S-adenosyl-L-methionine + adenosine1067 in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methyladenosine1067 in 23S rRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
adenosine1067 in 23S rRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
2'-O-methyladenosine1067 in 23S rRNA
Comment
The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton [2].
Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA.