Entry
Name
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase;
RavNMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose 3-N,N-dimethyltransferase
Reaction(IUBMB)
2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [RN:
R09821 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose [CPD:
C19947 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
dTDP-3-dimethylamino-3,6-dideoxy-alpha-D-galactopyranose [CPD:
C19948 ]
Comment
The enzyme is involved in the synthesis of dTDP-D-ravidosamine, the amino sugar moiety of the antibiotic ravidomycin V, which is produced by the bacterium Streptomyces ravidus.
History
EC 2.1.1.236 created 2011
Pathway
ec00523 Polyketide sugar unit biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K20682 dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose N,N-dimethyltransferase
Reference
Authors
Kharel MK, Lian H, Rohr J
Title
Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.236