KEGG   ENZYME: 2.1.1.208
Entry
EC 2.1.1.208                Enzyme                                 
Name
23S rRNA (uridine2479-2'-O)-methyltransferase;
AviRb
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:23S rRNA (uridine2479-2'-O)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + uridine2479 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyluridine2479 in 23S rRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
uridine2479 in 23S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methyluridine2479 in 23S rRNA
Comment
Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine2479-2'-O)-methyltransferase and EC 2.1.1.209 [23S rRNA (guanine2535-N1)-methyltransferase], whose actions confer avilamycin resistance to the RNA.
History
EC 2.1.1.208 created 2011
Orthology
K21514  23S rRNA (uridine2479-2'-O)-methyltransferase
Genes
PSPN: L1F29_13055
CIA: BEN51_12375
CINT: HZF06_08250
RUK: A4V00_07330
AMUR: ADH66_01630
ALAC: JYE50_08815
CBAF: JS518_00585
ACEL: acsn021_26190
NFA: NFA_38300
NFR: ERS450000_00068(rlmB)
NCY: NOCYR_3709
NBR: O3I_029940
NSL: BOX37_20765
NSR: NS506_06087
NOZ: DMB37_08735
NOD: FOH10_19865
NAH: F5544_30145
NAD: NCTC11293_05185(rlmB)
NIE: KV110_28980
NTC: KHQ06_31435
NHU: H0264_30850
NYA: LTV02_02970
NGP: LTT66_24300
NSPU: IFM12276_17260
NYU: D7D52_14510
RHA: RHA1_ro06776
ROP: ROP_67620
ROA: Pd630_LPD03396
RHU: A3Q40_01470(aviRb_1)
RTM: G4H71_19730
RKO: JWS14_36545
ROZ: CBI38_17435
RPSK: JWS13_07640
PDEF: P9209_16430
SPIN: KV203_07465
SALB: XNR_4256
SCB: SCAB_21501
SAMB: SAM23877_4265(aviRb)
SGS: AVL59_20430
SKY: D0C37_22910
SNW: BBN63_16395
SBAT: G4Z16_27840
SMOB: J7W19_17800
SHK: J2N69_31975
SMAO: CAG99_02410
SDEC: L3078_34515
SRUG: F0345_08675
SVIO: HWN34_21480
STUB: MMF93_09545
SDRZ: NEH16_03945
SCT: SCAT_4150(aviRb)
SCY: SCATT_41390
KIS: HUT16_17275
STRI: C7M71_013980
STRH: GXP74_00800
LXL: KDY119_01068
MRN: K8F61_04145
MAZA: NFX31_08430
BCV: Bcav_2329
BFA: Bfae_16290
BRX: BH708_03585
BRV: CFK39_00655
BGG: CFK41_08600
BRZ: CFK38_10795
BSAU: DWV08_05635
BRR: C1N80_10810
BRHA: NLU66_11755
LMOI: VV02_24605
YIM: J5M86_12170
ALX: LVQ62_03325
BEI: GCM100_01040
XCE: Xcel_0332
CET: B8281_00340
CCEU: CBR64_11715
CPRT: FIC82_018305
SANW: G7063_09950
OEK: FFI11_002935
SERJ: SGUI_0689
ORZ: FNH13_16625
OCP: NF557_14380
MICG: GJV80_01805
NOQ: LN652_03640
AER: AERYTH_05690
KFL: Kfla_6197
KQI: F1D05_15680
KSL: OG809_06760
AMAZ: LUW76_02330
SPIQ: OHA34_03880
ACTQ: OG417_42165
SRO: Sros_9079
NCX: Nocox_42145(aviRb)
NFS: OIE67_00870
SACG: FDZ84_32305
KAL: KALB_4297
KUT: JJ691_25330
KBU: Q4V64_26075
AHM: TL08_07510
ACTI: UA75_07235
ACAD: UA74_07240
AHG: AHOG_06960(aviRb1)
ACTA: C1701_04115
STP: Strop_2137
MAU: Micau_0464
MIL: ML5_0438
MICB: MicB006_0478
MTUA: CSH63_22930
MICH: FJK98_28745
MCAB: HXZ27_03965(evdX2)
VMA: VAB18032_26045
MCRA: ID554_00445
VER: HUT12_12350
MENO: Jiend_53760
MCHL: PVK74_23430
MFEU: H1D33_06345
ASE: ACPL_1030
ACTN: L083_1714
AFS: AFR_08460
ACTS: ACWT_0912
AIH: Aiant_51990
ACTR: Asp14428_28260
ACTL: L3i22_008840
AOU: ACTOB_000856
PLK: CIK06_03870
PLAB: C6361_06940
PLAT: C6W10_03510
ATL: Athai_27000
ASER: Asera_47720
PRY: Prubr_35350
DFU: Dfulv_21770
DROS: Drose_26680
DAUR: Daura_23475
NHY: JQS43_21120
CCAZ: COUCH_31130
CAI: Caci_0573
NAV: JQS30_11770
GLY: K3N28_20575
KBB: ccbrp13_36510
DEIN: DAAJ005_09230
LUO: HHL09_22285
TAZ: TREAZ_1845
LBI: LEPBI_I2045
LBF: LBF_1992
 » show all
Reference
1  [PMID:15581897]
  Authors
Mosbacher TG, Bechthold A, Schulz GE
  Title
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.
  Journal
J Mol Biol 345:535-45 (2005)
DOI:10.1016/j.jmb.2004.10.051
  Sequence
[ag:AAG32066]
Reference
2  [PMID:12828631]
  Authors
Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S
  Title
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the  guanosine 2535 base and the uridine 2479 ribose.
  Journal
Mol Microbiol 49:309-18 (2003)
DOI:10.1046/j.1365-2958.2003.03558.x
  Sequence
[ag:AAG32066]
Reference
3  [PMID:11181344]
  Authors
Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A
  Title
An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57.
  Journal
Antimicrob Agents Chemother 45:690-5 (2001)
DOI:10.1128/AAC.45.3.690-695.2001
  Sequence
[ag:AAG32066]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.208
IUBMB Enzyme Nomenclature: 2.1.1.208
ExPASy - ENZYME nomenclature database: 2.1.1.208
BRENDA, the Enzyme Database: 2.1.1.208

  All links  
Gene (273)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (143)   
   KEGG MGENES (82)   
   RefGene (47)   
Protein sequence (481)   
   UniProt (480)   
   SWISS-PROT (1)   
DNA sequence (392)   
   GenBank (200)   
   EMBL (192)   
Protein domain (5)   
   InterPro (5)   
All databases (1151)   

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