Entry
Name
16S rRNA (guanine966-N2)-methyltransferase;
yhhF (gene name);
rsmD (gene name);
m2G966 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:16S rRNA (guanine966-N2)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanine966 in 16S rRNA = S-adenosyl-L-homocysteine + N2-methylguanine966 in 16S rRNA [RN:
R07234 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
guanine966 in 16S rRNA
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
N2-methylguanine966 in 16S rRNA
Comment
The enzyme efficiently methylates guanine966 of the assembled 30S subunits in vitro. Protein-free 16S rRNA is not a substrate for RsmD [1]. The enzyme specifically methylates guanine966 at N2 in 16S rRNA.
History
EC 2.1.1.171 created 1976 as EC 2.1.1.52, part transferred 2010 to EC 2.1.1.171
Orthology
K08316 16S rRNA (guanine966-N2)-methyltransferase
Genes
ECOO : ECRM13514_4419(rsmD)
ECOH : ECRM13516_4217(rsmD)
ELR : ECO55CA74_19920(rsmD)
ECOA : APECO78_21115(rsmD)
EDJ : ECDH1ME8569_3342(rsmD)
ECOI : ECOPMV1_03785(rsmD)
SEM : STMDT12_C36260(rsmD)
SETC : CFSAN001921_22590(rsmD)
SEEN : SE451236_03055(rsmD)
SENH : CFSAN002069_14330(rsmD)
SEEH : SEEH1578_03930(rsmD)
SENJ : CFSAN001992_15780(rsmD)
SEEC : CFSAN002050_24810(rsmD)
SEEB : SEEB0189_002020(rsmD)
SENC : SEET0819_01445(rsmD)
REE : electrica_00272(rsmD)
RTG : NCTC13098_00369(rsmD)
SENM : TRABTM_A_01220(rsmD)
CLAP : NCTC11466_00103(rsmD)
KIE : NCTC12125_04176(rsmD)
CMIK : PMARG_ME00255(rsmD)
AHN : NCTC12129_00315(rsmD)
METY : MRY16398_03370(rsmD)
PTF : PROFFT_A_06370(rsmD)
PSHI : SAMEA2665130_0165(rsmD)
SMW : SMWW4_v1c02210(rsmD)
SERS : SERRSCBI_00960(rsmD)
SFJ : SAMEA4384070_0192(rsmD)
SOF : NCTC11214_02001(rsmD)
SERA : Ser39006_003270(rsmD)
PAQU : DMB82_0000445(rsmD)
DIC : Dpoa569_000107(rsmD)
EHD : ERCIPSTX3056_135(rsmD)
BAPF : BUMPF009_CDS00563(yhhf)
BAPG : BUMPG002_CDS00564(yhhf)
BAPU : BUMPUSDA_CDS00562(yhhf)
BAPW : BUMPW106_CDS00563(yhhf)
PVA : Pvag_3012(yhhf1) Pvag_3013(yhhf3)
TPTY : NCTC11468_00035(rsmD)
PHEI : NCTC12003_03293(rsmD)
PRJ : NCTC6933_03398(rsmD)
LRI : NCTC12151_00222(rsmD)
HIC : NTHIC486_00212(rsmD)
HPIT : NCTC13334_00805(rsmD)
HHZ : NCTC10839_00328(rsmD)
HAEG : NCTC8502_00233(rsmD)
PDAG : 4362423_01839(rsmD)
ADP : NCTC12871_01611(rsmD)
ALIG : NCTC10568_01670(rsmD)
ASEG : NCTC10977_00221(rsmD)
AVT : NCTC3438_00620(rsmD)
RPNE : NCTC8284_00648(rsmD)
PAET : NCTC13378_00252(rsmD)
XPH : XppCFBP6546_00445(rsmD)
XHD : LMG31886_17610(rsmD)
LLZ : LYB30171_00926(rsmD)
VAU : VANGNB10_cI0100c(rsmD)
VPL : SA104470976_02593(rsmD)
PAEB : NCGM1900_0375(yhhF)
PVD : CFBP1590__4900(rsmD)
PPRC : PFLCHA0_c58140(rsmD)
PMUD : NCTC8068_05081(rsmD)
PFW : PF1751_v1c52020(rsmD)
PFF : PFLUOLIPICF709960(rsmD)
PPUU : PputUW4_05138(rsmD)
PTRT : HU722_0027915(rsmD)
PTAE : NCTC10697_00276(rsmD)
MCAT : MC25239_01204(rsmD)
MCUN : NCTC10297_01656(rsmD)
SCAA : TUM17387_36900(rsmD)
SALH : HMF8227_00352(rsmD)
LLG : 44548918_02264(yhhF)
LJR : NCTC11533_02353(yhhF)
LCJ : NCTC11976_00241(yhhF)
LWA : SAMEA4504053_3178(rsmD)
LSS : NCTC12082_01474(rsmD)
LADL : NCTC12735_01517(yhhF)
THIO : AYJ59_02505(rsmD) AYJ59_03475(rsmD)
TZO : THMIRHAT_02630(rsmD)
RHEI : ATY27_06900 ATY27_17960
TFRI : Thiofri_00420(rsmD)
TNI : TVNIR_0211(rsmD_[H])
GAI : IMCC3135_05265(rsmD)
ALCA : ASALC70_02128(rsmD)
AEL : NCTC12917_00292(rsmD)
CHJ : NCTC10426_00923(rsmD)
CDIZ : CEDIAZO_03509(rsmD)
NWE : SAMEA3174300_1907(rsmD)
NZO : SAMEA4504057_0044(rsmD)
NCI : NCTC10296_00177(rsmD)
NCZ : NCTC10294_01640(rsmD)
NANI : NCTC12227_01890(rsmD)
ECOR : SAMEA4412678_1128(rsmD)
REH : H16_A0366(h16_A0366)
PLG : NCTC10937_00348(rsmD)
LMIR : NCTC12852_00253(rsmD)
BTRM : SAMEA390648701854(rsmD)
AXX : ERS451415_05337(rsmD)
LIM : L103DPR2_02513(rsmD)
LIH : L63ED372_02412(rsmD)
URU : DSM104443_00367(rsmD)
UPL : DSM104440_00416(rsmD)
RBS : RHODOSMS8_00167(rsmD)
SFD : USDA257_c05170(rsmD)
SAME : SAMCFNEI73_Ch0840(rsmD)
ALF : CFBP5473_12345(rsmD)
ASAL : CFBP5507_01645(rsmD)
RPUS : CFBP5875_01980(rsmD)
ALEG : CFBP4996_01775(rsmD)
RGA : RGR602_CH00895(rsmD)
RPHA : AMC79_CH00861(rsmD)
RLW : RlegWSM1455_02455(rsmD)
RBW : RLCC275e_02515(rsmD)
NEN : NCHU2750_03970(rsmD)
BSW : IY71_10115 IY71_12095
BSG : IY72_09850 IY72_11630
BRK : CWS35_00110(rsmD) CWS35_37175(rsmD)
BSEP : HAP48_0022210(rsmD)
BCAN : BcanWSM471_32935(rsmD)
VGO : GJW-30_1_01571(rsmD)
BHS : BM1374165_00269(rsmD)
BTX : BM1374166_00260(rsmD)
BEZ : NCTC12898_00151(rsmD)
MMES : MMSR116_07590(rsmD)
MTUN : MTUNDRAET4_3967(rsmD)
FIL : BN1229_v1_0151(yhhF)
FIY : BN1229_v1_0155(yhhF)
BVY : NCTC9239_01401(rsmD)
TSV : DSM104635_01275(rsmD)
PHP : PhaeoP97_00579(rsmD)
PPIC : PhaeoP14_02698(rsmD)
SINL : DSM14862_00346(rsmD)
SPSE : SULPSESMR1_03447(rsmD)
RMM : ROSMUCSMR3_02976(rsmD)
AHT : ANTHELSMS3_00152(rsmD)
LALG : LentiSH36_00225(rsmD)
LVS : LOKVESSMR4R_02939(rsmD)
AALK : LGT41_0005830(rsmD)
SFLA : SPHFLASMR4Y_01211(rsmD)
SBF : JCM31447_05220(rsmD)
BAZ : BAMTA208_09645(ylbH)
BSON : S101395_03234(rsmD)
BFD : NCTC4823_02598(rsmD)
BLEN : NCTC4824_02776(ylbH)
SDP : NCTC12225_01906(rsmD)
SPIC : SAMEA4384060_1815(rsmD)
SSH : NCTC13712_01068(rsmD)
SSIM : SAMEA4384339_1035(rsmD)
SSTE : SAMEA4384403_1694(rsmD)
LGZ : NCTC10812_00794(rsmD)
GMO : NCTC11323_00536(rsmD)
GHA : NCTC10459_01216(rsmD)
BAYD : BSPP4475_07550(rsmD)
PNK : AASFL403_10425(rsmD)
SVB : NCTC12167_01600(rsmD)
SMEN : SAMEA4412692_1565(rsmD)
SFER : NCTC12278_00482(rsmD)
SCAI : NCTC12191_01210(rsmD)
SPSU : NCTC13786_00730(rsmD)
SPOC : NCTC10925_00510(rsmD)
SAUP : NCTC3168_00210(rsmD)
SURN : NCTC13766_00518(rsmD)
SVF : NCTC3166_00563(rsmD)
SMIE : NCTC11169_00394(rsmD)
ECEC : NCTC12421_01158(rsmD)
AMIT : DBT49_0002635(rsmD)
CCOH : SAMEA4530647_1047(rsmD)
BPRO : PMF13cell1_04150(rsmD)
BLUI : Blut17040_13450(rsmD)
CSCI : HDCHBGLK_03086(rsmD)
CBAR : PATL70BA_0039(rsmD)
AMIC : Ami3637_16815(rsmD)
ABUT : Ami103574_08535(rsmD)
PHX : KGNDJEFE_00905(rsmD)
PHAR : NCTC13077_00585(rsmD)
PIV : NCTC13079_00782(rsmD)
VRM : 44547418_00850(rsmD)
VDN : NCTC11831_01111(rsmD)
MANA : MAMMFC1_03952(rsmD)
PFAC : PFJ30894_01256(rsmD)
MCAP : MCCPF38_00260(rsmD)
MCAR : MCCPILRI181_00257(rsmD)
PPHY : H7686_0001535(rsmD)
AHK : NCTC10172_00375(MCYN0472)
AAXA : NCTC10138_01252(rsmD)
MTAB : MTABA_v1c02040(rsmD)
MCOL : MCOLE_v1c02120(rsmD)
EML : EMELA_v1c03290(rsmD)
EFR : EFREU_v1c02430(rsmD)
ELJ : ELUMI_v1c03480(rsmD)
ESX : ESOMN_v1c02100(rsmD)
SLL : SLITO_v1c01760(rsmD)
SCJ : SCANT_v1c08450(rsmD)
SHJ : SHELI_v1c07830(rsmD)
SCOU : SCORR_v1c01720(rsmD)
SPRN : S100390_v1c03010(rsmD)
SPIT : STU14_v1c03010(rsmD)
STAB : STABA_v1c08870(rsmD)
SGQ : SGLAD_v1c08260(rsmD)
SPLT : SPLAT_v1c03520(rsmD)
MNU : NCTC10166_00504(rsmD)
MOE : NCTC10151_00654(rsmD)
MGLY : NCTC10194_00594(MCYN0472)
MCOU : NCTC10179_00445(MCYN0472)
MCOM : NCTC10178_00075(rsmD)
MPU : MYPU_6880(MYPU_6880)
MEDW : NCTC10132_00759(MCYN0472)
MGAL : NCTC10186_00253(MCYN0472)
MCIT : NCTC10181_00520(MCYN0472)
MMAU : NCTC10168_00593(rsmD)
MMEL : NCTC10153_00352(rsmD)
MCOB : NCTC10184_00561(rsmD)
MALA : NCTC10135_00971(rsmD)
MSAI : NCTC10113_01388(rsmD_2)
PCAT : Pcatena_10130(rsmD)
MBAI : MB901379_01562(rsmD)
MPHL : MPHLCCUG_02085(rsmD)
MTHN : 4412656_01581(rsmD)
MAUU : NCTC10437_02012(rsmD)
MFLV : NCTC10271_03379(rsmD)
MSAL : DSM43276_03059(rsmD)
MTER : 4434518_02615(rsmD)
CDIP : ERS451417_01053(rsmD)
COI : CPCIP5297_04795(rsmD)
CUN : Cul210932_1024(rsmD)
CUQ : Cul210931_0982(rsmD)
CUJ : CUL131002_1006(rsmD)
CMIN : NCTC10288_01359(rsmD)
CRL : NCTC7448_01808(rsmD)
CCYS : SAMEA4530656_1232(rsmD)
NFR : ERS450000_05725(rsmD)
NAD : NCTC11293_05407(rsmD)
RCR : NCTC10994_01016(rsmD)
RANT : RHODO2019_04370(rsmD)
SLE : sle_20860(sle_20860)
SGOB : test1122_20220(rsmD)
SXT : KPP03845_105311(rsmD)
AMAU : DSM26151_18110(rsmD)
PSEV : USB125703_01192(rsmD)
AAGI : NCTC2676_1_01702(rsmD)
PSNI : NIBR502771_13125(rsmD)
MICK : B1A86_00004350(rsmD)
DCO : SAMEA4475696_1050(rsmD)
CGRN : 4412665_01567(rsmD)
PAUS : NCTC13651_02282(rsmD)
RAIN : Rai3103_16300(rsmD)
BROO : brsh051_04050(rsmD)
NAQU : ENKNEFLB_01358(rsmD)
AGRA : AGRA3207_006266(rsmD)
TBW : NCTC13354_01764(rsmD)
ATIM : CYJ17_0006205(rsmD)
AHW : NCTC11636_00103(rsmD)
AIR : NCTC12972_01112(rsmD)
ASLA : NCTC11923_01564(rsmD)
AVC : NCTC10951_00404(rsmD)
AREP : ID810_07825(rsmD) ID810_07900(rsmD)
ABAM : B1s21122_04085(rsmD)
BALA : DSM104299_02436(rsmD)
SBAE : DSM104329_02227(rsmD)
SYY : SYNGTS_2139(slr0383)
SYT : SYNGTI_2138(slr0383)
SYS : SYNPCCN_2137(slr0383)
SYQ : SYNPCCP_2137(slr0383)
LET : O77CONTIG1_03314(rsmD)
CSUI : Chls_832(methyltransferase)
OBG : Verru16b_00834(rsmD)
LCRE : Pla8534_13440(rsmD)
SACI : Sinac_5937 Sinac_7320 Sinac_7330
AGV : OJF2_13870(rsmD_1) OJF2_17810(rsmD_2)
BCOI : bcCo53_000200(rsmD)
BPUR : bpuSUM_000202(rsmD)
BVW : bvRMA01_000200(rsmD)
FPOL : ERS445057_00860(rsmD)
GGR : HKW67_04910(rsmD) HKW67_18875
BTHO : Btheta7330_04278(rsmD)
BCEL : BcellWH2_03890(rsmD)
PCRE : NCTC12858_01530(rsmD)
PCAG : NCTC12856_01616(rsmD)
POC : NCTC13071_00173(rsmD)
SMIZ : 4412673_02194(rsmD)
SDJ : NCTC13534_03160(rsmD)
STHA : NCTC11429_04480(rsmD)
PHG : KCTC32516_02169(rsmD)
AALG : AREALGSMS7_02855(rsmD)
KOS : KORDIASMS9_02619(rsmD)
KAN : IMCC3317_44350(rsmD)
SPON : HME9304_02704(rsmD)
CGLE : NCTC11432_04043(rsmD)
CTAI : NCTC12078_01511(rsmD)
CTAK : 4412677_01206(rsmD)
CHRJ : CHRYMOREF3P_3613(rsmD)
CJG : NCTC13459_02643(rsmD)
CANT : NCTC13489_01599(rsmD)
» show all
Taxonomy
Reference
Authors
Lesnyak DV, Osipiuk J, Skarina T, Sergiev PV, Bogdanov AA, Edwards A, Savchenko A, Joachimiak A, Dontsova OA
Title
Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.171