KEGG   ENZYME: 2.1.1.256
Entry
EC 2.1.1.256                Enzyme                                 
Name
tRNA (guanine6-N2)-methyltransferase;
methyltransferase Trm14;
m2G6 methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + guanine6 in tRNA = S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
Substrate
S-adenosyl-L-methionine [CPD:C00019];
guanine6 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:C00021];
N2-methylguanine6 in tRNA
Comment
The enzyme specifically methylates guanine6 at N2 in tRNA.
History
EC 2.1.1.256 created 2012
Orthology
K16318  tRNA (guanine6-N2)-methyltransferase
Genes
VPN: A21D_00895
GRC: GI584_17280
POW: IJ21_04720
NTR: B0W44_04050
RUK: A4V00_11050
AMUR: ADH66_17365
ERZ: ER308_09205
NBR: O3I_033725
NTP: CRH09_34030
NWL: NWFMUON74_30740
STRC: AA958_15410
SLS: SLINC_0280
SCYA: EJ357_20025
BFA: Bfae_15560
BRX: BH708_03225
BRV: CFK39_00310
BGG: CFK41_08970
BRZ: CFK38_11175
BSAU: DWV08_05270
YIM: J5M86_09725
CFL: Cfla_0171
CFI: Celf_0273
CGA: Celgi_3077
CEZ: CBP52_13230
CELZ: E5225_16275
CEJ: GC089_17330
CELH: GXP71_17800
HALT: IM660_06740
RHAL: LQF10_08485
MICG: GJV80_16125
KFL: Kfla_1517 Kfla_3965
NOA: BKM31_57935
NOW: GBF35_38510
CROS: N8J89_15720
MCAB: HXZ27_03915(evdX1)
PLAB: C6361_20025
PLAT: C6W10_23735
PFLA: Pflav_082010
PSUU: Psuf_044820
SNA: Snas_6055
HAO: PCC7418_2648
ENN: FRE64_06885
RRS: RoseRS_2801
RCA: Rcas_2582
CAG: Cagg_1026
HAU: Haur_3569
PBF: CFX0092_A2573
KBS: EPA93_19665 EPA93_20740
TTR: Tter_0020 Tter_0253
DGE: Dgeo_1582
DDR: Deide_03840
DMR: Deima_2803
DGO: DGo_CA1234
DPD: Deipe_0953
DSW: QR90_03835
DCH: SY84_11645
DAB: AUC44_02900
DPU: SU48_02735
DEIN: DAAJ005_07240
DGA: DEGR_05270
TRA: Trad_0388
TTH: TT_C1157
TTJ: TTHA1521(TTHA1521)
TTS: Ththe16_1542
TTL: TtJL18_0521
GES: VT84_36315
GOG: C1280_29375
GMS: SOIL9_65340
TIM: GMBLW1_03740
LRS: PX52LOC_04222
FTJ: FTUN_3848
ULI: ETAA1_46650
TSPH: KIH39_05570
STA: STHERM_c21710
SFC: Spiaf_1295
TAZ: TREAZ_1520
FLI: Fleli_3175
RMR: Rmar_1371
RMG: Rhom172_1425
SRU: SRU_2820
SRM: SRM_03036
TTK: TST_0098
FSH: Q2T83_10630(trm14)
MJA: MJ_0438
MFE: Mefer_0982
MVU: Metvu_0180
MFS: MFS40622_1705
MIF: Metin_1016
MJH: JH146_1351
MESG: MLAUSG7_1461(trm)
MESA: MLASG1_1003(trm)
MIG: Metig_0118
MTEE: MTTB_07670
METZ: METMT2_0560
MFV: Mfer_0655
MKA: MK0969
AFU: AF_2178
AFG: AFULGI_00024490
APO: Arcpr_1458
FPL: Ferp_1541
GAH: GAH_00519
PFU: PF1002
PFI: PFC_04240
PHO: PH0644(PH0644)
PAB: PAB0923
PYN: PNA2_1264
PYA: PYCH_10370
PYS: Py04_1110
PYC: TQ32_04700
TKO: TK1863
TON: TON_1671
TGA: TGAM_0202
TSI: TSIB_1962
TBA: TERMP_01891
THE: GQS_06995
THA: TAM4_1322
THM: CL1_1031
TLT: OCC_10594
THS: TES1_1851
TNU: BD01_1790
TEU: TEU_02565
TGY: X802_04980
THV: ADU37_CDS20960
TCH: CHITON_0638
TPEP: A0127_05895
TPIE: A7C91_03765
TGG: A3K92_08665
TCE: A3L02_07255
TBS: A3L01_09225
THH: CDI07_09165
TSL: A3L11_02720
TTD: A3L14_00270
TPRF: A3L09_01145
TRL: A3L10_08680
TPAF: A3L08_02145
THY: A3L12_00080
TIC: FH039_00825
TCQ: TIRI35C_2181
THEM: FPV09_09040
THEI: K1720_02575
PPAC: PAP_00370
RCI: RCIX1177
SAIM: K0C01_00935
NPH: NP_0864A(trm14)
NMO: Nmlp_3856(trm14)
ABI: Aboo_0151
ACF: AciM339_0896
APE: APE_0557
ACJ: ACAM_0426
SMR: Smar_0628
SHC: Shell_0163
IHO: Igni_0818
IIS: EYM_05845
IAG: Igag_1278
HBU: Hbut_1654
PFM: Pyrfu_0172
PDL: Pyrde_0523
PABI: PABY_02770(trm14)
PARE: PYJP_14730(trm14)
PAI: PAE3215
PIS: Pisl_0408
PCL: Pcal_1100
PAS: Pars_1254
PYR: P186_1525
POG: Pogu_0968
TNE: Tneu_1720
PYW: PYWP30_01839
TTN: TTX_1069
TUZ: TUZN_0760
VDI: Vdis_0007
VMO: VMUT_0894
TPE: Tpen_0555
THB: N186_04280
TCB: TCARB_1883
THEL: IG193_05280
NCV: NCAV_1216
CSU: CSUB_C1144
KCR: Kcr_0662
BARC: AOA65_1404
NEQ: NEQ522
 » show all
Reference
1  [PMID:21693558]
  Authors
Menezes S, Gaston KW, Krivos KL, Apolinario EE, Reich NO, Sowers KR, Limbach PA, Perona JJ
  Title
Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14.
  Journal
Nucleic Acids Res 39:7641-55 (2011)
DOI:10.1093/nar/gkr475
  Sequence
[mja:MJ_0438]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.256
IUBMB Enzyme Nomenclature: 2.1.1.256
ExPASy - ENZYME nomenclature database: 2.1.1.256
BRENDA, the Enzyme Database: 2.1.1.256

  All links  
Gene (267)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (183)   
   KEGG MGENES (70)   
   RefGene (13)   
Protein sequence (183)   
   UniProt (27)   
   SWISS-PROT (7)   
   RefSeq(pep) (149)   
DNA sequence (231)   
   RefSeq(nuc) (195)   
   GenBank (19)   
   EMBL (17)   
Protein domain (5)   
   InterPro (5)   
All databases (686)   

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