KEGG ENZYME: 2.1.1.255

ENZYME: 2.1.1.255

Entry

EC 2.1.1.255                Enzyme

Name

geranyl diphosphate 2-C-methyltransferase;
SCO7701;
GPP methyltransferase;
GPPMT;
2-methyl-GPP synthase;
MGPPS;
geranyl pyrophosphate methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:geranyl-diphosphate 2-C-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + geranyl diphosphate = S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate [RN:R09940]

Reaction(KEGG)

R09940

Substrate

S-adenosyl-L-methionine [CPD:C00019];
geranyl diphosphate [CPD:C00341]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
(E)-2-methylgeranyl diphosphate [CPD:C20235]

Comment

This enzyme, along with EC 4.2.3.118, 2-methylisoborneol synthase, produces 2-methylisoborneol, an odiferous compound produced by soil microorganisms with a strong earthy/musty odour.

History

EC 2.1.1.255 created 2012

Orthology

K16217

geranyl diphosphate 2-C-methyltransferase

Genes

NANN:

O0S08_17690

MMI:

MMAR_1565

MMAE:

MMARE11_14780

MLI:	MULP_01696

MPSE:

MPSD_42820

MSHO:

MSHO_56550

MGOR:

H0P51_02345

MBAI:

MB901379_01390

NBR:	O3I_013630 O3I_015975

NNO:	NONO_c25600

NSR:	NS506_02329 NS506_05723

NTP:	CRH09_13805

NOZ:	DMB37_04605

NOD:	FOH10_09625

NAH:	F5544_16845

NAD:	NCTC11293_03085

NWL:	NWFMUON74_35020 NWFMUON74_46180

NIE:	KV110_12990

NHU:	H0264_17890

NYA:	LTV02_35900

NGP:	LTT66_01315

NSPU:

IFM12276_42350

NYU:	D7D52_22665

RFA:	A3L23_04940 A3L23_04941

SCO:	SCO7701(SCBAC12C8.02)

SMA:	SAVERM_983(gmt)

SGR:

SGR_1268

SANL:

KZO11_31025

SGRF:

SGFS_015740

SCB:

SCAB_5031

SVL:	Strvi_5649

SRC:	M271_41385

SMAL:

SMALA_1170

SSOI:

I1A49_09330

SFA:

Sfla_5666

SBH:

SBI_08956

SVE:

SVEN_7112

SDV:	BN159_8263

STRP:

F750_0932

SCI:	B446_04430

SLV:	SLIV_00795

SVT:	SVTN_32735

STRE:

GZL_00393 GZL_09220

SLD:	T261_00377 T261_0998

SLC:	SL103_24340

STRM:

M444_04655

STRC:

AA958_14460

SAMB:

SAM23877_0410

SPAV:

Spa2297_00465

STRT:

A8713_00475 A8713_31600

SCLF:

BB341_02175

SGS:	AVL59_27415 AVL59_29230 AVL59_39195

STSI:

A4E84_39420

SALW:

CP975_03260

SGM:	GCM10017557_74170

SCAD:

DN051_34580

SLS:	SLINC_0499

SNR:	SNOUR_01180 SNOUR_41455

SALU:

DC74_7953

SALL:

SAZ_41060

SNW:	BBN63_07285

SAUO:

BV401_09620

SSIA:

A7J05_33530

SPUN:

BFF78_28975 BFF78_39080

SGV:	B1H19_05225 B1H19_35420

SLAU:

SLA_6492

SALF:

SMD44_08712(gppmt)

SALJ:

SMD11_0059(gppmt) SMD11_0840(gppmt)

SLX:	SLAV_04740

STRO:

STRMOE7_31120

SFK:

KY5_0685

SGE:	DWG14_07886

SRJ:

SRO_0471

SGD:	ELQ87_04620

SQZ:	FQU76_30480

SCYA:

EJ357_44450

SKA:	CP970_39575

SGZ:	C0216_28050

SVN:	CP980_02675

SHAW:

CEB94_39490

SRK:	FGW37_01925 FGW37_32360

SFIC:

EIZ62_04920 EIZ62_30010

SPAD:

DVK44_33300

SAQU:

EJC51_43070

SGF:	HEP81_00454

SRIM:

CP984_02510

SSUB:

CP968_00380

SPHV:

F9278_00490

SCIN:

CP977_29570

STSU:

B7R87_30070

SCHA:

CP983_40845

SGX:	H4W23_02770

SBAT:

G4Z16_17835

SSPB:

CP982_40635

SNF:	JYK04_07626

SPLA:

CP981_14280

SBRO:

GQF42_05895

STUI:

GCM10017668_01890

SHUN:

DWB77_01163

SFEU:

IM697_25790

SMOB:

J7W19_26420

SROI:

IAG44_02640

SXN:	IAG42_34305

SGJ:	IAG43_28655

SANU:

K7396_32460

SLF:	JEQ17_04900

SDEC:

L3078_40630

SAOV:

G3H79_01800 G3H79_34960 G3H79_38805

SDUR:

M4V62_02695

SYAN:

NRK68_31500

SAKB:

K1J60_03055

STAA:

LDH80_06870

SNIG:

HEK616_77080

SCAE:

IHE65_04055

STUB:

MMF93_30830

SSPN:

LXH13_02490

SCIR:

STRCI_000421

SXT:	KPP03845_100515

SLON:

LGI35_41045

STUD:

STRTU_004585

SGK:	PET44_03225

SANT:

QR300_37545

SYUN:

MOV08_01425 MOV08_42820

SOV:	QZH56_01765

SKG:	KJK29_37665

SCOA:

QU709_43160

SLAI:

P8A22_06360

SROC:

RGF97_03205

SFP:	QUY26_00840

STTN:

BSL84_31410

SINN:

ABB07_26245 ABB07_34900

KSK:

KSE_70220

KIT:	CFP65_0948 CFP65_1068 CFP65_6968

KIS:	HUT16_33515

YIA:	LO772_33750

STRH:

GXP74_19765 GXP74_21590 GXP74_27015

ABRY:

NYE86_25315

AGLA:

OIE69_40510

NDA:

Ndas_2619

NAL:	B005_4058(gdpmt)

NEX:	NE857_13505

NEC:	KGD82_17070

NAKE:

KGD83_12570

NCG:	KGD84_21195

SNAH:

OUQ99_11120

ACTW:

F7P10_26545

AGRA:

AGRA3207_007830

AMAZ:

LUW76_36555

ACIR:

OG979_09480

ACTQ:

OG417_08205

NOA:	BKM31_10720

NOW:	GBF35_07425

NGN:	LCN96_30655

NFS:	OIE67_17570

SEN:

SACE_3721

SACG:

FDZ84_36945

AMD:

AMED_3241

AMN:

RAM_16485

AMM:

AMES_3206

AMZ:

B737_3206

AOI:

AORI_4063

AJA:	AJAP_18585

AMYC:

CU254_16065

AMYB:

BKN51_13195

AAB:	A4R43_03955

AMYY:

YIM_17000

AORI:

SD37_20730

APRT:

MUY14_19215

AROO:

NQK81_00540

APRE:

CNX65_18475

SESP:

BN6_41360

SSYI:

EKG83_30425

KAL:

KALB_4604

KUT:	JJ691_11930

KPHY:

AOZ06_24425

LED:	BBK82_32015

ALO:

CRK56092

CROS:

N8J89_36200

UME:	RM788_47970

ASE:

ACPL_2024

ACTS:

ACWT_1902

AIH:	Aiant_63910

ACTL:

L3i22_020280

ASIC:

Q0Z83_001880

AOU:	ACTOB_001989

ATL:	Athai_37790

CAI:

Caci_4613

SNA:

Snas_1990

» show all

Reference

1 [PMID:18563898]

Authors

Wang CM, Cane DE

Title

Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor.

Journal

J Am Chem Soc 130:8908-9 (2008)
DOI:10.1021/ja803639g

Sequence

[sco:SCO7701]

Reference

2 [PMID:21393856]

Authors

Ariyawutthiphan O, Ose T, Tsuda M, Gao Y, Yao M, Minami A, Oikawa H, Tanaka I

Title

Crystallization and preliminary X-ray crystallographic study of a methyltransferase involved in 2-methylisoborneol biosynthesis in Streptomyces lasaliensis.

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun 67:417-20 (2011)
DOI:10.1107/S1744309110051523

Reference

3 [PMID:18492804]

Authors

Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H

Title

Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol.

Journal

Proc Natl Acad Sci U S A 105:7422-7 (2008)
DOI:10.1073/pnas.0802312105

Sequence

[sen:SACE_3721] [ag:BAI77524]