Entry
Name
2-ketoarginine methyltransferase;
mrsA (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5-carbamimidamido-2-oxopentanoate S-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate = S-adenosyl-L-homocysteine + 5-guanidino-3-methyl-2-oxopentanoate [RN:
R09939 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
5-guanidino-2-oxopentanoate [CPD:
C03771 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
5-guanidino-3-methyl-2-oxopentanoate [CPD:
C20234 ]
Comment
The enzyme is involved in production of the rare amino acid 3-methylarginine, which is used by the epiphytic bacterium Pseudomonas syringae pv. syringae as an antibiotic against the related pathogenic species Pseudomonas syringae pv. glycinea.
History
EC 2.1.1.243 created 2012
Orthology
K16215 2-ketoarginine methyltransferase
Genes
» show all
Taxonomy
Reference
Authors
Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Volksch B, Spiteller D
Title
Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.243