| Entry |
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| Name |
8-demethylnovobiocic acid C8-methyltransferase;
NovO
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 8-demethylnovobiocic acid = S-adenosyl-L-homocysteine + novobiocic acid [RN: R10454]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
8-demethylnovobiocic acid [CPD: C20629]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
novobiocic acid [CPD: C12474]
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| Comment |
The enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin.
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| History |
EC 2.1.1.284 created 2013
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K12705 | 8-demethylnovobiocic acid C8-methyltransferase |
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| Reference |
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| Authors |
Pacholec M, Tao J, Walsh CT |
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| Title |
CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.284 |
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