| Entry |
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| Name |
mycinamicin VI 2''-O-methyltransferase;
MycE
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:mycinamicin VI 2''-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III [RN: R09822]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
mycinamicin VI [CPD: C15682]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
mycinamicin III [CPD: C15681]
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| Comment |
The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. Requires Mg2+ for optimal activity.
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| History |
EC 2.1.1.238 created 2011
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| Pathway |
| ec00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K21540 | mycinamicin VI 2''-O-methyltransferase |
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| Reference |
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| Authors |
Li S, Anzai Y, Kinoshita K, Kato F, Sherman DH |
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| Title |
Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.238 |
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