Entry Name L-olivosyl-oleandolide 3-O-methyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:L-olivosyl-oleandolide B 3-O-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + L-olivosyl-oleandolide = S-adenosyl-L-homocysteine + L-oleandrosyl-oleandolide [RN:
R06456 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
L-olivosyl-oleandolide [CPD:
C11991 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
L-oleandrosyl-oleandolide [CPD:
C11992 ]
Comment The enzyme is involved in the biosynthesis of the macrolide antibiotic oleandomycin in Streptomyces antibioticus. It can also act on other monoglycosylated macrolactones, including L-rhamnosyl-erythronolide B and L-mycarosyl-erythronolide B.
History EC 2.1.1.239 created 2012
Pathway ec00522 Biosynthesis of 12-, 14- and 16-membered macrolides
ec01110 Biosynthesis of secondary metabolites
Orthology K13320 L-olivosyl-oleandolide 3-O-methyltransferase
Reference Authors Rodriguez L, Rodriguez D, Olano C, Brana AF, Mendez C, Salas JA
Title Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.239
