KEGG ENZYME: 2.1.1.28

ENZYME: 2.1.1.28

Entry

EC 2.1.1.28                 Enzyme

Name

phenylethanolamine N-methyltransferase;
noradrenaline N-methyltransferase;
noradrenalin N-methyltransferase;
norepinephrine methyltransferase;
norepinephrine N-methyltransferase;
phenethanolamine methyltransferase;
phenethanolamine N-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine [RN:R04033]

Reaction(KEGG)

R04033;
(other) R02533

Substrate

S-adenosyl-L-methionine [CPD:C00019];
phenylethanolamine [CPD:C02735]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
N-methylphenylethanolamine [CPD:C03711]

Comment

Acts on various phenylethanolamines; converts noradrenaline into adrenaline.

History

EC 2.1.1.28 created 1972

Pathway

ec00350

Tyrosine metabolism

ec01100

Metabolic pathways

Orthology

K00553

phenylethanolamine N-methyltransferase

Genes

HSA:	5409(PNMT)

PTR:	454634(PNMT)

PPS:	100978896(PNMT)

GGO:	101140487(PNMT)

PON:	100450669(PNMT)

NLE:	100603046(PNMT)

HMH:	116474143(PNMT)

MCC:	697444(PNMT)

MCF:	102144850(PNMT)

MTHB:

126938523

MNI:	105472245(PNMT)

CSAB:

103243536(PNMT)

CATY:

105579551(PNMT)

PANU:

101008479(PNMT)

TGE:	112609871(PNMT)

MLEU:

105553094(PNMT)

RRO:	104674852(PNMT)

RBB:	108527783(PNMT)

TFN:	117067090(PNMT)

PTEH:

111537273(PNMT)

CANG:

105503122(PNMT)

CJC:	100405480(PNMT)

SBQ:	101032723(PNMT)

CIMI:

108281624(PNMT)

CSYR:

103275270(PNMT)

MMUR:

105872103(PNMT)

LCAT:

123620835(PNMT)

PCOQ:

105824370(PNMT)

OGA:	100954802(PNMT)

MMU:	18948(Pnmt)

MCAL:

110306272(Pnmt)

MPAH:

110332744(Pnmt)

RNO:	24661(Pnmt)

MCOC:

116078086(Pnmt)

ANU:	117709922(Pnmt)

MUN:	110562946(Pnmt)

CGE:	100768410(Pnmt)

MAUA:

101842703(Pnmt)

PROB:

127221416(Pnmt)

PLEU:

114706966(Pnmt)

MORG:

121442328 121456155

MFOT:

126510548

AAMP:

119811412(Pnmt)

NGI:	103743823(Pnmt)

HGL:	101706187(Pnmt)

CPOC:

100727379(Pnmt)

CCAN:

109694115(Pnmt)

DORD:

106002191(Pnmt)

DSP:	122100311(Pnmt)

PLOP:

125365357(Pnmt)

NCAR:

124980951

MMMA:

107160002(Pnmt)

OCU:

100355890

OPI:	101529625(PNMT)

TUP:	102501155(PNMT)

GVR:	103605212(PNMT)

CFA:	491023(PNMT)

CLUD:

112655419(PNMT)

VVP:	112918118(PNMT)

VLG:	121473337(PNMT)

NPO:	129511313(PNMT)

AML:	100480535(PNMT)

UMR:	103662175(PNMT)

UAH:	113265179(PNMT)

UAR:	123779538(PNMT)

ELK:

111151828

LLV:

125086857

MPUF:

101694546(PNMT)

MNP:	132003511(PNMT)

MLK:	131815693(PNMT)

NVS:	122907627(PNMT)

ORO:	101365469(PNMT)

EJU:	114198479(PNMT)

ZCA:	113907960(PNMT)

MLX:	118025065(PNMT)

NSU:	110593247(PNMT)

LWW:	102734219(PNMT)

FCA:	101101350(PNMT)

PYU:	121044912(PNMT)

PBG:	122485477(PNMT)

PVIV:

125158494(PNMT)

LRUF:

124513489

PTG:	102961408(PNMT)

PPAD:

109247421(PNMT)

PUC:

125926478

AJU:

106980500

HHV:	120229107(PNMT)

BTA:	281413(PNMT)

BOM:	102267416(PNMT)

BIU:	109574122(PNMT)

BBUB:

102410415(PNMT)

BBIS:

104990534(PNMT)

CHX:	102175988(PNMT)

OAS:	101103826(PNMT)

BTAX:

128064540(PNMT)

ODA:	120867218(PNMT)

MBEZ:

129544353(PNMT)

SSC:	100144479(PNMT)

CFR:	102520076(PNMT)

CBAI:

105073263(PNMT)

CDK:	105099042(PNMT)

VPC:	102539133(PNMT)

BACU:

103001658(PNMT)

BMUS:

118886832(PNMT)

LVE:	103074918(PNMT)

OOR:	101283122(PNMT)

DLE:	111166487(PNMT)

PCAD:

102991209(PNMT)

PSIU:

116745885(PNMT)

NASI:

112399915(PNMT)

ECB:	100033859(PNMT)

EPZ:	103550153(PNMT)

EAI:	106826394(PNMT)

MYB:	102249392(PNMT)

MYD:	102758984(PNMT)

MMYO:

118672411(PNMT)

MLF:	102427470(PNMT)

PKL:	118702176(PNMT)

EFUS:

103297141(PNMT)

MNA:	107528967(PNMT)

DRO:	112316421(PNMT)

SHON:

118978084(PNMT)

AJM:	119045744(PNMT)

PDIC:

114503842(PNMT)

PHAS:

123817477(PNMT)

MMF:	118634656(PNMT)

PPAM:

129087053(PNMT)

HAI:	109380659(PNMT)

RFQ:	117012975(PNMT)

PALE:

102883108 102885798

PGIG:

120611193(PNMT)

PVP:	105307496(PNMT)

RAY:	107520713(PNMT)

MJV:	108390001(PNMT)

TOD:	119231999(PNMT)

SARA:

101540554(PNMT)

LAV:	100655935(PNMT)

TMU:

101355696

ETF:	101640186(PNMT)

DNM:	101414088(PNMT)

MDO:	100017260(PNMT)

GAS:	123245478(PNMT)

SHR:	100928301(PNMT)

AFZ:

127560215

PCW:	110215827(PNMT)

OAA:	100079586(PNMT)

GGA:	100858738(PNMT)

PCOC:

116233706(PNMT)

MGP:	104914599(PNMT) 104916482

CJO:	107325268(PNMT)

TPAI:

128089054(PNMT)

NMEL:

110388710(PNMT)

APLA:

113840035(PNMT)

CATA:

118261284(PNMT)

AFUL:

116498579(PNMT)

TGU:	100228437(PNMT)

LSR:	110471932(PNMT)

PMOA:

120496644(PNMT)

OTC:	121347647(PNMT)

PRUF:

121354027

GFR:	102031976(PNMT)

OMA:	130264176(PNMT)

PHI:	102110801(PNMT)

CCAE:

111944131

CCW:	120411314(PNMT)

ETL:	114071804(PNMT)

SVG:	106858600(PNMT)

HRT:	120763816(PNMT)

NNI:	104017695(PNMT)

TALA:

116962923(PNMT)

ACHC:

115344854(PNMT)

HLE:	104842900(PNMT)

AGEN:

126038632

SHAB:

115617688(PNMT)

RTD:	128919300(PNMT)

CUCA:

104067976(PNMT)

AROW:

112969536(PNMT)

NPD:	112960207(PNMT)

DNE:	112978741(PNMT)

ASN:	102370069(PNMT)

AMJ:	102558831(PNMT)

CPOO:

109320279(PNMT)

CMY:	102946470(PNMT)

CCAY:

125626760(PNMT)

DCC:	119849060(PNMT)

CPIC:

101947293(PNMT)

TST:	117869275(PNMT)

CABI:

116831383(PNMT)

MRV:	120392099(PNMT)

ACS:	100565710(pnmt)

ASAO:

132778281(PNMT)

PVT:	110082064(PNMT)

SUND:

121934184(PNMT)

PBI:	103057808(PNMT)

PMUR:

107303015(PNMT)

CTIG:

120315092(PNMT)

TSR:	106538850(PNMT)

PGUT:

117664671(PNMT)

APRI:

131197796(PNMT)

PTEX:

113447382(PNMT)

NSS:	113420010(PNMT)

VKO:	123031789(PNMT)

PMUA:

114582804(PNMT)

PRAF:

128400681(PNMT)

ZVI:	118095231(PNMT)

HCG:	128330746(PNMT)

GJA:	107114737(PNMT)

STOW:

125445179(PNMT)

EMC:	129340553(PNMT)

XLA:	108700775(pnmt.L) 108702360(pnmt.S)

XTR:	100492236(pnmt)

NPR:	108792760(PNMT)

RTEM:

120918714(PNMT)

BBUF:

121005290(PNMT)

BGAR:

122942578(PNMT)

MUO:	115459237 115481886(PNMT)

GSH:	117347095(PNMT)

DRE:

100332609

SRX:	107716495(pnmt)

SANH:

107676565

SGH:

107571312

CCAR:

109092887

CAUA:

113097040(pnmt)

CGIB:

127968979

PTET:

122355392 122355418

LROH:

127173937

OMC:

131551149

PPRM:

120488708

RKG:

130087361

MAMB:

125251887

CIDE:

127523965

MASI:

127427224

TROS:

130568790 130569553

TDW:

130438768

MANU:

129420695

IPU:

108273631

PHYP:

113535195(pnmt)

SMEO:

124400866

TFD:

113662506

TVC:

132857913

AMEX:

103022410

CMAO:

118808907

EEE:	113576882(pnmt)

CHAR:

105896459

TRU:	101068284(pnmt)

TFS:

130527702

LCO:	104922126 104933416

NCC:	104943468(pnmt) 104960380

TBEN:

117473456

CGOB:

115024816(pnmt)

PGEO:

117464483

GACU:

117543104

EMAC:

134870630

ELY:

117247628

EFO:

125880726

PLEP:

121959377

SLUC:

116048219 116050010 116050892 116055161 116055163 116061328 116061329

ECRA:

117936956 117958272

ESP:	116671185 116684757 116702995

PFLV:

114547626(pnmt) 114568862 114569203 114569205 114569206 114570235 114570242

GAT:

120819704

PPUG:

119213098

AFB:

129091703

CLUM:

117748978

PSWI:

130203471

MSAM:

119916634

SCHU:

122867745 122867746

CUD:

121528851

ALAT:

119010219

MZE:	101478707(pnmt)

ONL:	100704948(pnmt)

OAU:

116327519

OLA:	101172030(pnmt)

OML:

112154569

CSAI:

133419292

XMA:	102217979(pnmt)

XCO:	114151774(pnmt)

XHE:	116726809(pnmt)

PRET:

103481424(pnmt)

PFOR:

103142266(pnmt)

PLAI:

106949709(pnmt)

PMEI:

106920906(pnmt)

GAF:

122822990

PPRL:

129368118

CVG:	107089993(pnmt)

CTUL:

119774906

GMU:

124874672

NFU:	107387578(pnmt)

KMR:

108247644

ALIM:

106516992(pnmt)

NWH:

119423675

AOCE:

111566735(pnmt)

MCEP:

125022515

CSEM:

103381482(pnmt)

POV:	109626801(pnmt)

SSEN:

122759235

HHIP:

117753434

HSP:

118100870

SMAU:

118287552

LCF:

108901731

SDU:	111220132(pnmt)

SLAL:

111657100(pnmt)

XGL:

120794598

HCQ:	109513412(pnmt)

SSCV:

125991200

SBIA:

133495800

PEE:

133418069

PTAO:

133469429

BPEC:

110154403(pnmt)

MALB:

109962872(pnmt)

BSPL:

114845670

SJO:

128381642

SASA:

106579371(pnmt)

STRU:

115161153(pnmt)

OTW:

112223306

OMY:

110491677

OGO:

124047743

ONE:	115106201(pnmt)

OKI:	109865886(pnmt)

OKE:

118369033

SALP:

111977642(pnmt)

SNH:

120045776

CCLU:

121582224

ELS:	105006836(pnmt)

SFM:	108919132(pnmt)

PKI:	111856096(pnmt)

AANG:

118221305

LOC:	102687297(pnmt)

PSPA:

121324706

ARUT:

117435192

PSEX:

120522527

LCM:	102365914(PNMT)

CMK:

103183857

CPLA:

122539657

HOC:

132830960

LERI:

129710061

BFO:	118404812 118408157 118411785 118425090 118427144 118428020

BBEL:

109485686 109485819

DMK:	116915613 116920610 116924061

PTRU:

123513674

HAZT:

108680444

LSM:

121121405

TCF:

131880982

PPOI:

119090506

MYI:	110456502 110459317 110459319

BLEP:

AL038_03540

» show all

Reference

1 [PMID:13863458]

Authors

AXELROD J.

Title

Purification and properties of phenylethanolamine-N-methyl transferase.

Journal

J Biol Chem 237:1657-60 (1962)

Reference

2 [PMID:5412063]

Authors

Connett RJ, Kirshner N.

Title

Purification and properties of bovine phenylethanolamine N-methyltransferase.

Journal

J Biol Chem 245:329-34 (1970)

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.28

IUBMB Enzyme Nomenclature:

2.1.1.28

ExPASy - ENZYME nomenclature database:

2.1.1.28

BRENDA, the Enzyme Database:

2.1.1.28

CAS:

9037-68-7

DBGET integrated database retrieval system