KEGG   ENZYME: 2.1.1.243
Entry
EC 2.1.1.243                Enzyme                                 
Name
2-ketoarginine methyltransferase;
mrsA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:5-carbamimidamido-2-oxopentanoate S-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate = S-adenosyl-L-homocysteine + 5-guanidino-3-methyl-2-oxopentanoate [RN:R09939]
Reaction(KEGG)
R09939
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5-guanidino-2-oxopentanoate [CPD:C03771]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5-guanidino-3-methyl-2-oxopentanoate [CPD:C20234]
Comment
The enzyme is involved in production of the rare amino acid 3-methylarginine, which is used by the epiphytic bacterium Pseudomonas syringae pv. syringae as an antibiotic against the related pathogenic species Pseudomonas syringae pv. glycinea.
History
EC 2.1.1.243 created 2012
Orthology
K16215  2-ketoarginine methyltransferase
Genes
XTHG4Q83_12690
PSBPsyr_0118
BMAEDM78_1594
BPSBPSL1723
BPMBURPS1710b_2150
BPLBURPS1106A_2014
BPDBURPS668_1994
BPRGBP346_A2040
BPSEBDL_243
BPSMBBQ_1583
BPSUBBN_1708
BPSDBBX_2180
BPZBP1026B_I1676
BPQBPC006_I2061
BPKBBK_3207
BPSHDR55_2815
BPSABBU_418
BPSOX996_2438
BUTX994_885
BOKDM82_5248 DM82_5333
BOCBG90_5276 BG90_5361
BUUWS70_22980
BGDbgla_1g16380
BGOBM43_2864
ACHRC2U31_27130
AAVAave_3704
CCROCMC5_053790
NBRO3I_018980
NOZDMB37_02715
SBHSBI_00619
STRMM444_32675
SLAUSLA_6023
SRJSRO_1605
SGFHEP81_01791(mrsA)
SCOECP976_29250
SGKPET44_31115
ACTQOG417_15810
NOABKM31_13715
KBSEPA93_13985
 » show all
Reference
1  [PMID:20190091]
  Authors
Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Volksch B, Spiteller D
  Title
Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93.
  Journal
Appl Environ Microbiol 76:2500-8 (2010)
DOI:10.1128/AEM.00666-09
  Sequence
[psb:Psyr_0118]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.243
IUBMB Enzyme Nomenclature: 2.1.1.243
ExPASy - ENZYME nomenclature database: 2.1.1.243
BRENDA, the Enzyme Database: 2.1.1.243

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