| Entry |
|
|---|
| Name |
trans-resveratrol di-O-methyltransferase;
ROMT;
resveratrol O-methyltransferase;
pterostilbene synthase
|
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
|---|
| Sysname |
S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase
|
|---|
| Reaction(IUBMB) |
2 S-adenosyl-L-methionine + trans-resveratrol = 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction) [RN: R09872];
(1a) S-adenosyl-L-methionine + trans-resveratrol = S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene [RN: R09870];
(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene = S-adenosyl-L-homocysteine + pterostilbene [RN: R09871]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
trans-resveratrol [CPD: C03582];
3-methoxy-4',5-dihydroxy-trans-stilbene [CPD: C20154]
|
|---|
| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
pterostilbene [CPD: C10287];
3-methoxy-4',5-dihydroxy-trans-stilbene [CPD: C20154]
|
|---|
| Comment |
The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.
|
|---|
| History |
EC 2.1.1.240 created 2012
|
|---|
| Pathway |
| ec00945 | Stilbenoid, diarylheptanoid and gingerol biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K16040 | trans-resveratrol di-O-methyltransferase |
|
|---|
| Genes |
| VVI: | 100233030(OMT2.1) 100243765 100247173 100247273 100248917 100250627 100254011 100255808 100257423 100259140 100260877 100263651 100854823 132254760 |
| VRI: | 117925800 117925802 117926250 117926260 117926349 117926834 117926835 117926836 |
|
|---|
| Reference |
|
|---|
| Authors |
Schmidlin L, Poutaraud A, Claudel P, Mestre P, Prado E, Santos-Rosa M, Wiedemann-Merdinoglu S, Karst F, Merdinoglu D, Hugueney P |
|---|
| Title |
A stress-inducible resveratrol O-methyltransferase involved in the biosynthesis of pterostilbene in grapevine. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.240 |
|
|---|
