KEGG ENZYME: 2.1.1.260

ENZYME: 2.1.1.260

Entry

EC 2.1.1.260                Enzyme

Name

rRNA small subunit pseudouridine methyltransferase Nep1;
Nep1;
nucleolar essential protein 1

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:18S rRNA (pseudouridine1191-N1)-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + pseudouridine1191 in yeast 18S rRNA = S-adenosyl-L-homocysteine + N1-methylpseudouridine1191 in yeast 18S rRNA

Substrate

S-adenosyl-L-methionine [CPD:C00019];
pseudouridine1191 in yeast 18S rRNA

Product

S-adenosyl-L-homocysteine [CPD:C00021];
N1-methylpseudouridine1191 in yeast 18S rRNA

Comment

This enzyme, which occurs in both prokaryotes and eukaryotes, recognizes specific pseudouridine residues (Psi) in small subunits of ribosomal RNA based on the local RNA structure. It recognizes Psi914 in 16S rRNA from the archaeon Methanocaldococcus jannaschii, Psi1191 in yeast 18S rRNA, and Psi1248 in human 18S rRNA.

History

EC 2.1.1.260 created 2012

Orthology

K14568

rRNA small subunit pseudouridine methyltransferase Nep1

Genes

HSA:	10436(EMG1)

PTR:	451806(EMG1)

PPS:	100993485(EMG1)

GGO:	101139632(EMG1)

PON:	100450148(EMG1)

NLE:	100598500(EMG1)

HMH:	116472617(EMG1)

MCC:	722122(EMG1)

MCF:	102135921(EMG1)

MTHB:

126930472

MNI:	105484218(EMG1)

CSAB:

103218495(EMG1)

CATY:

105583049(EMG1)

PANU:

101004238(EMG1)

TGE:	112635586(EMG1)

MLEU:

105541814(EMG1)

RRO:	104680082(EMG1)

RBB:	108542028(EMG1)

TFN:	117090598(EMG1)

PTEH:

111555962(EMG1)

CANG:

105519130(EMG1)

CJC:	100411554(EMG1)

SBQ:	101036212(EMG1)

CIMI:

108294992(EMG1)

CSYR:

103252210(EMG1)

MMUR:

105868988(EMG1)

LCAT:

123640088(EMG1)

PCOQ:

105805034(EMG1)

OGA:	100948224(EMG1)

MMU:	14791(Emg1)

MCAL:

110296069(Emg1)

MPAH:

110315975(Emg1)

RNO:	312706(Emg1)

MCOC:

116099569(Emg1)

ANU:	117715136(Emg1)

MUN:	110548607(Emg1)

CGE:	100759485(Emg1)

MAUA:

101822902(Emg1)

PROB:

127213045(Emg1)

PLEU:

114708773(Emg1)

MORG:

121435343(Emg1)

MFOT:

126514926

AAMP:

119806857(Emg1)

NGI:	103727489(Emg1)

HGL:	101726764(Emg1)

CPOC:

100722865(Emg1)

CCAN:

109682816(Emg1)

DSP:	122101957(Emg1)

NCAR:

124981993

MMMA:

107154930(Emg1)

OCU:

100342038

OPI:	101518828(EMG1)

TUP:	102497301(EMG1)

GVR:	103586396(EMG1)

CFA:	477708(EMG1)

CLUD:

112675375(EMG1)

VVP:	112917321(EMG1)

VLG:	121479031 121479933(EMG1)

NPO:	129503356(EMG1)

AML:	100473024(EMG1)

UMR:	103656178(EMG1)

UAH:	113257948(EMG1)

UAR:	123781538(EMG1)

ELK:

111159741

LLV:

125106464

MPUF:

101677153(EMG1)

MNP:	132019901(EMG1)

MLK:	131838479(EMG1)

NVS:	122892241(EMG1)

ORO:	101375618(EMG1)

EJU:	114222495(EMG1)

ZCA:	113922156(EMG1)

MLX:	118025716(EMG1)

NSU:	110580865(EMG1)

LWW:	102735684(EMG1)

FCA:	101088173(EMG1)

PYU:	121021917(EMG1)

PCOO:

112867570(EMG1)

PBG:	122472395(EMG1)

PVIV:

125170247(EMG1)

LRUF:

124501755

PTG:	102949816(EMG1)

PPAD:

109276093(EMG1)

PUC:

125918797

AJU:

106965340

HHV:	120220422(EMG1)

BTA:	515362(EMG1)

BOM:	102285025(EMG1)

BIU:	109558905(EMG1)

BBUB:

102391692(EMG1)

BBIS:

104992165(EMG1)

CHX:	102189562(EMG1)

OAS:	101108377(EMG1)

BTAX:

128047683(EMG1)

ODA:	120858751(EMG1)

CCAD:

122423319(EMG1)

MBEZ:

129535796(EMG1)

SSC:	100627558(EMG1)

CFR:	102513682(EMG1)

CBAI:

105075426(EMG1)

CDK:	105098190(EMG1)

VPC:	102533764(EMG1)

BACU:

103004463(EMG1)

BMUS:

118901658(EMG1)

LVE:	103086149(EMG1)

OOR:	101290483(EMG1)

DLE:	111176707(EMG1)

PCAD:

102987098(EMG1)

PSIU:

116760135(EMG1)

NASI:

112391727(EMG1)

ECB:	100052984(EMG1)

EPZ:	103547029(EMG1)

EAI:	106847312(EMG1)

MYB:	102255915(EMG1) 102259485

MYD:	102754127(EMG1)

MMYO:

118652149(EMG1) 118669435

MLF:	102432903(EMG1) 102437341

PKL:	118730588(EMG1)

EFUS:

103289038(EMG1)

MNA:	107544067(EMG1)

DRO:	112321653(EMG1)

SHON:

119002528(EMG1)

AJM:	119065668(EMG1)

PDIC:

114513687(EMG1)

PHAS:

123810600(EMG1)

MMF:	118623868(EMG1)

PPAM:

129085048(EMG1)

HAI:	109373661(EMG1)

RFQ:	117028520(EMG1)

PALE:

102896616(EMG1)

PGIG:

120611677(EMG1)

PVP:	105295939(EMG1)

RAY:	107519815(EMG1)

MJV:	108384829(EMG1)

TOD:	119247761(EMG1)

SARA:

101549821(EMG1)

SETR:

126006624(EMG1)

LAV:	100677554(EMG1)

TMU:

101358623

ETF:	101662776(EMG1)

DNM:	101437892(EMG1)

MDO:	100014133(EMG1)

GAS:	123250433(EMG1)

SHR:	100916926(EMG1)

AFZ:

127538873

PCW:	110213737(EMG1)

OAA:	114807788(EMG1)

GGA:	418292(EMG1)

PCOC:

116240010(EMG1)

MGP:	100549249(EMG1)

CJO:	107318472(EMG1)

TPAI:

128089896(EMG1)

LMUT:

125685363(EMG1)

NMEL:

110398288(EMG1)

APLA:

101795903(EMG1)

ACYG:

106047841(EMG1)

CATA:

118247562(EMG1)

AFUL:

116501529(EMG1)

TGU:	100223062(EMG1)

LSR:	110480848(EMG1)

SCAN:

103827164(EMG1)

PMOA:

120506358(EMG1)

OTC:	121339191(EMG1)

PRUF:

121351523(EMG1)

GFR:	102042844(EMG1)

FAB:	101812607(EMG1)

OMA:	130250673(EMG1)

PHI:	102109724(EMG1)

PMAJ:

107207111(EMG1)

CCAE:

111943069(EMG1)

CCW:	104687228(EMG1)

CBRC:

103613960(EMG1)

ETL:	114058148(EMG1)

ZAB:	102071764(EMG1)

ACHL:

103804629(EMG1)

SVG:	106857865(EMG1)

MMEA:

130574794(EMG1)

HRT:	120748716(EMG1)

FPG:	101914863(EMG1)

FCH:	102054948(EMG1)

CLV:	102093025(EMG1)

EGZ:	104126542(EMG1)

NNI:	104009765(EMG1)

PCRI:

104032054(EMG1)

PLET:

104615068(EMG1)

PCAO:

104047337(EMG1)

ACUN:

113479869(EMG1)

TALA:

104361019(EMG1)

PADL:

103921899(EMG1)

AFOR:

103905507(EMG1)

ACHC:

115343497(EMG1)

HALD:

104311655(EMG1)

HLE:	104831781(EMG1)

AGEN:

126049019

GCL:

127025628

CCRI:

104161372(EMG1)

CMAC:

104481545(EMG1)

MUI:	104543682(EMG1)

BREG:

104643451(EMG1)

FGA:	104071235(EMG1)

GSTE:

104252174(EMG1)

LDI:	104342895(EMG1)

MNB:	103781924(EMG1)

OHA:	104327132(EMG1)

NNT:	104410201(EMG1)

SHAB:

115601500(EMG1)

DPUB:

104299455(EMG1)

PGUU:

104466484(EMG1)

ACAR:

104521236(EMG1)

CPEA:

104389454(EMG1)

AVIT:

104272664(EMG1)

CVF:	104292933(EMG1)

RTD:	128904227(EMG1)

CUCA:

104064360(EMG1)

TEO:	104382483(EMG1)

BRHI:

104491854(EMG1)

AAM:	106497214(EMG1)

AROW:

112972992(EMG1)

NPD:	112945594(EMG1)

TGT:	104565658(EMG1)

DNE:	112991069(EMG1)

SCAM:

104150754(EMG1)

ASN:	102376748(EMG1)

AMJ:	102572198(EMG1)

CPOO:

109319378(EMG1)

GGN:	109304345(EMG1)

PSS:	102450259(EMG1)

CMY:	102932916(EMG1)

CCAY:

125622778(EMG1)

DCC:	119850445(EMG1)

CPIC:

101943638(EMG1)

TST:	117885660(EMG1)

CABI:

116821044(EMG1)

MRV:	120401931(EMG1)

ACS:	100560328 103280624

ASAO:

132767527(EMG1)

PVT:	110084642(EMG1)

SUND:

121920956(EMG1)

PBI:	103066098(EMG1)

PMUR:

107285814(EMG1)

CTIG:

120306112(EMG1)

TSR:	106553277(EMG1)

PGUT:

117661831(EMG1)

APRI:

131193690(EMG1)

PTEX:

113444545(EMG1)

NSS:	113424523(EMG1)

VKO:	123033180(EMG1)

PMUA:

114587357(EMG1)

PRAF:

128404601(EMG1)

ZVI:	118097602(EMG1)

HCG:	128342837(EMG1)

GJA:	107116806(EMG1)

STOW:

125436266(EMG1)

EMC:	129345385(EMG1)

XLA:	108696043(emg1.L) 108697334(emg1.S)

XTR:	100485133(emg1)

NPR:	108784386(EMG1)

RTEM:

120946620(EMG1)

BBUF:

121004156(EMG1)

BGAR:

122940698(EMG1)

MUO:	115457829(EMG1)

GSH:	117350139(EMG1)

DRE:	678588(emg1)

SRX:	107744679 107748863 107748869

SANH:

107685516 107699927

SGH:	107569993(emg1)

CCAR:

109105743(emg1)

CAUA:

113060146 113116236

CGIB:

127975197 128030988

PTET:

122360560(emg1)

LROH:

127179187(emg1)

OMC:	131522007(emg1)

PPRM:

120494997 120495047(emg1)

RKG:	130070463(emg1)

MAMB:

125243315(emg1)

CIDE:

127497870

MASI:

127452743 127453765

TROS:

130558141(emg1)

TDW:	130433049(emg1)

MANU:

129448119(emg1)

IPU:

108268384

IFU:	128610705(emg1)

PHYP:

113533958(emg1)

SMEO:

124384424(emg1)

TFD:	113644418(emg1)

TVC:	132845865(emg1)

AMEX:

103028869(emg1)

CMAO:

118817764(emg1)

EEE:	113575284(emg1)

CHAR:

105901683(emg1)

TRU:	101066424 115250384

TFS:	130533030(emg1)

TNG:	GSTEN00015344G001

LCO:	104929009(emg1)

TBEN:

117494773(emg1)

CGOB:

115021055(emg1)

PGEO:

117461126(emg1)

GACU:

117547996(emg1)

EMAC:

134861294(emg1)

ELY:	117265924(emg1)

EFO:	125893165(emg1)

PLEP:

121945294(emg1)

SLUC:

116049693(emg1)

ECRA:

117946310(emg1)

ESP:	116691304(emg1)

PFLV:

114557523(emg1)

GAT:	120810868(emg1)

PPUG:

119197275(emg1)

AFB:	129109573(emg1)

CLUM:

117745491(emg1)

PSWI:

130213483(emg1)

MSAM:

119897453(emg1)

SCHU:

122882089(emg1)

CUD:	121513802(emg1)

ALAT:

119006378(emg1)

MZE:	101473610(emg1)

ONL:	100709353(emg1)

OAU:	116323809(emg1)

OLA:	101172018(emg1)

OML:	112143716(emg1)

CSAI:

133434609(emg1)

XMA:	102217413(emg1)

XCO:	114141663(emg1)

XHE:	116717136(emg1)

PRET:

103478015(emg1)

PFOR:

103136727(emg1)

PLAI:

106955757(emg1)

PMEI:

106921367(emg1)

GAF:	122831027(emg1)

PPRL:

129371229(emg1)

CVG:	107082195(emg1)

CTUL:

119783175(emg1)

GMU:	124862618(emg1)

NFU:	107379442(emg1)

KMR:	108235446(emg1)

ALIM:

106520473(emg1)

NWH:	119409358(emg1)

AOCE:

111564290(emg1)

MCEP:

125016601(emg1)

CSEM:

103387936(emg1)

POV:	109633325(emg1)

SSEN:

122774424(emg1)

HHIP:

117776831(emg1)

HSP:	118113240(emg1)

SMAU:

118315493(emg1)

LCF:

108887348

SDU:	111230097(emg1)

SLAL:

111669943(emg1)

XGL:	120784125(emg1)

HCQ:	109515374(emg1)

SSCV:

125975796

SBIA:

133500742(emg1)

PEE:	133402079(emg1)

PTAO:

133479987(emg1)

BPEC:

110163013(emg1)

MALB:

109966212(emg1)

BSPL:

114842965(emg1)

SJO:	128365868(emg1)

SASA:

106575899 106576677(emg1)

STRU:

115177068 115188117

OTW:	112222507 112225964(emg1)

OMY:	110509324 110537348

OGO:	123998131 124005668(emg1)

ONE:

115140764

OKI:	109883114 109906070

OKE:	118367907 118379505

SALP:

111978624 112073656

SNH:	120031278 120047726(emg1)

CCLU:

121542993(emg1) 121586221

ELS:	105019061(emg1)

SFM:	108925023(emg1)

PKI:	111833958(emg1)

AANG:

118226413(emg1)

LOC:	102692248(emg1)

PSPA:

121296621(emg1)

ARUT:

117425251(emg1)

PSEX:

120535706(emg1)

LCM:	102355452(EMG1)

BFO:

118426063

BBEL:

109466448

CIN:

100184403

SCLV:

120335393 120335662

SPU:

589275

LPIC:

129254841

APLC:

110985399

AJC:

117111088

SKO:

100378866

DME:	Dmel_CG3527(CG3527)

DER:

6550922

DSE:

6612496

DSI:	Dsimw501_GD16696(Dsim_GD16696)

DYA:	Dyak_GE16352

DAN:

6503800

DSR:

110181576

DPO:

4815756

DPE:

6600114

DMN:

108155204

DWI:

6652931

DGR:

6569267

DMO:	Dmoj_GI15406

DAZ:

108619872

DNV:

108657596

DHE:

111604046

DVI:

6633298

CCAT:

101453607

BOD:

106618238

BDR:

105232007

RZE:	108364049 108381676

AOQ:

129238515

TDA:

119668232

MDE:

101895994

SCAC:

106084172

LCQ:

111686165

LSQ:

119602879

GFS:

119635198

ECOE:

129941088

CLON:

129611400

HIS:

119653886

AGA:

1273153

ACOZ:

120948083

AARA:

120898131

AMER:

121588185

ASTE:

118503258

AFUN:

125775085

AMOU:

128298979

AALI:

118460096

AAG:

5573604

AALB:

109398887

CQU:	CpipJ_CPIJ004309

CPII:

120422062

CNS:

116350665

BCOO:

119076140

AME:

409857

ACER:

107998107

ALAB:

122712299

ADR:

102679051

AFLR:

100871213

BIM:

100744183

BBIF:

117206018

BVK:

117238122

BVAN:

117154070

BTER:

100650006

BAFF:

126916277

BPYO:

122565736

BPAS:

132905224

FVI:

122533269

OBB:

114878211

OLG:

117605234

MGEN:

117218679

NMEA:

116428845

CGIG:

122398520

SOC:

105201670

MPHA:

105839821

AEC:

105144983

ACEP:

105622451

PBAR:

105432227

VEM:

105564693

HST:

105186160

DQU:

106749223

CFO:

105250085

FEX:	115238550 115238575

LHU:

105668151

PGC:

109854455

OBO:

105275057

PCF:

106789077

PFUC:

122520108

VPS:

122631549

VCRB:

124427155

VVE:

124952187

NVI:

100680224

CSOL:

105364172

TPRE:

106648433

LHT:

122504610

LBD:

127284473

MDL:	103574456 103574474

CGLO:

123261087 123261102

FAS:

105264274

DAM:

107038128

AGIF:

122847685

CINS:

118070688

VCAN:

122410484

CCIN:

107274229

DSM:

124409939

NPT:

124217516

NFB:

124180117

NLO:

107221576

NVG:

124302917

AROA:

105684301

TCA:

664400

DPA:

109539687

SOY:

115888332

AGRG:

126733874

ATD:

109595394

CSET:

123314946 123319951

AGB:

108912042

LDC:

111515047

NVL:

108566853

APLN:

108738995

PPYR:

116163644

OTU:

111417218

BMOR:

100862801(Nep1)

BMAN:

114242935

MSEX:

115452379

DPL:	KGM_213085

BANY:

112055420

MJU:

123864164

NIQ:

126775766

VCD:

124537185

MCIX:

123660978

PMAC:

106719614

PPOT:

106108059

PXU:

106117034

PRAP:

111004291

PBX:

123706834

PNAP:

125055842

ZCE:

119830024

CCRC:

123702024

LSIN:

126971736

AAGE:

121729328

HAW:

110374475

HZE:

124640345

TNL:

113492521

SLIU:

111354890

OFU:

114364637

PXY:

105393037

PGW:

126381930

CFEL:

113384742 113385464

CCRN:

123292352

API:

100164075

DNX:

107165075

AGS:

114121421

RMD:

113550101

ACOO:

126841875

DVT:

126908403

BTAB:

109032366

DCI:

103510565

CLEC:

106667549

HHAL:

106682692

NLU:

111047075

MQU:

128986923

PHU:	Phum_PHUM607930

FOC:

113203444

TPAL:

117654005

ZNE:

110831721

CSEC:

111873364

SGRE:

126284035 126325507

BROR:

134528269

IEL:

124156600

FCD:

110848563

DPX:	DAPPUDRAFT_188726

DMK:

116930654

DPZ:

124343615

PVM:

113815009

PJA:

122263144

PCHN:

125025977

PMOO:

119577031

HAME:

121863615

PCLA:

123754957

CQD:

128693684

PTRU:

123500631

ESN:

126987754

MNZ:

135223831

HAZT:

108683267

EAF:

111699956

LSM:

121115065

TCF:

131888531

PPOI:

119112338

ISC:

8024065

DSV:

119446107

RSAN:

119390061

RMP:

119174044

VDE:

111247385

VJA:

111269434

TUT:

107364932

DPTE:

113796644

DFR:

124491934

PTEP:

107453405

ABRU:

129966140

UDV:

129234462

SDM:

118196808

LPOL:

106471527

PMEO:

129585572

CEL:	CELE_Y39A1A.14(emg-1)

CBR:

CBG_18338

CRQ:	GCK72_010428

NAI:	NECAME_16990

BMY:	BM_BM6449(Bm6449)

LOA:	LOAG_03665

TSP:

Tsp_04549

HRO:	HELRODRAFT_90376

LGI:	LOTGIDRAFT_208870

PVUL:

126824105

PCAN:

112562610

BGT:

106057791

GAE:

121368302

HRF:

124151888

HRJ:

124259247

CRG:

105322332

CVN:

111138173

CANU:

128190114

OED:

125663713

MYI:

110463073

PMAX:

117333428

MCAF:

127710605

MMER:

123534927

RPHI:

132735909 132736221

DPOL:

127847107

OBI:

106867204

OSN:

115217125

LAK:

106175213

SMM:	Smp_002010

SHX:	MS3_00008789(EMG1_1)

OVI:	T265_09140

EGL:

EGR_09960

NVE:

5512875

EPA:

110252361

ATEN:

116305091

ADF:

107332954

AMIL:

114947893

PDAM:

113681679

SPIS:

111326618

DGT:

114516755

XEN:

124434444

HMG:

100209283

HSY:

130623595

TAD:	TRIADDRAFT_30169

AQU:

100639345

ATH:

AT3G57000

ALY:

9314193

CRB:

111830519

CSAT:

104712361 104791988 109124664

EUS:	EUTSA_v10006512mg

BRP:

103841604

BNA:	106368034 106411956

BOE:

106309854

RSZ:

108861721

THJ:	104803263 104824404

CPAP:

110812141 110822583

CIT:

102606709

CIC:	CICLE_v10005540mg

PVY:

116143049

MINC:

123213287 123227677

TCC:	108662772 18594442 18594471 18598769 18606478

GRA:	105763836 105763941

GHI:	107945652 107948147 121210907

GAB:	108477041 108477682

HSYR:

120135536 120139757 120155541 120201532 120201538 120205582

DZI:	111294256 111310622 111310623 111311459

EGR:	104440803 104447254

GMX:	100778294 100788480

GSJ:	114373630 114380405

PVU:	PHAVU_011G027300g

VRA:

106756151

VAR:

108339570

VUN:

114168533

VUM:

124837740

CCAJ:

109788535 109790180 109790183 109790185 109793088 109793402 109805450 109806179 109807195 109809310

APRC:

113848239 113858104 113864443 113869699 113874198

MTR:	11421258 11430617 25495057

TPRA:

123891027 123905353 123911170

CAM:

101499888

PSAT:

127105940

VVO:	131596668 131633777

LJA:	Lj0g3v0059639.1(Lj0g3v0059639.1) Lj0g3v0059639.2(Lj0g3v0059639.2) Lj6g3v1422200.1(Lj6g3v1422200.1)

ADU:	107471582 107473715 107473739 107474632 107484971 107484975

AIP:	107623952 107625027 107625439 107628217 107639564

AHF:	112727072 112727592 112729174 112739287 112743659 112745138 112784833 112795073 112797046 114924650

LANG:

109337047 109338763 109341912

PCIN:

129296662 129300104 129306350 129307213 129307220

QSA:	O6P43_006380

FVE:

101305881

RCN:	112196745 112199439

PPER:

109946556 18771096 18791642 18793068

PMUM:

103319212 103319213 103342954

PAVI:

110744927 110744943 110762181

PDUL:

117613413 117615741 117634802

MDM:	103414257 103414415 103440456 103454576 114825745

MSYL:

126600579 126603499 126610801 126610811 126610824 126628459 126632800

PXB:	103931776 103932168 103937892 103945562 103945563 103945632 103955458 103965430 108867117

ZJU:	107427300 107435882

MNT:

21402317

CSAV:

115701331 115711464 115720769

CSV:	101206369 101219867

CMO:	103486891 103490911

BHJ:	120080981 120081191 120091224

MCHA:

111016653 111018323

CMAX:

111482341

CMOS:

111442430

CPEP:

111790937

RCU:

8258367

JCU:

105634419

HBR:	110667159 110667161

MESC:

110621155

POP:	7464104 7473563

PEU:	105108005 105119554 105127605

PALZ:

118033308 118053091

JRE:

109011590

CILL:

122277526

CAVE:

132162170

QSU:	111988395 112038554 112038560

QLO:	115952369 115958561

TWL:	119998801 120011925

VVI:	100258999 100260745

VRI:	117919638 117929143

SLY:

101260019

SPEN:

107007641 107027793 114075221

SOT:

102578568

SSTN:

125842489

SDUL:

129889378

CANN:

107839120

LBB:	132617048 132623307 132635715

NTA:	107767617 107769397 107807130 107808457 107808458

NSY:	104210861 104215215 104228511

NTO:	104084546 104084548 104100250 104103750

NAU:	109227456 109231110 109233240

INI:

109182399

ITR:

116006201

SIND:

105162595 105171118 105179657

OEU:	111399550 111408237

EGT:

105949183

SSPL:

121747209 121751503 121766546 121768445 121772336

SMIL:

130987205 131022501

SHIS:

125208935 125215112

APAN:

127259599

HAN:	110899425 110930303

ECAD:

122578685

LSV:

111918100

CCAV:

112529877

DCR:	108216134 108216431

CSIN:

114314249 114314250 114314251 114320343

RVL:	131299712 131300084 131300085 131322784

AEW:	130752153 130773214

BVG:	104893948 104895101 109134972

SOE:	110774752 110775425 110777573 110797674

CQI:	110682147 110696460 110696461 110699573 110703171 110711555 110714774 110714937 110714938 110735569

ATRI:

130809736 130809739 130827261

MOF:	131161851 131168429

NNU:

104600899

MING:

122067750 122078735

TSS:

122664558

PSOM:

113275662 113281946

OSA:

4329057

DOSA:

Os02t0290400-01(Os02g0290400)

OBR:

102706254

OGL:

127763039

BDI:

100844288

ATS:	109734717 109781927

TDC:	119316998 119324536 119333589 119338228 119341921

TAES:

123127606 123137347 123144707 123154344 123161461 123162013

TUA:	125512729 125518755

LPER:

127307460

LRD:	124687119 124687120

SBI:	8076240 8077752

ZMA:

100282562

SITA:

101763420

SVS:

117845222

PVIR:

120655469 120675388 120698716 120707651

PHAI:

112893789 112894772

PDA:

103701962

EGU:

105056316

MUS:	103968756 103983473

ZOF:	121969338 121974459

DCT:	110101229 110105926

PEQ:

110020013

AOF:

109829006

MSIN:

131237761

NCOL:

116253565 116254214 116254869

ATR:

18427279

SMO:	SELMODRAFT_115712 SELMODRAFT_407397

PPP:

112276962

CRE:	CHLRE_01g009950v5

VCN:	VOLCADRAFT_106743

MNG:

MNEG_5650

CSL:	COCSUDRAFT_17012

APRO:

F751_6608

OLU:	OSTLU_39810

OTA:	OT_ostta01g00910 OT_ostta18g01680

BPG:	Bathy01g00830

MIS:	MICPUN_77569

MPP:	MICPUCDRAFT_49493(JGI:MicpuC2_49493)

CME:	CYME_CMC063C

GSL:	Gasu_18460

CCP:	CHC_T00000277001

SCE:	YLR186W(EMG1)

SEUB:

DI49_3702

SPAO:

SPAR_L02200

AGO:	AGOS_AFR686C

ERC:

Ecym_1069

KLA:	KLLA0_C01914g

KMX:	KLMA_10085(EMG1)

LTH:	KLTH0F01958g

VPO:	Kpol_2000p81

ZRO:	ZYRO0F17116g

CGR:	CAGL0B01232g

NCS:	NCAS_0A00500(NCAS0A00500)

NDI:	NDAI_0F04300(NDAI0F04300)

TPF:	TPHA_0B04640(TPHA0B04640)

TBL:	TBLA_0A05270(TBLA0A05270)

TGB:	HG536_0B00820

TDL:	TDEL_0C06380(TDEL0C06380)

KAF:	KAFR_0D04030(KAFR0D04030)

KNG:	KNAG_0F00380(KNAG0F00380)

ZMK:	HG535_0A00810

PPA:	PAS_chr1-1_0335

DHA:	DEHA2E14036g

PIC:	PICST_55133

PGU:	PGUG_03307

SPAA:

SPAPADRAFT_58316

LEL:	PVL30_000871(NEP1)

CAL:	CAALFM_C111380WA(NEP1)

CTP:	CTRG_04106

COT:	CORT_0A07260

CDU:	CD36_10670

CTEN:

CANTEDRAFT_113170

YLI:	YALI0E01496g

CLU:	CLUG_02149

CLUS:

A9F13_02g01463

CAUR:

CJI96_0004037

SLB:	AWJ20_1441(EMG1)

PKZ:	C5L36_0A06110

BNN:	FOA43_001563(NEP1)

BBRX:

BRETT_001350(EMG1)

OPA:	HPODL_00411

SLUD:

SCDLUD_003871

NCR:

NCU02428

NTE:	NEUTE1DRAFT85901(NEUTE1DRAFT_85901)

SMP:	SMAC_08316

PAN:	PODANSg9229

PBEL:

QC761_505480(NEP1)

PPSD:

QC762_505480(NEP1)

PPSP:

QC763_505480(NEP1)

PPSA:

QC764_505480(NEP1)

TTT:	THITE_2116796

MTM:	MYCTH_2316023

CTHR:

CTHT_0048280

MGR:

MGG_03587

PPEI:

PpBr36_06726

PGRI:

PgNI_00426

TMN:	UCRPA7_1956

SSCK:

SPSK_00578

FGR:	FGSG_09853

FPU:	FPSE_07637

FPOA:

FPOAC1_011782(EMG1)

FVN:	FVRRES_12842

FVR:	FVEG_05090

FOX:	FOXG_08165

NHE:	NECHADRAFT_59709

FFC:	NCS54_00510500

FKR:	NCS57_00548800

FMU:	J7337_007125(EMG1)

TRE:	TRIREDRAFT_121955

TRR:	M419DRAFT_106196

MAW:

MAC_00120

MAJ:

MAA_04480

PCHM:

VFPPC_08187

CMT:

CCM_01212

AMUS:

LMH87_005796

PTKZ:

JDV02_003680(NEP1)

VAL:	VDBG_09681

VDA:	VDAG_09422

CFJ:	CFIO01_13307

CLUP:

CLUP02_12580

CHIG:

CH63R_11890

SAPO:

SAPIO_CDS4543

ELA:	UCREL1_5632

PFY:	PFICI_03515

SSL:	SS1G_11106

BFU:	BCIN_02g05590(Bcemg1)

MBE:

MBM_03053

PSCO:

LY89DRAFT_589340

GLZ:	GLAREA_10016

ANI:	ANIA_02759

AFM:	AFUA_3G06010

ACT:	ACLA_033960

NFI:	NFIA_071240

AOR:	AO090020000071

ANG:	An11g10540

AFV:	AFLA_010583

ALUC:

AKAW2_80907A(EMG1)

ACHE:

ACHE_70491S(EMG1)

APUU:

APUU_31183A(EMG1)

PCS:	N7525_009225

PDP:	PDIP_00990

POU:	POX_g09072

TMF:	EYB26_009011

TRG:	TRUGW13939_11240

CIM:	CIMG_00497

CPW:	CPC735_057300

URE:	UREG_00534

PBL:	PAAG_05978

PBN:	PADG_12027

ABE:

ARB_07234

TVE:

TRV_03942

AJE:	HCAG_01259

BGH:	BDBG_06754

PNO:	SNOG_12263

PTE:

PTT_13441

BZE:	COCCADRAFT_91362

BSC:	COCSADRAFT_80486

BOR:	COCMIDRAFT_107518

AALT:

CC77DRAFT_981591

ARAB:

EKO05_0009774

ZTR:	MYCGRDRAFT_49453

PFJ:	MYCFIDRAFT_44844

FFU:	CLAFUR5_12710

CBET:

CB0940_05578

BCOM:

BAUCODRAFT_64183

NPA:	UCRNP2_5075

TML:	GSTUM_00005897001

SPO:	SPAC18G6.07c(mra1)

SOM:	SOMG_02745(mra1)

CNE:

CNJ01990

CNB:

CNBJ1480

CNG:	CNAG_04770

CGI:	CGB_I2630C

CDEU:

CNBG_5611

TMS:	TREMEDRAFT_37578

TASA:

A1Q1_06118

CCAC:

CcaHIS019_0404980(NEP1)

TVS:	TRAVEDRAFT_27586

DSQ:	DICSQDRAFT_72980

PCO:	PHACADRAFT_148630 PHACADRAFT_249163

SHS:	STEHIDRAFT_169356

HIR:	HETIRDRAFT_314501

PSQ:	PUNSTDRAFT_76504

ADL:	AURDEDRAFT_75227

FME:	FOMMEDRAFT_110102

GTR:	GLOTRDRAFT_33833

LBC:	LACBIDRAFT_252281

CCI:	CC1G_08243 CC1G_11376

ABP:	AGABI1DRAFT35322(AGABI1DRAFT_35322)

ABV:	AGABI2DRAFT67862(AGABI2DRAFT_67862)

PCUB:

JR316_0005230

MRR:	Moror_2860

E1B28_012594

SCM:	SCHCO_02511131(SCHCODRAFT_02511131)

CPUT:

CONPUDRAFT_53859

SLA:	SERLADRAFT_454381

WSE:	WALSEDRAFT_61022

WIC:	J056_001132

UMA:	UMAG_06195

PFP:	PFL1_06761

SGRA:

EX895_003678

MGL:

MGL_2295

MRT:

MRET_0216

MSYM:

MSY001_2009

PGR:	PGTG_11089

PTRC:

PtA15_11A500

PSTR:

Pst134EA_003427

MLR:	MELLADRAFT_38559

ECU:	ECU01_0480

EIN:	Eint_010350

EHE:	EHEL_010340

ERO:	EROM_010260

NCE:	NCER_101666

MBR:	MONBRDRAFT_15167

SRE:	PTSG_03052

DDI:	DDB_G0272732(emg1)

DPP:	DICPUDRAFT_159774

DFA:	DFA_10447(emg1)

EHI:	EHI_044610(3.t00130)

EDI:	EDI_246260

EIV:	EIN_025910

ACAN:

ACA1_173180

PFA:	PF3D7_0821500

PFD:	PFDG_04595

PFH:	PFHG_04997

PREI:

PRSY57_0820800

PGAB:

PGSY75_0821500

PYO:	PY17X_0709500

PCB:	PCHAS_0718400

PBE:	PBANKA_0709300

PVV:	PVVCY_0700910

PKN:	PKNH_1315500

PVX:	PVX_089290

PCY:	PCYB_051970

PMAL:

PMUG01_05024600(NEP1)

PREL:

PRELSG_0502400(NEP1)

TAN:

TA18685

TPV:	TP01_0556 TP03_0619

TOT:	TOT_010000511 TOT_030000270

BEQ:	BEWA_054080

BBO:	BBOV_I002890 BBOV_III002060

BMIC:

BMR1_01G00925 BmR1_04g05655

BBIG:

BBBOND_0205650 BBBOND_0303850

CPV:	cgd4_2830 cgd4_2840

CHO:	Chro.40319

TGO:	TGME49_313980

TET:	TTHERM_00322910

PTM:	GSPATT00008918001 GSPATT00011345001

SMIN:

v1.2.003758.t1(symbB.v1.2.003758.t1)

PTI:	PHATRDRAFT_11653

FCY:	FRACYDRAFT_161986

TPS:	THAPSDRAFT_36986

AAF:	AURANDRAFT_6205 AURANDRAFT_7809

PIF:	PITG_00142

PSOJ:

PHYSODRAFT_506510

SPAR:

SPRG_07725

EHX:	EMIHUDRAFT_313005 EMIHUDRAFT_67063

GTT:	GUITHDRAFT_85573

TBR:	Tb927.2.4980 Tb927.8.5040

TBG:	TbgDal_II2990 TbgDal_VIII4840

TCR:	504741.110 508839.40

LMA:	LMJF_16_1390 LMJF_27_2250

LIF:	LINJ_16_1470 LINJ_27_2170

LDO:	LDBPK_161470 LDBPK_272170

LMI:	LMXM_16_1390 LMXM_27_2250

LBZ:	LBRM_16_1450 LBRM_27_2430

LPAN:

LPMP_161360 LPMP_272250

NGR:	NAEGRDRAFT_60179

TVA:	TVAG_2v0242350

GLA:	GL50803_005786

CFON:

HZU75_06540

MJA:

MJ_0557

MFE:	Mefer_0800

MVU:	Metvu_1182

MFS:	MFS40622_0325

MIF:	Metin_0076

MJH:	JH146_0180

MESG:

MLAUSG7_0519(nep)

MESA:

MLASG1_0276(nep)

MIG:	Metig_0721

MFV:

Mfer_0273

MKA:	MK0202(mra1)

AFU:

AF_0734

AFG:	AFULGI_00008140

APO:	Arcpr_0385

AVE:	Arcve_0614

AST:	Asulf_01474

FPL:

Ferp_0144

GAC:

GACE_1894

GAH:

GAH_00763

PFU:

PF1262

PFI:

PFC_05525

PHO:	PH1379(PH1379)

PAB:

PAB1852

PYN:

PNA2_1962

PYA:	PYCH_10030

PYS:

Py04_1208

PYC:	TQ32_10625

TKO:

TK0876

TON:

TON_0428

TGA:

TGAM_1419

TSI:

TSIB_0244

TBA:	TERMP_00041

THE:

GQS_03060

THA:

TAM4_1471

THM:

CL1_0260

TLT:

OCC_09656

THS:

TES1_0146

TNU:

BD01_0275

TEU:

TEU_07100

TGY:	X802_10855

THV:	ADU37_CDS01830

TCH:	CHITON_1530

TPEP:

A0127_00700

TPIE:

A7C91_08155

TGG:	A3K92_04160

TCE:	A3L02_09210

TBS:	A3L01_02850

THH:	CDI07_02805

TSL:	A3L11_06805

TTD:	A3L14_04450

TPRF:

A3L09_06710

TRL:	A3L10_03685

TPAF:

A3L08_05830

THY:	A3L12_05905

TIC:	FH039_05190

TCQ:	TIRI35C_0797(nep)

THEM:

FPV09_03990

THEI:

K1720_04295

PPAC:

PAP_01645

MTP:

Mthe_0188

TAC:

Ta1124

TVO:	TVG1248551(TVG1248551)

PTO:

PTO0697

FAC:	FACI_IFERC01G1229

FAI:

FAD_0243

CDIV:

CPM_0725

MER:	MMINT_01680

ABI:

Aboo_0915

ACF:	AciM339_0087

APE:

APE_0502

ACJ:

ACAM_0388

SMR:

Smar_1081

SHC:	Shell_1396

IHO:	Igni_0791 Igni_0919

IIS:	EYM_01575 EYM_02790

IPC:	IPA_03120 IPA_03485

DKA:

DKAM_1117

DFD:	Desfe_1232

DMU:	Desmu_1123

TAG:

Tagg_0926

IAG:

Igag_0468

THG:	TCELL_0373

HBU:	Hbut_0319 Hbut_1592

PFM:	Pyrfu_0092 Pyrfu_0309

PDL:	Pyrde_0473

PABI:

PABY_01970 PABY_22460

PARE:

PYJP_08380 PYJP_14160

STO:	STK_21290(nep1)

SOH:	D1869_11665

SSO:

SSO2226

SOL:

Ssol_0045

SSOA:

SULA_0043

SSOL:

SULB_0044

SSOF:

SULC_0043

SSHI:

J5U23_01035

SCAS:

SACC_20510

SAI:

Saci_0034

SACN:

SacN8_00165

SACR:

SacRon12I_00165

SACS:

SUSAZ_00155

SIS:	LS215_0043

SIA:	M1425_0043

SIM:	M1627_0043

SID:

M164_0043

SIY:	YG5714_0043

SIN:	YN1551_0043

SII:

LD85_0043

SIH:

SiH_0043

SIR:

SiRe_0042

SIC:

SiL_0042

SULA:

BFU36_09775

SULE:

GFS03_01750

SULL:

EWF20_12825

MSE:

Msed_0747

MEMJ:

MJ1HA_0859

MCN:

Mcup_1351

MHK:	DFR87_03495

MPRU:

DFR88_02830

MTEN:

GWK48_08520

MJN:	MjAS7_1518

AHO:

Ahos_2315

AMAN:

B6F84_02585

ABRI:

DFR85_01375

ASUL:

DFR86_02590

AAMB:

D1866_06660

ACIH:

HS5_12150

SAZO:

D1868_09305

CSTY:

KN1_05490

STEP:

IC006_2656

SMET:

RQ359_001636

SAHS:

HS7_06310

PAI:

PAE1979

PIS:

Pisl_1803

PCL:

Pcal_1590

PAS:

Pars_2054

PYR:

P186_0220

POG:

Pogu_0070

TNE:

Tneu_0820

PYW:	PYWP30_00907

CMA:

Cmaq_0625

TTN:

TTX_1734

TUZ:

TUZN_1775

VDI:

Vdis_1824

VMO:

VMUT_0265

VSO:	Vsou_02210

TPE:

Tpen_0557

THB:	N186_04270

TCB:	TCARB_1881

THF:	MA03_07115

THEL:

IG193_05270

ASC:

ASAC_1404

CLG:	Calag_0033

FFO:	FFONT_1267

NMR:

Nmar_1625

NIR:	NSED_08860

NKR:	NKOR_08845

NID:	NPIRD3C_0427(nep)

NIN:	NADRNF5_0255(nep)

NIW:	Nisw_05755

NCL:	C5F47_08525

NOX:	C5F49_08410

NUE:	C5F50_11925

NIP:	NsoK4_00120

NZT:	NZOSNM25_000155

NCT:	NMSP_1568(nep1)

NIC:	DSQ20_09435

NGA:	Ngar_c01160

NVN:	NVIE_024380

NEV:

NTE_03110

TAA:	NMY3_03732

NFN:	NFRAN_1021

NCV:	NCAV_1676(nep)

CSY:	CENSYa_1768

CSU:	CSUB_C0783

NBV:

T478_1339

TAH:	SU86_005375

NIU:	DSQ19_00830

NCK:	QVH35_04395

NDV:	NDEV_1977(nep)

CCAI:

NAS2_1597

KCR:

Kcr_1323

BARC:

AOA65_2162(nep1)

BARB:

AOA66_1168(nep1)

LOKI:

Lokiarch_13800(nep1)

LOB:	NEF87_001156

PSYT:

DSAG12_03202(nep1)

» show all

Reference

1 [PMID:18208838]

Authors

Taylor AB, Meyer B, Leal BZ, Kotter P, Schirf V, Demeler B, Hart PJ, Entian KD, Wohnert J

Title

The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site.

Journal

Nucleic Acids Res 36:1542-54 (2008)
DOI:10.1093/nar/gkm1172

Sequence

[sce:YLR186W]

Reference

2 [PMID:20047967]

Authors

Wurm JP, Meyer B, Bahr U, Held M, Frolow O, Kotter P, Engels JW, Heckel A, Karas M, Entian KD, Wohnert J

Title

The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase.

Journal

Nucleic Acids Res 38:2387-98 (2010)
DOI:10.1093/nar/gkp1189

Sequence

[hsa:10436] [mja:MJ_0557]

Reference

3 [PMID:20972225]

Authors

Meyer B, Wurm JP, Kotter P, Leisegang MS, Schilling V, Buchhaupt M, Held M, Bahr U, Karas M, Heckel A, Bohnsack MT, Wohnert J, Entian KD

Title

The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA.

Journal

Nucleic Acids Res 39:1526-37 (2011)
DOI:10.1093/nar/gkq931

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.260

IUBMB Enzyme Nomenclature:

2.1.1.260

ExPASy - ENZYME nomenclature database:

2.1.1.260

BRENDA, the Enzyme Database:

2.1.1.260

DBGET integrated database retrieval system