KEGG ENZYME: 2.1.1.269

ENZYME: 2.1.1.269

Entry

EC 2.1.1.269                Enzyme

Name

dimethylsulfoniopropionate demethylase;
dmdA (gene name);
dimethylsulfoniopropionate-dependent demethylase A

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S,S-dimethyl-beta-propiothetin:tetrahydrofolate S-methyltransferase

Reaction(IUBMB)

S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate [RN:R10333]

Reaction(KEGG)

R10333

Substrate

S,S-dimethyl-beta-propiothetin [CPD:C04022];
tetrahydrofolate [CPD:C00101]

Product

3-(methylsulfanyl)propanoate [CPD:C08276];
5-methyltetrahydrofolate [CPD:C00440]

Comment

The enzyme from the marine bacteria Pelagibacter ubique and Ruegeria pomeroyi are specific towards S,S-dimethyl-beta-propiothetin. They do not demethylate glycine-betaine [1,2].

History

EC 2.1.1.269 created 2013

Pathway

ec00920

Sulfur metabolism

ec01100

Metabolic pathways

Orthology

K17486

dimethylsulfoniopropionate demethylase

Genes

GAI:	IMCC3135_15030(dmdA)

HOE:	IMCC20628_01219

LABR:

CHH27_18755(dmdA)

LABP:

FJ695_04260

SIL:	SPO1913(dmdA)

SIT:	TM1040_1444

RUA:	D1823_05765

RUT:	FIU92_07260(dmdA)

RCON:

K3740_08065

JAN:

Jann_2379

RDE:

RD1_2288

RLI:	RLO149_c022350

RPON:

G3256_07845

DSH:	Dshi_2320(gcvT1)

PGA:	PGA1_262p01830

OAT:	OAN307_c32590

OAR:	OA238_c20430

OTM:	OSB_12930(dmdA)

OCT:	FTO60_06890

LMD:	METH_10405(dmdA)

LEJ:	ETW24_11110

LAQU:

R2C4_07615

LEV:	ETW23_11065

LCAE:

K3721_09560

RED:	roselon_02762

MALG:

MALG_05026

SULZ:

C1J03_10680(dmdA)

SULI:

C1J05_10880(dmdA)

SULD:

B5M07_09030(dmdA)

SMED:

JNX03_05055

SINL:

DSM14862_01560(dmdA)

SUAL:

KDD17_07030

SDUB:

R1T39_02955

TOM:	BWR18_06790(dmdA)

RMM:	ROSMUCSMR3_03150(dmdA)

ROK:	RAK1035_2045

RID:	RIdsm_03278(dmdA_2)

ROM:	EI983_06395

ROH:	FIU89_12640(dmdA1)

AHT:	ANTHELSMS3_04733

THAA:

CFI11_12685(dmdA)

LALG:

LentiSH36_01118

MARU:

FIU81_11530(dmdA)

RMAI:

MACH21_15250

RMB:	K529_006360(dmdA)

TSCO:

R1T40_04730

PPSO:

QPJ95_16420

BOO:	E2K80_07960

PAED:

G5B38_17915

CACT:

HZ995_14240

GCE:	KYE46_10740

ACRO:

K3J57_07910

AALK:

LGT41_0009710

AMYL:

QBD29_10965

AMAQ:

GO499_10870

PUB:	SAR11_0246

PEG:	E5R92_05090

APC:	HIMB59_00001390

APM:	HIMB5_00000090

APB:	SAR116_0074

SNEA:

NBZ79_04410

» show all

Reference

1 [PMID:9396840]

Authors

Jansen M, Hansen TA

Title

Tetrahydrofolate serves as a methyl acceptor in the demethylation of dimethylsulfoniopropionate in cell extracts of sulfate-reducing bacteria.

Journal

Arch Microbiol 169:84-7 (1998)
DOI:10.1007/s002030050545

Reference

2 [PMID:18849431]

Authors

Reisch CR, Moran MA, Whitman WB

Title

Dimethylsulfoniopropionate-dependent demethylase (DmdA) from Pelagibacter ubique and Silicibacter pomeroyi.

Journal

J Bacteriol 190:8018-24 (2008)
DOI:10.1128/JB.00770-08

Sequence

[pub:SAR11_0246] [sil:SPO1913]

Reference

3 [PMID:22162093]

Authors

Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN

Title

Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism Pelagabacter ubique.

Journal

Protein Sci 21:289-98 (2012)
DOI:10.1002/pro.2015

Sequence

[pub:SAR11_0246]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.269

IUBMB Enzyme Nomenclature:

2.1.1.269

ExPASy - ENZYME nomenclature database:

2.1.1.269

BRENDA, the Enzyme Database:

2.1.1.269

DBGET integrated database retrieval system