a protoberberine alkaloid that is widely distributed in the plant kingdom. This enzyme is distinct in specificity from EC 2.1.1.88, 8-hydroxyquercetin 8-O-methyltransferase.

History

EC 2.1.1.118 created 1999

Pathway

ec00950

Isoquinoline alkaloid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K13398

columbamine O-methyltransferase

Reference

Authors

Rueffer, M., Amann, M., Zenk, M.H.

Title

S-Adenosyl-L-methionine:columbamine O-methyltransferase, a compartmentalized enzyme in protoberberine biosynthesis.

Journal

Plant Cell Reports 3:182-185 (1986)

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.118

IUBMB Enzyme Nomenclature:

2.1.1.118

ExPASy - ENZYME nomenclature database:

2.1.1.118

BRENDA, the Enzyme Database:

2.1.1.118

CAS:	105843-76-3

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