KEGG ENZYME: 2.1.1.295

ENZYME: 2.1.1.295

Entry

EC 2.1.1.295                Enzyme

Name

2-methyl-6-phytyl-1,4-hydroquinone methyltransferase;
VTE3 (gene name);
2-methyl-6-solanyl-1,4-hydroquinone methyltransferase;
MPBQ/MSBQ methyltransferase;
MPBQ/MSBQ MT

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:2-methyl-6-phytyl-1,4-benzoquinol C-3-methyltransferase

Reaction(IUBMB)

(1) S-adenosyl-L-methionine + 2-methyl-6-phytylbenzene-1,4-diol = S-adenosyl-L-homocysteine + 2,3-dimethyl-6-phytylbenzene-1,4-diol [RN:R07501];
(2) S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol = S-adenosyl-L-homocysteine + plastoquinol [RN:R10709];
(3) S-adenosyl-L-methionine + 6-geranylgeranyl-2-methylbenzene-1,4-diol = S-adenosyl-L-homocysteine + 6-geranylgeranyl-2,3-dimethylbenzene-1,4-diol [RN:R10710]

Reaction(KEGG)

R07501 R10709 R10710

Substrate

S-adenosyl-L-methionine [CPD:C00019];
2-methyl-6-phytylbenzene-1,4-diol [CPD:C15882];
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol [CPD:C17570];
6-geranylgeranyl-2-methylbenzene-1,4-diol [CPD:C20737]

Product

plastoquinol [CPD:C16695]

Comment

Involved in the biosynthesis of plastoquinol, as well as vitamin E (tocopherols and tocotrienols).

History

EC 2.1.1.295 created 2014

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12502

MPBQ/MSBQ methyltransferase

K18534

MPBQ/MSBQ methyltransferase

Genes

ATH:	AT3G63410(APG1)

ALY:

9312789

CRB:

17887229

CSAT:

104699535 104699536 104748980 104788679 104788680

EUS:	EUTSA_v10006087mg

BRP:

103830388

BNA:	106353332 106410579

BOE:

106300824

RSZ:

108818362

THJ:	104801966 104823034

CPAP:

110823242

CIT:	102614553 102630396

CIC:	CICLE_v10005361mg CICLE_v10021032mg

PVY:	116131110 116145854 116146149

MINC:

123211534 123212063

TCC:	18603086 18613261

GRA:	105777662 105790679 105796688 105803144

GHI:	107897057 107902204 107914985 107915302 107924420 107924562 107927797 107941613

GAB:	108470117 108474174 108475431 108484494

HSYR:

120133133 120143697 120189169 120204827 120218276

DZI:	111305232 111307356 111314269

EGR:

104427271

GMX:	100783986 100788766 100806615

GSJ:	114371939 114377441 114389734

PVU:	PHAVU_007G175500g PHAVU_007G279000g

VRA:	106772053 106772119

VAR:	108324031 108326079

VUN:	114190003 114192009

VUM:	124838164 124844649

CCAJ:

109798185 109813953

APRC:

113871244 113873393 113873781

MTR:	11429739 25484476

TPRA:

123911864 123924323

CAM:	101490902 101491654

PSAT:

127091659 127095675

VVO:	131644268 131644440

LJA:	Lj5g3v1014830.1(Lj5g3v1014830.1) Lj5g3v1208090.1(Lj5g3v1208090.1)

ADU:

107473483

AIP:

107624907

AHF:	112726944 112737364

LANG:

109336117 109346662

PCIN:

129307123 129319980

QSA:	O6P43_006973 O6P43_010580 O6P43_021511

FVE:	101303502 101310277

RCN:	112168757 112196927 112200119

PPER:

18767488 18790101

PMUM:

103323966 103334183

PAVI:

110760969 110763422

PDUL:

117638272 117638826

MDM:	103413350 103419087 103424079 103425704

MSYL:

126589576 126597382 126608335 126617207

PXB:	103929764 103960081 103964755

ZJU:	107413125 107425921

MNT:	21395748 21396522

CSAV:

115717636 115722111

CSV:

101218864

CMO:

103491265

BHJ:

120077947

MCHA:

111015269

CMAX:

111466918 111491019

CMOS:

111437409 111463939

CPEP:

111795869 111811588

RCU:	8276696 8280209

JCU:	105632060 105649922

HBR:	110631738 110636214 110645645

MESC:

110602226 110611451 110615165

POP:	7473437 7476869 7480667

PEU:	105126799 105127667 105131376

PALZ:

118049320 118056626 118061641

JRE:	108997758 109005098 109018791

CILL:

122300743 122316801 122318706

CAVE:

132170894 132177490

QSU:	111999076 112034239

QLO:	115971346 115994415

TWL:	119991203 120007114

VVI:	100240861 100266496

VRI:	117914735 117918894

SLY:	101255662 101267644

SPEN:

107014330 107031218

SOT:	102592709 102604412

SSTN:

125857861 125871311

SDUL:

129882789 129896253

CANN:

107863813 107868474

LBB:	132610759 132616528

NTA:	107760985 107773365 107793127 107814278

NSY:	104210164 104242982

NTO:	104092670 104096486

NAU:	109209900 109219112

INI:	109173882 109176188

ITR:	116002492 116003478

SIND:

105163320

OEU:

111375743

EGT:

105952873

SSPL:

121792938 121802014

SMIL:

131016348

SHIS:

125223361

APAN:

127259157 127266573

HAN:	110865372 110937001

ECAD:

122581366 122590943

LSV:	111882798 111882799 111890210 111897498

CCAV:

112506818 112512534

DCR:	108206732 108223925 108223932

CSIN:

114266558 114273086 114292680 114304669 114317890

RVL:	131313665 131322104 131324225

AEW:

130750913

BVG:

104894575

SOE:

110783632

CQI:	110728964 110734434

ATRI:

130798551 130800249

MOF:	131151818 131156511

NNU:	104612757 104613253

MING:

122059318 122069172 122071571 122073267 122083763 122092451

TSS:	122644257 122671792 122671811 122671822 122671833

PSOM:

113318712 113342468 113347188 113350010

OSA:	107277102 4352791

DOSA:

Os07t0179300-00(Os07g0179300) Os12t0615400-01(Os12g0615400)

OBR:

102717119

OGL:	127758026 127778984

BDI:	100831760 100837610

ATS:	109753840 109759333 109759692

TDC:	119287160 119294532 119298951 119307247 119321410

TAES:

100415847 123087377 123090555 123095599 123102141 123119319 123127840 123137605 123144936

TUA:	125507739 125513849 125529162

LPER:

127298576 127321998 127341353 127341354

LRD:	124651921 124664641 124664642 124666066 124677325

SBI:	8071468 8071470

ZMA:

100284931

SITA:

101777009

SVS:

117847771

PVIR:

120666941 120684537 120684538 120685323 120686264 120700139

PHAI:

112884253

PDA:

103716169

EGU:

105055609

MUS:

103975699

ZOF:	121979469 122011411 122016112 122018716 122022487 122037908

DCT:

110110033

PEQ:

110024315

AOF:

109833025

MSIN:

131232588

NCOL:

116248949

ATR:

18429566

SMO:	SELMODRAFT_130062 SELMODRAFT_230434

PPP:	112280584 112281506

CRE:	CHLRE_14g624350v5 CHLRE_14g625450v5

VCN:	VOLCADRAFT_105494 VOLCADRAFT_81811

MNG:

MNEG_2018

CSL:	COCSUDRAFT_12124 COCSUDRAFT_58884

CVR:	CHLNCDRAFT_140353 CHLNCDRAFT_37067

APRO:

F751_0698

OLU:	OSTLU_10269 OSTLU_3898

OTA:	OT_ostta02g04440 OT_ostta07g04670

BPG:	Bathy08g00510 Bathy17g02220

MIS:	MICPUN_61308 MICPUN_75700

MPP:	MICPUCDRAFT_34256(JGI:MicpuC2_34256) MICPUCDRAFT_49396(JGI:MicpuC2_49396)

CME:	CYME_CMD011C

GSL:	Gasu_48400

CCP:	CHC_T00009101001

PTI:	PHATR_33530

FCY:	FRACYDRAFT_277748(VTE3)

TPS:	THAPSDRAFT_37444

AAF:	AURANDRAFT_12910

EHX:	EMIHUDRAFT_221641 EMIHUDRAFT_98396

GTT:	GUITHDRAFT_65997 GUITHDRAFT_91786

LEZ:

GLE_2516

LEM:

LEN_2498

PBM:	CL52_05635

CPS:

CPS_3306

CELL:

CBR65_12380

PTX:	ABW99_05420

VAP:	Vapar_5778

MEA:	Mex_1p2414

MEX:

Mext_2411

MZA:	B2G69_19680

META:

Y590_11650

DEQ:	XM25_18770

YTI:	FNA67_00420

LABP:

FJ695_03590

DML:	Dmul_17470

SCAR:

DWB96_02690

NTP:	CRH09_08470

STSI:

A4E84_00975

SCOE:

CP976_04955

NGV:	CDO52_13170

APRE:

CNX65_01070

AMI:

Amir_0228

SESP:

BN6_02660 BN6_22810

BALA:

DSM104299_04547

SYN:

sll0418

SYZ:	MYO_119320

SYY:	SYNGTS_1914(sll0418)

SYT:	SYNGTI_1913(sll0418)

SYS:	SYNPCCN_1912(sll0418)

SYQ:	SYNPCCP_1912(sll0418)

SYJ:	D082_05990(erg6)

SYO:	C7I86_09985

SYC:

syc0927_c

SYU:	M744_13870

SYF:	Synpcc7942_0596

SYD:	Syncc9605_0317

SYE:	Syncc9902_2025

SYG:

sync_0378

SYR:	SynRCC307_2173

SYX:	SynWH7803_0376

CYA:

CYA_0166

CYB:

CYB_0976

SYNK:

KR100_02995

SYNR:

KR49_10590

SYND:

KR52_00850

SYH:	Syncc8109_0322

SYNW:

SynWH8103_02461

SYNC:

CB0101_10165

SYNY:

BM449_08390

DSL:	Dacsa_3100

SYW:

SYNW2141

CGC:	Cyagr_1868

CYI:	CBM981_1908

PMA:

Pro_1661

PMM:

PMM1505

PMT:

PMT_1785

PMN:	PMN2A_1071

PMI:	PMT9312_1597

PMB:	A9601_17081

PMC:	P9515_16851

PMF:	P9303_23681

PMG:	P9301_16961

PMH:	P9215_17731

PMJ:	P9211_16281

PME:	NATL1_19461

PRC:

EW14_1844

PRM:

EW15_2010

CMP:	Cha6605_4756

TVN:	NIES2134_116440

SLW:	BRW62_05420

AMR:

AM1_4828

ACAM:

HRE53_19755

TEL:

tll1726

THN:	NK55_05270(vte3)

THEC:

FFX45_07145

LEN:	LEP3755_04620

LET:	O77CONTIG1_03739(rebM_3)

LBO:	LBWT_48160

LSK:	J5X98_11220 J5X98_25630

HHG:	XM38_051350

PSEU:

Pse7367_2884

THEU:

HPC62_08375

TOG:	HNI00_20105

TSIN:

OXH18_23955

GLP:	Glo7428_4337

CHON:

NIES4102_10550

GDU:	P0S91_01690

GEN:	GM3709_2257 GM3709_617

GEE:	GM3708_3417 GM3708_802

CAN:	Cyan10605_1399

CSN:	Cyast_0466

CYL:	AA637_00340 AA637_13830

SYP:	SYNPCC7002_A2739

SYV:	AWQ23_13640 AWQ23_15555

SYL:	AWQ21_13595

LEP:	Lepto7376_1190

SYNN:

NIES970_25240 NIES970_28030

MAR:	MAE_31670 MAE_59960

MPK:	VL20_1779 VL20_6363

MIQ:	B5D77_02930

MVZ:	myaer102_07060 myaer102_32120

HAO:	PCC7418_0287

ENN:	FRE64_14920

CYU:	UCYN_02180

CYT:

cce_2731

CWA:	CwatDRAFT_4775

CYC:	PCC7424_3824

TER:

Tery_2173

ARP:	NIES39_A07610

OXY:	HCG48_08780

LFS:	HFV01_00315

OAC:	Oscil6304_5103

ONI:	Osc7112_6030

MPRO:

BJP34_30195

PHOR:

JWS08_11250

PYH:	NEA10_13165

MIC:	Mic7113_5784

ANA:

all2121

NON:	NOS3756_36660

NFL:	COO91_01274 COO91_04730

NOE:	CLI64_15980

NED:	HUN01_01475 HUN01_02990 HUN01_03115

AVA:

Ava_1078

ANB:	ANA_C11801(adpE)

ANN:	EH233_21115

HBQ:	QI031_30660

CALO:

Cal7507_0565 Cal7507_4157

CALT:

Cal6303_4397

CALH:

IJ00_04090

CALS:

NIES3974_44440

RIV:	Riv7116_2940

FIS:	FIS3754_43390

NSP:	BMF81_01182

DOU:	BMF77_03807(eryG_2)

DFS:	HGD76_24065

AEE:	IM676_19040

TOQ:	HCG51_02875

NCN:	BZZ01_23585

PLP:	Ple7327_1307

SCS:	Sta7437_4216

STAN:

STA3757_03790

GLT:	GlitD10_1410

GCY:	LQF76_10610

CEO:

ETSB_0305

CER:	RGRSB_0258

CEEC:

P3F56_01375

FMR:	Fuma_01242(rebM)

SUS:

Acid_6131

PCM:	AY601_1224

CBAL:

M667_01525

CBAT:

M666_01530

LACI:

CW733_04680

LNU:	N7U66_09200

WIJ:	BWZ20_11920

OLL:	CW732_07315

FEK:	C1H87_16935

AQA:	D1815_12110

MGEL:

G5B37_12465

FLG:	LV716_11585

SPON:

HME9304_00844

NIO:	NITINOP_0343

NJA:

NSJP_3545

NKF:	Nkreftii_001819

NIF:

W02_05090

TBA:	TERMP_01250

THA:

TAM4_1741

THS:

TES1_1284

TEU:

TEU_11385

TTD:	A3L14_08820

PPAC:

PAP_07330 PAP_07335

MPD:

MCP_0823

MEZ:

Mtc_1963

RCI:

LRC129

HJE:	HacjB3_15446 HacjB3_19178

HSN:	DV733_09600

HLM:	DV707_17885

HRU:	Halru_0646

» show all

Reference

1 [PMID:11821038]

Authors

Shintani DK, Cheng Z, DellaPenna D

Title

The role of 2-methyl-6-phytylbenzoquinone methyltransferase in determining tocopherol composition in Synechocystis sp. PCC6803.

Journal

FEBS Lett 511:1-5 (2002)
DOI:10.1016/S0014-5793(01)03223-9

Sequence

[syn:sll0418]

Reference

2 [PMID:14508009]

Authors

Cheng Z, Sattler S, Maeda H, Sakuragi Y, Bryant DA, DellaPenna D

Title

Highly divergent methyltransferases catalyze a conserved reaction in tocopherol and plastoquinone synthesis in cyanobacteria and photosynthetic eukaryotes.

Journal

Plant Cell 15:2343-56 (2003)
DOI:10.1105/tpc.013656

Sequence

[syn:sll0418] [ath:AT3G63410] [cre:CHLRE_14g624350v5 CHLRE_14g625450v5]

Reference

3 [PMID:14630966]

Authors

Van Eenennaam AL, Lincoln K, Durrett TP, Valentin HE, Shewmaker CK, Thorne GM, Jiang J, Baszis SR, Levering CK, Aasen ED, Hao M, Stein JC, Norris SR, Last RL

Title

Engineering vitamin E content: from Arabidopsis mutant to soy oil.

Journal

Plant Cell 15:3007-19 (2003)
DOI:10.1105/tpc.015875

Sequence

[ath:AT3G63410] [ana:all2121]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.295

IUBMB Enzyme Nomenclature:

2.1.1.295

ExPASy - ENZYME nomenclature database:

2.1.1.295

BRENDA, the Enzyme Database:

2.1.1.295

DBGET integrated database retrieval system