KEGG ENZYME: 2.1.1.234

ENZYME: 2.1.1.234

Entry

EC 2.1.1.234                Enzyme

Name

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase;
DesVI

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase

Reaction(IUBMB)

2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose [RN:R06427]

Reaction(KEGG)

R06427

Substrate

S-adenosyl-L-methionine [CPD:C00019];
dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose

Product

S-adenosyl-L-homocysteine [CPD:C00021];
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose [CPD:C11911]

Comment

The enzyme is involved in the biosynthesis of desosamine, a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics such as erthyromycin, azithromycin, and clarithromycin.

History

EC 2.1.1.234 created 2011

Pathway

ec00523

Polyketide sugar unit biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13311

dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase

K13326

dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase

Genes

SGRF:

SGFS_016240

SCYE:

R2B67_24635

SCAD:

DN051_13790

STIR:

DDW44_27830 DDW44_27885

SKA:	CP970_39725 CP970_39870

SRK:	FGW37_13085

SFIC:

EIZ62_04025

SGAL:

CP966_29020

SCIN:

CP977_27965 CP977_28100

STSU:

B7R87_21945 B7R87_21970

SCHA:

CP983_27960

SGX:	H4W23_25520

SFEU:

IM697_37645

SLIA:

HA039_05655 HA039_05775

STAA:

LDH80_09645

SCAE:

IHE65_08900

STUD:

STRTU_005104

SJN:	RI060_18380

SHAU:

K9S39_40610

SKG:	KJK29_16180

STTN:

BSL84_24965

AER:	AERYTH_15940

TALX:

FOF52_07400 FOF52_14830

NEC:	KGD82_07550

NAKE:

KGD83_01495

NCG:	KGD84_13460

SNAH:

OUQ99_30640

SEN:	SACE_0718(eryCVI)

ACTI:

UA75_17810

ACAD:

UA74_17275

AHG:	AHOG_15450(desVI)

CROS:

N8J89_11380 N8J89_20375

MCAB:

HXZ27_06155(rosL)

MCRA:

ID554_11945

MENO:

Jiend_53120

MCHL:

PVK74_00275

AMS:	AMIS_50600

PSUU:

Psuf_058140 Psuf_058430

DAUR:

Daura_18725

NHY:	JQS43_06915

AEY:	CDG81_13200

IAM:	HC251_01870

FLC:	KJS93_20305

HTB:	MTX78_24625

HVL:	MUN86_07700

» show all

Reference

1 [PMID:12119032]

Authors

Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW

Title

Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine.

Journal

Biochemistry 41:9165-83 (2002)
DOI:10.1021/bi020245j

Sequence

[ag:AAC68678]

Reference

2 [PMID:18327916]

Authors

Burgie ES, Holden HM

Title

Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.

Journal

Biochemistry 47:3982-8 (2008)
DOI:10.1021/bi800063j