Entry
Name
malonyl-[acyl-carrier protein] O-methyltransferase;
BioC
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:malonyl-[acyl-carrier protein] O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + malonyl-[acyl-carrier protein] = S-adenosyl-L-homocysteine + malonyl-[acyl-carrier protein] methyl ester [RN:
R09543 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
malonyl-[acyl-carrier protein] [CPD:
C01209 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
malonyl-[acyl-carrier protein] methyl ester [CPD:
C19673 ]
Comment
Involved in an early step of biotin biosynthesis in Gram-negative bacteria. This enzyme catalyses the transfer of a methyl group to the omega-carboxyl group of malonyl-[acyl-carrier protein] forming a methyl ester. The methyl ester is recognized by the fatty acid synthetic enzymes, which process it via the fatty acid elongation cycle to give pimelyl-[acyl-carrier-protein] methyl ester [5]. While the enzyme can also accept malonyl-CoA, it has a much higher activity with malonyl-[acyl-carrier protein] [6]
History
EC 2.1.1.197 created 2010, modified 2013
Pathway
Orthology
K02169 malonyl-CoA O-methyltransferase
Genes
ECOO : ECRM13514_0852(bioC)
ECOH : ECRM13516_0807(bioC)
ECW : EcE24377A_0840(bioC)
EDJ : ECDH1ME8569_0730(bioC)
ECOI : ECOPMV1_00780(bioC)
REE : electrica_03542(bioC)
RTG : NCTC13098_05232(bioC_2)
RIG : AOQ88_02120 AOQ88_02330
CLAP : NCTC11466_03200(bioC_3)
KIE : NCTC12125_02211(bioC_2)
AHN : NCTC12129_03432(bioC_2)
METY : MRY16398_39940(bioC)
PSHI : SAMEA2665130_1580(bioC)
YPG : YpAngola_A1427(bioC)
YPI : YpsIP31758_2842(bioC)
SMW : SMWW4_v1c12820(bioC)
SFJ : SAMEA4384070_1368(bioC_1)
SOF : NCTC11214_05591(bioC_3)
SERA : Ser39006_011260(bioC)
PAQU : DMB82_0012710(bioC)
DIC : Dpoa569_002267(bioC)
TPTY : NCTC11468_01257(bioC_2)
PHEI : NCTC12003_02897(bioC)
PRJ : NCTC6933_01147(bioC)
ANS : ArsFIN_15590(bioC_1)
HHZ : NCTC10839_01314(bioC_2)
PDAG : 4362423_00061(bioC_1)
APA : APP7_0997(bioC) APP7_1890(bioC)
ASI : ASU2_01935 ASU2_08345
ASS : ASU1_01945 ASU1_08415
AAP : NT05HA_1511 NT05HA_1515
ASEG : NCTC10977_00804(bioC_2)
AVT : NCTC3438_02125(bioC)
RPNE : NCTC8284_01959(bioC_1)
PAET : NCTC13378_00227(bioC_2)
XCC : XCC0383(bioC) XCC1678(bioC)
XCA : xcc-b100_0410(bioC) xcc-b100_2581
XCP : XCR_1914 XCR_4131(bioC)
XCV : XCV0398(bioC) XCV1731
XAX : XACM_0372(bioC) XACM_1718
XAC : XAC0383(bioC) XAC1698(bioC)
XCI : XCAW_00790(smtA) XCAW_02374(smtA)
XCT : J151_00505 J151_01852
XCJ : J158_00502 J158_01840
XCU : J159_00502 J159_01840
XCN : J169_00501 J169_01849
XCW : J162_00501 J162_01840
XCR : J163_00501 J163_01840
XCM : J164_00501 J164_01840
XCF : J172_00496 J172_01843
XFU : XFF4834R_chr03690(bioC) XFF4834R_chr28130
XAO : XAC29_01975 XAC29_08550
XOM : XOO0213(XOO0213) XOO2838(XOO2838)
XOO : XOO0233(bioC) XOO2987(bioC)
XOP : PXO_00196 PXO_03630(bioC)
XOY : AZ54_01125 AZ54_09055
XOR : XOC_2818 XOC_4517(bioC)
XOZ : BE73_00935 BE73_13650
XSA : SB85_02240 SB85_14750
XTN : FD63_01710 FD63_09970
XVE : BJD12_14650 BJD12_21925
XPE : BJD13_08120 BJD13_15020
XHR : XJ27_01890 XJ27_17735
XGA : BI317_14615 BI317_21955
XPH : XppCFBP6546_09900(bioC) XppCFBP6546_18770(XppCFBP6546P_18770)
XVA : C7V42_01895(bioC) C7V42_09110
XAN : AC801_01805 AC801_08580
XAR : XB05_03545 XB05_18545
XHY : FZ025_11160(bioC) FZ025_19670
XCZ : EBN15_01905(bioC) EBN15_07260
XEU : XSP_000394(bioC) XSP_001798
XHD : LMG31886_04320(bioC) LMG31886_26120(COQ5_1)
XPR : MUG10_00490 MUG10_08350(bioC)
XAG : HEP73_00442 HEP73_02238
XDY : NYR95_02195(bioC) NYR95_09940
XAS : HEP74_00431 HEP74_02075
LLZ : LYB30171_00098(bioC)
LUS : E5843_00095(bioC) E5843_02715(bioD)
FED : LQ772_14825 LQ772_16240(bioC)
RHD : R2APBS1_0669 R2APBS1_3672
RTH : LRK53_00510 LRK53_03020(bioC)
DJI : CH75_13015 CH75_21005
DJA : HY57_02675 HY57_06630
DCS : ISN74_00715(bioC) ISN74_09935
DTL : H8F01_10775(bioC) H8F01_19980
DTA : DYST_00651 DYST_02934
LRZ : BJI69_03875 BJI69_08670
LPY : FIV34_03475 FIV34_19575(bioC)
LANH : KR767_05665(bioC) KR767_17310
LFL : IM816_01070(bioC) IM816_15415
LAEG : L2Y94_17845 L2Y94_19920(bioC)
LAEO : L2Y97_03490 L2Y97_20905(bioC)
LAES : L2Y96_03990 L2Y96_21450(bioC)
VAU : VANGNB10_cI1727c(bioC)
VPL : SA104470976_00862(bioC)
PAEB : NCGM1900_0514(bioC)
PCQ : PcP3B5_06330(bioC_1)
PPRC : PFLCHA0_c56410(bioC)
PMUD : NCTC8068_04913(bioC)
PFW : PF1751_v1c50390(bioC)
PPUU : PputUW4_04980(bioC)
PTRT : HU722_0027080(bioC)
PTW : TUM18999_06830(bioC)
PTAE : NCTC10697_00425(bioC)
MSHE : MAALD49_27310(bioC)
MCAT : MC25239_00191(bioC)
MCUN : NCTC10297_00345(bioC)
SCAA : TUM17387_15710(bioC)
SALH : HMF8227_01335(bioC)
CBU : CBU_0467(bioC.1) CBU_1004(bioC.2)
CBS : COXBURSA331_A0573 COXBURSA331_A0936
CBD : CBUD_1043(bioC.1) CBUD_1611(bioC.2)
CBG : CbuG_1003(bioC) CbuG_1546
CBC : CbuK_0838(bioC.1) CbuK_1393(bioC.2)
CEY : CleRT_09920(bioC) CleRT_12120
CEA : Z664_02045(bioC.1) Z664_02670(bioC.2)
CEND : EGQ50_01990 EGQ50_02570
CENO : CEAn_00401 CEAn_00470
ALG : AQULUS_03890(bioC_1) AQULUS_18770(bioC_2)
ASIP : AQUSIP_03870(bioC_1) AQUSIP_21240(bioC_2)
CEQ : B1F76_02025 B1F76_02655
LES : CCU22_01170 CCU22_01385
LLG : 44548918_02010(bioC)
LJR : NCTC11533_00748(bioC)
LCJ : NCTC11976_01308(bioC)
LWA : SAMEA4504053_2568(bioC)
LSS : NCTC12082_01183(bioC_2)
LADL : NCTC12735_00394(bioC)
LANT : TUM19329_29110(bioC)
MISZ : MishRS11D_04710(bioC)
FTI : FTS_0401 FTS_1246(bioC)
FTO : X557_02180 X557_06615
FTM : FTM_0514 FTM_0853(bioC)
FTN : FTN_0450 FTN_0813(bioC)
FCF : FNFX1_0443 FNFX1_0822
FCN : FN3523_0414 FN3523_0972
FHI : FSC454_02090 FSC454_05200
FRT : F7308_0465 F7308_1315
FPER : ACH24_03340 ACH24_04550
FHA : CDV26_07690 CDV26_09530
FRX : F7310_02400 F7310_05005
FRM : BBG19_0837 BBG19_1344
FAD : CDH04_01750 CDH04_09695
FMI : F0R74_00645 F0R74_03555
FOO : CGC45_04250 CGC45_06775
FNN : FSC774_02590 FSC774_06920
FSR : KQR59_02190 KQR59_05125
FRL : FIP56_02295 FIP56_05175
FGU : SD28_04655 SD28_07595
AFRI : E3E15_04465 E3E15_06165
AII : E4K63_01650 E4K63_04760
MMAF : GCM100_21900(bioC1)
TIB : THMIRHAM_01770(bioC)
TSE : THMIRHAS_01700(bioC1)
TZO : THMIRHAT_01980(bioC)
TFRI : Thiofri_03795(bioC)
TWG : Thiowin_01221(bioC_2)
TNI : TVNIR_0192(bioC_[H])
SHAI : LMH63_01545 LMH63_11685(bioC)
GAI : IMCC3135_05165(bioC)
THIC : TspCOW1_26770(bioC)
ALCA : ASALC70_01669(bioC)
AEL : NCTC12917_01351(bioC_2)
WCN : PE074_02775 PE074_07970(bioC)
CDIZ : CEDIAZO_03517(bioC)
NMH : NMBH4476_0265 NMBH4476_0467
NMD : NMBG2136_0271 NMBG2136_1626
NMM : NMBM01240149_1616 NMBM01240149_1816
NMS : NMBM01240355_0275 NMBM01240355_0482
NMQ : NMBM04240196_0277 NMBM04240196_0481(bioC)
NMZ : NMBNZ0533_0272 NMBNZ0533_1777(bioC)
NMW : NMAA_1466(bioC) NMAA_1708
NMX : NMA510612_2262(bioC) NMA510612_2521
NMN : NMCC_1668(bioC) NMCC_1874
NMT : NMV_0296 NMV_0521(bioC)
NMI : NMO_1568(bioC) NMO_1766
NEL : NELON_00775 NELON_05790
NWE : SAMEA3174300_0593(bioC) SAMEA3174300_1729
NFV : FAH67_07740(bioC) FAH67_09595
NZL : D0T92_06765(bioC) D0T92_10245
NBL : GJV52_03435(bioC) GJV52_05215
NZO : SAMEA4504057_0008 SAMEA4504057_1149(bioC)
NCI : NCTC10296_00080(bioC) NCTC10296_00727
NANI : NCTC12227_00976(bioC) NCTC12227_02021
NWD : H3L96_03235 H3L96_06015(bioC)
NSG : H3L94_00655 H3L94_01350
NDN : H3L92_05275(bioC) H3L92_12075
NDU : LVJ88_01235 LVJ88_06995(bioC)
NAW : LVJ86_05930(bioC) LVJ86_10430
VMS : LVJ82_08340 LVJ82_10770(bioC)
NBA : CUN60_01775 CUN60_11930
PTES : JQU52_02410 JQU52_11475(bioC)
USU : LVJ78_00620 LVJ78_07470(bioC)
UTE : LVJ83_01035 LVJ83_08635(bioC)
CHAE : CH06BL_02110(bioC1)
REH : H16_A0340(h16_A0340)
BUE : BRPE67_ACDS01990(bioC)
PLG : NCTC10937_00564(bioC)
LMIR : NCTC12852_00270(bioC)
BUO : BRPE64_ACDS02040(bioC)
LIMN : HKT17_02660 HKT17_14420
LTO : RGQ30_01890 RGQ30_26460
VTR : MYVALT_G_00990(bioC)
BPER : BN118_2023 BN118_3470
BPET : B1917_1943 B1917_3457
BPEU : Q425_28880 Q425_35530
BPAR : BN117_0285 BN117_3087
BBH : BN112_1138 BN112_3127
BBM : BN115_0275 BN115_1816
BBX : BBS798_0285 BBS798_3167
BAV : BAV0235 BAV2451(bioCD)
BHZ : ACR54_00289(bioC_1) ACR54_01409(bioC_2)
BTRM : SAMEA390648701472(tam_2) SAMEA390648704142(bioCD)
BOJ : CBF45_00130 CBF45_01010
AXY : AXYL_04369(bioD) AXYL_06078
AXO : NH44784_025741 NH44784_063511
AXN : AX27061_4591 AX27061_5713
AXX : ERS451415_04622(bioC_1) ERS451415_05848(bioC_2)
ADT : APT56_21100 APT56_26430
AIS : BUW96_11020 BUW96_23745
ASW : CVS48_07970 CVS48_23195(bioD)
ACHR : C2U31_02725 C2U31_16290(bioD)
ADY : HLG70_02325(bioD) HLG70_23465
AMUI : PE062_13915(bioD) PE062_21955
APES : FOC84_14770 FOC84_24035(bioD)
AAEG : RA224_11255(bioD) RA224_30275
TEQ : TEQUI_0707 TEQUI_0893
CDN : BN940_03286 BN940_13306
BPSI : IX83_01035 IX83_01380
PHN : PAEH1_00720 PAEH1_07165
PIG : EGT29_11460(bioD) EGT29_24995
KGY : EHF36_00265(bioD) EHF36_01195
IDC : LRM40_09475(bioC) LRM40_13720
JAJ : EKL02_03710 EKL02_17040
OFO : BRW83_0013(bioC_1) BRW83_1197(bioC_2)
OVB : NB640_00890(bioC) NB640_08170
METR : BSY238_1472 BSY238_2346
DOE : DENOEST_0448(bioC) DENOEST_2250(bioC)
NPV : OHM77_05225 OHM77_10995
NARC : NTG6680_0495 NTG6680_0753(bioC)
SDR : SCD_n02663 SCD_n02980
SNIV : SFSGTM_27570(bioC1)
URU : DSM104443_00709(bioC)
UPL : DSM104440_00665(bioC)
ARES : IWH25_07115(bioC) IWH25_10505(bioC)
AIQ : Azoinq_01665(bioC) Azoinq_04680
OTR : OTERR_05220(bioC) OTERR_17150(bioC)
NIV : JY500_13080 JY500_15850
EBA : ebA1067(bioC) ebA6013(bioC)
ABRE : pbN1_09780(bioC1) pbN1_36090(bioC2)
APET : ToN1_01110(bioC1) ToN1_35250(bioC2)
RBH : B4966_03810 B4966_06875
DEY : HYN24_02670 HYN24_09850(bioC)
DDEN : KI615_13740(bioC) KI615_18105
DECH : GBK02_05095 GBK02_07735(bioC)
QAU : KI612_07430(bioC) KI612_17070
FLE : KI610_15295(bioC) KI610_16650
AZO : azo1891(bioC1) azo2818(bioC2)
AZA : AZKH_0993(bioC) AZKH_2396(bioC) AZKH_2512(bioC)
AZI : AzCIB_0868 AzCIB_2207
AZD : CDA09_05240 CDA09_07140(bioC)
AZR : CJ010_12420 CJ010_17680
THK : CCZ27_11355 CCZ27_13745
TAK : Tharo_2040 Tharo_2398
AZQ : G3580_10390(bioC) G3580_13190
ACOM : CEW83_04695(bioC) CEW83_20700
ZPA : C3497_03560 C3497_06460(bioC)
FPHO : SHINM1_001540(bioC_1) SHINM1_004020(bioC_2)
APP : CAP2UW1_0274 CAP2UW1_2158
ERU : Erum0220(possible_bioC)
PHP : PhaeoP97_00882(bioC)
PPIC : PhaeoP14_00837(bioC)
EBLA : JGUZn3_14800(bioD_2)
ABS : AZOBR_p440137(bioCD)
HTL : HPTL_1307(bioC) HPTL_1657
HPO : HMPREF4655_21446(bioC)
HPX : HMPREF0462_1270(bioC)
HSH : NHP194022_09400(bioC)
CJV : MTVDSCj20_0277(bioC)
CFV : CFVI03293_0084(bioC)
CAMP : CFT03427_0089(bioC)
CLR : UPTC16701_1352(bioC)
CLM : UPTC16712_1376(bioC)
CAMR : CAQ16704_1392(bioC)
CHV : CHELV3228_1095(bioC)
CPIN : CPIN18020_0607(bioC)
CAMZ : CVIC12175_0129(bioC)
GBN : GEOBRER4_32980(bioC)
BAYD : BSPP4475_01120(bioC)
COHN : KCTCHS21_53460(bioC)
LFB : C1X05_14230(bioC) C1X05_14270
SYH : Syncc8109_2137(bioC)
LET : O77CONTIG1_02424(bioC)
MFF : MFFC18_50120(bioC_2)
AMUC : Pan181_26950(tam_2)
SDYN : Mal52_50630(bioC_3)
CCOP : Mal65_10110(bioC_2)
VBL : L21SP4_02229(bioC_2)
IPO : Ilyop_0229 Ilyop_2721
BTHO : Btheta7330_01770(bioC)
BCEL : BcellWH2_05181(bioC)
BFC : BacF7301_22065(bioC)
PCRE : NCTC12858_01667(bioC)
PCAG : NCTC12856_01358(bioC)
COPR : Cop2CBH44_06310(bioC)
CFAS : Cfast33896_03860(bioC)
PROC : Ptc2401_02210(bioC_2)
FSI : Flexsi_0610 Flexsi_0785
» show all
Taxonomy
Reference
Authors
Del Campillo-Campbell A, Kayajanian G, Campbell A, Adhya S
Title
Biotin-requiring mutants of Escherichia coli K-12.
Journal
Sequence
Reference
Authors
Rolfe B, Eisenberg MA
Title
Genetic and biochemical analysis of the biotin loci of Escherichia coli K-12.
Journal
Reference
Authors
Otsuka AJ, Buoncristiani MR, Howard PK, Flamm J, Johnson C, Yamamoto R, Uchida K, Cook C, Ruppert J, Matsuzaki J
Title
The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon.
Journal
J Biol Chem 263:19577-85 (1988)
Sequence
Reference
Authors
Cleary PP, Campbell A
Title
Deletion and complementation analysis of biotin gene cluster of Escherichia coli.
Journal
Reference
Authors
Lin S, Hanson RE, Cronan JE
Title
Biotin synthesis begins by hijacking the fatty acid synthetic pathway.
Journal
Sequence
Reference
Authors
Lin S, Cronan JE
Title
The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.197