Entry
Name
tRNA (cytosine34-C5)-methyltransferase;
hTrm4 Mtase;
hTrm4 methyltransferase;
hTrm4 (gene name);
tRNA:m5C-methyltransferase (ambiguous)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytosine34 in tRNA precursor = S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor [RN:
R00595 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
cytosine34 in tRNA precursor
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
5-methylcytosine34 in tRNA precursor
Comment
The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors. The intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors [1].
History
EC 2.1.1.203 created 1976 as EC 2.1.1.29, part transferred 2011 to EC 2.1.1.203
Orthology
K15335 tRNA (cytosine34-C5)-methyltransferase
Genes
CIMI : 108297968 108316245(NSUN2)
PROB : 127220714(Nsun2) 127225602
PCAD : 102980393 102980553(NSUN2)
MJV : 108401277(NSUN2) 118973607
TALA : 104363767 122153950(NSUN2)
SRX : 107711338 107754797(nsun2)
SANH : 107691499 107694333
SGH : 107584336(nsun2) 107595605
CAUA : 113090786 113119539(nsun2)
CGIB : 127935711 127979536
MASI : 127421446 127425461
MSAM : 119884341 119907446
OTW : 112229304 112264511(nsun2)
PSPA : 121312855 121314785
ARUT : 117394658 117400466
LCM : 102349429 102352869(NSUN2)
SCLV : 120337271 120341367
LPIC : 129253763 129253765
DSI : Dsimw501_GD16312(Dsim_EG:EG0007.9)
DYA : Dyak_GE16872(Dyak_EG:EG0007.9)
AALB : 109421722 109425447
MGEN : 117220589 117220608
PMAC : 106707772 106711911
DPTE : 113792124 113794493
CEL : CELE_Y48G8AL.5(nsun-2)
MMER : 123548725 123548804
RPHI : 132719613 132725021 132727781 132757056
DPOL : 127842475 127843701 127844672
VCN : VOLCADRAFT_54934 VOLCADRAFT_56298
OTA : OT_ostta08g01420 OT_ostta14g02040
MIS : MICPUN_59711 MICPUN_66831 MICPUN_79216
MPP : MICPUCDRAFT_15736(JGI:MicpuC2_15736)
NCE : NCER_101435 NCER_101436
MBR : MONBRDRAFT_36363 MONBRDRAFT_38306
ACAN : ACA1_071630 ACA1_189790
CHO : Chro.50016 Chro.70192
TET : TTHERM_00028590 TTHERM_00684540
SMIN : v1.2.013460.t1(symbB.v1.2.013460.t1) v1.2.033994.t1(symbB.v1.2.033994.t1) v1.2.037264.t1(symbB.v1.2.037264.t1)
TPS : THAPSDRAFT_23686 THAPSDRAFT_24350 THAPSDRAFT_39812
PIF : PITG_00448 PITG_02560 PITG_17253 PITG_17298
PSOJ : PHYSODRAFT_248298 PHYSODRAFT_447412 PHYSODRAFT_477678 PHYSODRAFT_551899
SPAR : SPRG_00868 SPRG_04176 SPRG_05360 SPRG_20720 SPRG_21894
EHX : EMIHUDRAFT_194550 EMIHUDRAFT_452763 EMIHUDRAFT_459528 EMIHUDRAFT_96831
GTT : GUITHDRAFT_46333 GUITHDRAFT_55503 GUITHDRAFT_62957 GUITHDRAFT_82201 GUITHDRAFT_99887
TBR : Tb10.70.0080 Tb927.3.3230
TBG : TbgDal_III3390 TbgDal_X8190
TCR : 506699.3 508153.370 510187.240
LMA : LMJF_29_2540 LMJF_36_2170
LIF : LINJ_29_2650 LINJ_36_2300
LDO : LDBPK_292650 LDBPK_362300
LMI : LMXM_08_29_2540 LMXM_36_2170
LBZ : LBRM_29_2510 LBRM_35_2410
LPAN : LPMP_292550 LPMP_352260
NGR : NAEGRDRAFT_56581 NAEGRDRAFT_80707
TVA : TVAG_2v0135880 TVAG_2v1030680
» show all
Taxonomy
Reference
Authors
Brzezicha B, Schmidt M, Makalowska I, Jarmolowski A, Pienkowska J, Szweykowska-Kulinska Z
Title
Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA).
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.203