KEGG   ENZYME: 2.1.1.206
Entry
EC 2.1.1.206                Enzyme                                 
Name
tRNA (cytidine56-2'-O)-methyltransferase;
aTrm56;
tRNA ribose 2'-O-methyltransferase aTrm56;
PAB1040 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + cytidine56 in tRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
cytidine56 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methylcytidine56 in tRNA
Comment
The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.
History
EC 2.1.1.206 created 2011
Orthology
K07254  tRNA (cytidine56-2'-O)-methyltransferase
Genes
MJA: MJ_1385
MFE: Mefer_0592
MVU: Metvu_0176
MFS: MFS40622_0541
MIF: Metin_0231
MJH: JH146_0372
MESG: MLAUSG7_0296
MESA: MLASG1_1381
MIG: Metig_1799
MMP: MMP1425
MMQ: MmarC5_0153
MMX: MmarC6_1248
MMZ: MmarC7_0670
MMD: GYY_07960
MMAK: MMKA1_16490
MMAO: MMOS7_15320
MMAD: MMJJ_14140
MAE: Maeo_1410
MVN: Mevan_0736
MVO: Mvol_1037
MOK: Metok_0792
METF: CFE53_00130
MTH: MTH_1113
MMG: MTBMA_c14970
MWO: MWSIV6_1505
MTEE: MTTB_02990
METC: MTCT_1007
METE: tca_01069
METZ: METMT2_1133
METK: FVF72_06015
MTHM: FZP57_07200
METJ: FZP68_03475
MST: Msp_1167
METB: AW729_09920
MEIS: PXD04_01795
MRU: mru_1893
MSI: Msm_0932
MEB: Abm4_0323
MMIL: sm9_1882
MEYE: TL18_08850
MOL: YLM1_1348
MARO: MarbSA_15820
METV: K4897_06815
MEL: Metbo_0385
MEW: MSWAN_2023
METH: MBMB1_1643
MFC: BRM9_0897
MFI: DSM1535_0864
MCUB: MCBB_1950
MSUB: BK009_07225
METN: BK008_02870
METT: CIT01_03460
METO: CIT02_09670
MEME: HYG87_04755
MFEG: GCM10025860_02290
MFV: Mfer_0122
MKA: MK0803
AFU: AF_0751
AFG: AFULGI_00008320
APO: Arcpr_0987
AVE: Arcve_1584
AST: Asulf_01684
FPL: Ferp_1796
GAC: GACE_0721
GAH: GAH_02047
PFU: PF0461
PFI: PFC_01420
PHO: PH0461(PH0461)
PAB: PAB1040
PYN: PNA2_1092
PYA: PYCH_18720
PYS: Py04_0643
PYC: TQ32_02215
TKO: TK0060
TON: TON_1167
TGA: TGAM_1164
TSI: TSIB_1085
TBA: TERMP_01227
THE: GQS_09740
THA: TAM4_2086
THM: CL1_1536
TLT: OCC_07621
THS: TES1_1266
TNU: BD01_1130
TEU: TEU_11540
TGY: X802_07940
THV: ADU37_CDS08890
TCH: CHITON_1288
TPEP: A0127_03590
TPIE: A7C91_01275
TGG: A3K92_02410
TCE: A3L02_08790
TBS: A3L01_06495
THH: CDI07_06475
TSL: A3L11_10745
TTD: A3L14_08925
TPRF: A3L09_04035
TRL: A3L10_00045
TPAF: A3L08_09705
THY: A3L12_03570
TIC: FH039_09520
TCQ: TIRI35C_1626
THEM: FPV09_00200
THEI: K1720_08555
PPAC: PAP_07235
MBA: Mbar_A3187
MBY: MSBRM_2288
MBW: MSBRW_1550
MBAR: MSBR2_0124
MBAK: MSBR3_0181
MAC: MA_3241
MMA: MM_0086
MMAZ: MmTuc01_0095
MMJ: MSMAS_1244
MMAC: MSMAC_2592
MVC: MSVAZ_1623
MEK: MSKOL_1552
MLS: MSLAZ_1587
METM: MSMTP_1231
MEF: MSWH1_2025
MEQ: MSWHS_3044
MSJ: MSSAC_1183
MSZ: MSSIH_2778
MSW: MSSIT_2810
MTHR: MSTHT_0155
MTHE: MSTHC_0573
MHOR: MSHOH_2090
MFZ: AOB57_001680
MBU: Mbur_0256
MMET: MCMEM_0873
MELO: J7W08_02605
MMH: Mmah_1277
MHAZ: BHR79_07155
MPOT: BKM01_03405
MEV: Metev_0683
MZH: Mzhil_0676
MPY: Mpsy_0110
MZI: HWN40_05875
MMAV: RE476_02545
MSEB: RE474_12385
MHZ: Metho_1155
MEHF: MmiHf6_06130
MEES: MmiEs2_03910
MTP: Mthe_1667
MCJ: MCON_3465
MHI: Mhar_0634
MHU: Mhun_2799
MRTJ: KHC33_02905
MLA: Mlab_0456
MEM: Memar_1522
MBG: BN140_3042
MEMA: MMAB1_2390
MCHK: MchiMG62_16880
MSUM: OH143_01820
MRC: R6Y96_08050
MPI: Mpet_1609
MEND: L6E24_01865
MEFW: F1737_03795
MAQE: RJ40_00290
MFK: E2N92_02090
MOU: OU421_01045
MESB: L1S32_01955
MANQ: L1994_05315
MBN: Mboo_1277
MFO: Metfor_2030
MPL: Mpal_2011
MPD: MCP_1507
MEZ: Mtc_1741
RCI: LRC271
HAL: VNG_0755C
HSL: OE_2117F(trm56)
HANR: LJ422_03125
HDL: HALDL1_08190
HHB: Hhub_1875(trm56)
HAGS: JT689_04400
HABO: JRZ79_02900
HNO: LT974_04310
HLU: LT972_08550
HALH: HTSR_1132
HHSR: HSR6_1167
HSU: HLASF_1177
HSF: HLASA_1165
HAHS: HSRCO_1393
SALR: FQU85_10930
HALR: EFA46_008115
HJE: HacjB3_11305
HDO: MUK72_09060
HALX: M0R89_16510
HAXZ: M0R88_17060
HAYC: NGM10_14395
HAXY: NGM07_02925
SALI: L593_09495
SAIM: K0C01_00485
HARA: AArcS_0924
HMA: rrnAC0857
HHI: HAH_1495
HHN: HISP_07640
HAB: SG26_15470
HTA: BVU17_07265
HALJ: G9465_11905
HSIN: KDQ40_05990
NPH: NP_4110A(trm56)
NMO: Nmlp_1943(trm56)
NHO: HWV23_05450
NSAL: HWV07_05135
HUT: Huta_0284
HTI: HTIA_0466
HALA: Hrd1104_05730
HASV: SVXHr_1299(atrm56)
HABN: HBNXHr_1283(atrm56)
HMU: Hmuk_2326
HALZ: E5139_14765
HALL: LC1Hm_1493(atrm56)
HAZP: GBQ70_14780
HALI: BV210_14520
HSN: DV733_08295
HDS: HSR122_2094
HRR: HZS55_16130
HPEL: HZS54_18855
HLT: I7X12_19780
HARC: HARCEL1_02315
SSAI: N0B31_03485
HAAD: MW046_10120
HWA: HQ_2492A(trm56)
HWC: Hqrw_2788(trm56)
HVO: HVO_1173(trm56)
HME: HFX_1186
HGI: ABY42_05745
HALE: G3A49_09080
HLS: KU306_10580
HLN: SVXHx_1126(trm56)
HBO: Hbor_20680
HAQ: DU484_08785
HAJ: DU500_08825
HAER: DU502_06110
HRA: EI982_04785
HLM: DV707_11140
HALM: FCF25_13875
HLA: Hlac_1701
HALP: DOS48_08510
HALB: EKH57_14925
HEZZ: EO776_11385
HALQ: Hrr1229_011765
HSS: J7656_04860
HSAI: HPS36_10130
HAZZ: KI388_09785
SRUB: C2R22_07475
HAE: halTADL_0858
HALN: B4589_004015
HALG: HUG10_06490
HALU: HUG12_10585
HMP: K6T50_05380
HRE: K6T36_05095 K6T36_16395
HRM: K6T25_10845
HACB: Hbl1158_11225
HDF: AArcSl_0328
HAH: Halar_2519
HTU: Htur_0969
HSAL: JMJ58_04095
HAKZ: J0X25_11910
NMG: Nmag_3160(trm56)
HXA: Halxa_2543
NAT: NJ7G_3541
NPE: Natpe_2672
NVR: FEJ81_12335
NPL: FGF80_11985
NAY: HYG81_15520
HALY: HYG82_20495
HJT: DVR14_03340
HLO: J0X27_16775
NGE: Natgr_0523
HRU: Halru_1278
SAWL: NGM29_18195
HALV: NGM15_09365
NOU: Natoc_1132
HLR: HALLA_09300
HLC: CHINAEXTREME18705
NAJ: B1756_02900
NAG: AArcMg_1377
NAN: AArc1_2240
NARA: QQ977_04110
NBG: DV706_02730
NAS: GCU68_10815
HDA: BB347_03560
NAC: AQV86_02070
MEAM: MU439_06315
MEAE: QEN48_03830
TAC: Ta0931
TVO: TVG1129508(TVG1129508)
PTO: PTO0696
FAC: FACI_IFERC01G0561
FAI: FAD_1482
CDIV: CPM_1236
TAR: TALC_01531
MAX: MMALV_16540
MER: MMINT_17500
MEAR: Mpt1_c13980
MEUZ: KRP56_00100
ABI: Aboo_0493
ACF: AciM339_0550
APE: APE_2006.1
ACJ: ACAM_1260
SMR: Smar_0917
SHC: Shell_1548
IHO: Igni_1123
IIS: EYM_02835
IPC: IPA_03690
DKA: DKAM_1271
DFD: Desfe_1372
DMU: Desmu_1262
TAG: Tagg_1277
IAG: Igag_0104
THG: TCELL_0275
HBU: Hbut_1137
PDL: Pyrde_1218
PABI: PABY_10630
PARE: PYJP_04690
STO: STK_03330
SOH: D1869_01275
SSO: SSO0267
SOL: Ssol_1245
SSOA: SULA_1286
SSOL: SULB_1287
SSOF: SULC_1285
SSHI: J5U23_03199
SCAS: SACC_01980
SAI: Saci_0653
SACN: SacN8_03155
SACR: SacRon12I_03145
SACS: SUSAZ_02945
SIS: LS215_1972
SIA: M1425_1863
SIM: M1627_1950
SID: M164_1880
SIY: YG5714_1949
SIN: YN1551_0973
SII: LD85_2092
SIH: SiH_1809
SIR: SiRe_1729
SIC: SiL_1723
SULE: GFS03_10250
SULO: GFS33_02065
SULL: EWF20_02725
MSE: Msed_2278
MEMJ: MJ1HA_2603
MCN: Mcup_2024
MHK: DFR87_06875
MPRU: DFR88_06805
MTEN: GWK48_05280
MJN: MjAS7_0572
ABRI: DFR85_07360
SACD: HS1genome_0362
SAZO: D1868_02015
CSTY: KN1_18970
STEP: IC006_1763
SMET: RQ359_000079
SAHS: HS7_08150
TPE: Tpen_0709
THB: N186_04900
TCB: TCARB_0041
THF: MA03_06215
THEL: IG193_04215
ASC: ASAC_0292
ACIA: SE86_02260
CLG: Calag_1284
FFO: FFONT_0828
NMR: Nmar_1606
NIR: NSED_08695
NKR: NKOR_08735
NID: NPIRD3C_0448
NIN: NADRNF5_0279
NIW: Nisw_05860
NCL: C5F47_08420
NOX: C5F49_08305
NUE: C5F50_11680
NIP: NsoK4_00235
NZT: NZOSNM25_000178
NCT: NMSP_1548
NIC: DSQ20_09330
NGA: Ngar_c34950
NVN: NVIE_018330
NEV: NTE_00448
TAA: NMY3_03713
NFN: NFRAN_1002
NCV: NCAV_0128
CSY: CENSYa_1737
CSU: CSUB_C1670
NBV: T478_1324
TAH: SU86_005110
NIU: DSQ19_00930
NDV: NDEV_1964
BARC: AOA65_2251
BARB: AOA66_0957
MARH: Mia14_0749
FLT: Sv326_1102
NCON: LC1Nh_0240(atrm56)
AGW: QT03_C0001G1078
ARG: QT11_C0001G0013
 » show all
Reference
1  [PMID:15987815]
  Authors
Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A
  Title
The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP.
  Journal
RNA 11:1051-63 (2005)
DOI:10.1261/rna.2110805
  Sequence
[pab:PAB1040]
Reference
2  [PMID:18068186]
  Authors
Kuratani M, Bessho Y, Nishimoto M, Grosjean H, Yokoyama S
  Title
Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA.
  Journal
J Mol Biol 375:1064-75 (2008)
DOI:10.1016/j.jmb.2007.11.023
  Sequence
[pho:PH0461]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.206
IUBMB Enzyme Nomenclature: 2.1.1.206
ExPASy - ENZYME nomenclature database: 2.1.1.206
BRENDA, the Enzyme Database: 2.1.1.206

  All links  
Gene (3985)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (399)   
   KEGG MGENES (2886)   
   RefGene (699)   
Protein sequence (3713)   
   UniProt (2692)   
   SWISS-PROT (45)   
   RefSeq(pep) (976)   
DNA sequence (1848)   
   RefSeq(nuc) (1411)   
   GenBank (225)   
   EMBL (212)   
Protein domain (6)   
   InterPro (6)   
All databases (9552)   

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