KEGG   ENZYME: 2.1.1.142
Entry
EC 2.1.1.142                Enzyme                                 
Name
cycloartenol 24-C-methyltransferase;
sterol C-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cycloartenol = S-adenosyl-L-homocysteine + cyclolaudenol [RN:R12458]
Reaction(KEGG)
R12458
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cycloartenol [CPD:C01902]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
cyclolaudenol [CPD:C22175]
Comment
S-Adenosyl-L-methionine methylates the Si face of the 24(25)-double bond with elimination of a hydrogen atom from the pro-Z methyl group at C-25.
History
EC 2.1.1.142 created 2001, modified 2019
Reference
1  [PMID:10882005]
  Authors
Mangla AT, Nes WD.
  Title
Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition.
  Journal
Bioorg Med Chem 8:925-36 (2000)
DOI:10.1016/S0968-0896(00)00040-7
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.142
IUBMB Enzyme Nomenclature: 2.1.1.142
ExPASy - ENZYME nomenclature database: 2.1.1.142
BRENDA, the Enzyme Database: 2.1.1.142
CAS: 50936-46-4

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
All databases (6)   

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