Entry |
|
Name |
6-hydroxytryprostatin B O-methyltransferase;
ftmD (gene name)
|
Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
Sysname |
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
|
Reaction(IUBMB) |
S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A [RN: R10588]
|
Reaction(KEGG) |
|
Substrate |
S-adenosyl-L-methionine [CPD: C00019];
6-hydroxytryprostatin B [CPD: C20513]
|
Product |
S-adenosyl-L-homocysteine [CPD: C00021];
tryprostatin A [CPD: C20607]
|
Comment |
Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
|
History |
EC 2.1.1.293 created 2013
|
Pathway |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K18280 | 6-hydroxytryprostatin B O-methyltransferase |
|
Genes |
|
Reference |
|
Authors |
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H |
Title |
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.1.1.293 |
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