KEGG ENZYME: 2.1.1.299

ENZYME: 2.1.1.299

Entry

EC 2.1.1.299                Enzyme

Name

protein N-terminal monomethyltransferase;
NRMT2 (gene name);
METTL11B (gene name);
N-terminal monomethylase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]

Substrate

S-adenosyl-L-methionine [CPD:C00019];
N-terminal-(A,P,S)PK-[protein]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
N-terminal-N-methyl-N-(A,P,S)PK-[protein]

Comment

This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.

History

EC 2.1.1.299 created 2014

Orthology

K19579

protein N-terminal monomethyltransferase

Genes

HSA:	149281(NTMT2)

PTR:	469577(METTL11B)

PPS:	100987718(METTL11B)

GGO:	101152939(METTL11B)

PON:	100444887 112132363

NLE:	100586787(METTL11B)

HMH:	116472304(NTMT2)

MCC:	705503(METTL11B)

MCF:	102119511(NTMT2)

MTHB:

126950485

MNI:	105493046(METTL11B)

CSAB:

103230610(METTL11B)

CATY:

105600153(METTL11B)

PANU:

101013648(METTL11B)

TGE:	112611070(METTL11B)

MLEU:

105539608(METTL11B)

RRO:	104669430(METTL11B)

RBB:	108527263(METTL11B)

TFN:	117075584(METTL11B)

PTEH:

111539265(METTL11B)

CANG:

105526325(METTL11B)

CJC:	100411855(NTMT2)

SBQ:	101045661(METTL11B)

CIMI:

108308350(METTL11B)

CSYR:

103253493(METTL11B)

MMUR:

105870800(METTL11B)

LCAT:

123634675(NTMT2)

PCOQ:

105821121(METTL11B)

OGA:	100955421(METTL11B)

MMU:	240879(Ntmt2)

MCAL:

110303799(Mettl11b)

MPAH:

110322511(Mettl11b)

RNO:	289167(Ntmt2)

MCOC:

116070827(Mettl11b)

ANU:	117716493(Mettl11b)

MUN:	110549919(Ntmt2)

CGE:	100752444(Mettl11b)

MAUA:

101825921(Mettl11b)

PROB:

127223239(Ntmt2)

PLEU:

114689952(Mettl11b)

MORG:

121454932(Mettl11b)

MFOT:

126511339

AAMP:

119827031(Ntmt2)

NGI:	103727098(Mettl11b)

HGL:	101718425(Mettl11b) 101722032

CPOC:

100718393

CCAN:

109691209(Mettl11b)

DORD:

105985142(Mettl11b)

DSP:	122103707(Ntmt2)

PLOP:

125359531(Ntmt2)

NCAR:

124961130

MMMA:

107147391(Ntmt2)

OCU:	100346292(NTMT2)

OPI:	101522919(METTL11B)

TUP:	102475213(METTL11B)

GVR:	103604863(METTL11B)

CFA:	490351(METTL11B)

CLUD:

112648647(NTMT2)

VVP:	112923452(METTL11B)

VLG:	121501613(NTMT2)

NPO:	129508618(NTMT2)

AML:	100466656(METTL11B)

UMR:	103667791(METTL11B)

UAH:	113262619(METTL11B)

UAR:	123792646(NTMT2)

ELK:

111150612

LLV:

125085727

MPUF:

101678072(METTL11B)

MNP:	132026040(NTMT2)

MLK:	131815049(NTMT2)

NVS:	122918118(NTMT2)

ORO:	101386407(METTL11B)

EJU:	114223976(METTL11B)

ZCA:	113932593(METTL11B)

MLX:	118014492(METTL11B)

NSU:	110574225(NTMT2)

LWW:	102730266(METTL11B)

FCA:	101084764(NTMT2)

PYU:	121014970(METTL11B)

PCOO:

112863215(METTL11B)

PBG:	122476045(NTMT2)

PVIV:

125154943(NTMT2)

LRUF:

124510103

PTG:	102967658(METTL11B)

PPAD:

109252208(METTL11B)

PUC:

125925132

AJU:	106966229(NTMT2)

HHV:	120234157(METTL11B)

BTA:	521303(NTMT2)

BOM:	102274395(METTL11B)

BIU:	109570672(METTL11B)

BBUB:

102415209(NTMT2)

BBIS:

104986239(METTL11B)

CHX:	102172563(METTL11B)

OAS:	101103252(NTMT2)

BTAX:

128061802(NTMT2)

ODA:	120880263(METTL11B)

CCAD:

122452495(NTMT2)

MBEZ:

129551577(NTMT2)

SSC:	100157210(METTL11B)

CFR:	102523187(METTL11B)

CBAI:

105068083(METTL11B)

CDK:	105092751(METTL11B)

VPC:	102530912(METTL11B)

BACU:

103016571(METTL11B)

BMUS:

118906134(METTL11B)

LVE:	103073590(METTL11B)

OOR:	101289399(NTMT2)

DLE:	111167368(METTL11B)

PCAD:

102995569(NTMT2)

PSIU:

116756222(METTL11B)

NASI:

112398068(METTL11B)

ECB:	100059169(METTL11B)

EPZ:	103550805(METTL11B)

EAI:	106833811(NTMT2)

MYB:	102255085(METTL11B)

MYD:	102754821(METTL11B)

MMYO:

118672660(METTL11B)

MLF:	102426834(METTL11B)

PKL:	118721548(METTL11B)

EFUS:

103289949(NTMT2)

MNA:	107543739(METTL11B)

DRO:	112321237(METTL11B)

SHON:

118979242(METTL11B)

AJM:	119065396(METTL11B)

PDIC:

114512146(METTL11B)

PHAS:

123818483(NTMT2)

MMF:	118637911(METTL11B)

PPAM:

129081938(NTMT2)

HAI:	109385450(METTL11B)

RFQ:	117014930(METTL11B)

PALE:

102885906(METTL11B)

PGIG:

120617742(METTL11B)

PVP:	105299808(METTL11B)

RAY:	107512770(METTL11B)

TOD:	119240078(NTMT2)

SARA:

101542862(METTL11B)

LAV:	100661734(METTL11B)

TMU:

101361457

ETF:	101653475(NTMT2)

DNM:	101438615(METTL11B)

MDO:	100019985(METTL11B)

GAS:	123245891(NTMT2)

SHR:	100922386(METTL11B)

AFZ:

127562919

PCW:	110196979(METTL11B)

OAA:	120637992(METTL11B)

GGA:	429066(METTL11B)

PCOC:

116230484(METTL11B)

MGP:	104909323(METTL11B)

CJO:	107317298(METTL11B)

TPAI:

128072297(NTMT2)

LMUT:

125692928(NTMT2)

NMEL:

110402352(METTL11B)

APLA:

101799335(METTL11B)

ACYG:

106041617(NTMT2)

CATA:

118243546(NTMT2)

AFUL:

116492169(METTL11B)

TGU:	100223826(METTL11B)

LSR:	110478926(METTL11B)

SCAN:

103823381(METTL11B)

PMOA:

120512248(METTL11B)

OTC:	121344286(METTL11B)

PRUF:

121359787(METTL11B)

GFR:	102040508(METTL11B)

FAB:	101821734(METTL11B)

OMA:	130256257(NTMT2)

PHI:	102112950(METTL11B)

PMAJ:

107208356(METTL11B)

CCAE:

111932492(METTL11B)

CCW:	104695457(METTL11B)

CBRC:

103612522(METTL11B)

ETL:	114063562(METTL11B)

ZAB:	102064024(METTL11B)

ACHL:

103804535(METTL11B)

SVG:	106852314(METTL11B)

MMEA:

130577414(NTMT2)

HRT:	120756453(NTMT2)

FPG:	101921234(METTL11B)

FCH:	102057343(METTL11B)

CLV:	102084074(METTL11B)

EGZ:	104132065(METTL11B)

NNI:	104010396(METTL11B)

PCRI:

104030079(METTL11B)

PLET:

104625108(METTL11B)

EHS:	104504164(METTL11B)

PCAO:

104045531(METTL11B)

ACUN:

113483115(METTL11B)

TALA:

104356912(NTMT2)

PADL:

103914011(METTL11B)

AFOR:

103893992(METTL11B)

ACHC:

115348986(METTL11B)

HALD:

104317251(METTL11B)

HLE:	104840536(METTL11B)

AGEN:

126042344

GCL:

127019313

CCRI:

104163326(METTL11B)

CSTI:

104557138(METTL11B)

CMAC:

104481188(METTL11B)

MUI:	104536041(METTL11B)

BREG:

104636914(METTL11B)

FGA:	104083643(METTL11B)

GSTE:

104262654(METTL11B)

LDI:	104346658(METTL11B)

MNB:	103775228(METTL11B)

OHA:	104333716(METTL11B)

NNT:	104400233(METTL11B)

SHAB:

115611948(METTL11B)

DPUB:

104301544(METTL11B)

PGUU:

104470659(METTL11B)

ACAR:

104521613(METTL11B)

CPEA:

104390554(METTL11B)

AVIT:

104274284(METTL11B)

CVF:	104293326(METTL11B)

RTD:	128913376(NTMT2)

CUCA:

104058358(METTL11B)

TEO:	104374520(METTL11B)

BRHI:

104491161(METTL11B)

AAM:	106493883(METTL11B)

AROW:

112975093 112976430(METTL11B)

NPD:	112951176(METTL11B)

TGT:	104569975(METTL11B)

DNE:	112997409(METTL11B)

SCAM:

104142684(METTL11B)

ASN:	102370453(METTL11B)

AMJ:	102575018(METTL11B)

CPOO:

109307617(METTL11B)

GGN:	109305389(METTL11B)

PSS:	102446567(METTL11B)

CMY:	102935596(NTMT2)

CCAY:

125641300(NTMT2)

DCC:	119860376(NTMT2)

CPIC:

101944603(NTMT2)

TST:	117882047(METTL11B)

CABI:

116839891(METTL11B)

MRV:	120370099(METTL11B)

ACS:	100555292(mettl11b)

ASAO:

132774332(NTMT2)

PVT:	110090583(METTL11B)

SUND:

121929046(NTMT2)

PBI:	103057111(METTL11B)

PMUA:

114598326(METTL11B)

PRAF:

128415317(NTMT2)

ZVI:	118089068(METTL11B)

HCG:	128323339(NTMT2)

GJA:	107106117(METTL11B)

STOW:

125433149(NTMT2)

EMC:	129331296(NTMT2)

XLA:	108713669(mettl11b.L) 108715745(mettl11b.S)

XTR:	100485318(mettl11b)

NPR:	108793700(METTL11B)

RTEM:

120945511(METTL11B)

BBUF:

120979532(METTL11B)

BGAR:

122944092(NTMT2)

MUO:	115472822(METTL11B)

GSH:	117368351(METTL11B)

DRE:	568419(ntmt2)

SRX:	107726432 107732414

SANH:

107696087 107698316 107698334

SGH:	107553430 107580753 107599113(mettl11b)

CCAR:

109051906 109063849

CAUA:

113062953 113081988 113120854

CGIB:

127938256 127984392

PTET:

122325148(ntmt2)

LROH:

127182582(ntmt2)

OMC:	131526566(ntmt2)

PPRM:

120493776(mettl11b)

RKG:	130103277(ntmt2)

MAMB:

125278213(ntmt2)

CIDE:

127502509

MASI:

127410053 127416146

TROS:

130566152(ntmt2)

TDW:	130434744(ntmt2)

MANU:

129430054(ntmt2)

IPU:	108257661(ntmt2)

IFU:	128601118(ntmt2)

PHYP:

113546860(mettl11b)

SMEO:

124377288(ntmt2)

TFD:	113653671(ntmt2)

TVC:	132842441(ntmt2)

AMEX:

103038020(mettl11b)

CMAO:

118816143(mettl11b)

EEE:	113581064(mettl11b)

CHAR:

105910875(ntmt2)

TRU:	101074892(mettl11b)

TFS:	130528460(ntmt2)

TNG:	GSTEN00010049G001

LCO:	104936067(mettl11b)

NCC:	104952141(mettl11b)

TBEN:

117495804(mettl11b)

CGOB:

115007533(mettl11b)

PGEO:

117445150(mettl11b)

GACU:

117560473(mettl11b)

EMAC:

134870227(ntmt2)

ELY:

117270691

EFO:	125896329(ntmt2)

PLEP:

121941409(ntmt2)

SLUC:

116054900(mettl11b)

ECRA:

117949923(mettl11b)

ESP:	116684597(mettl11b)

PFLV:

114561967(mettl11b)

GAT:	120823532(mettl11b)

PPUG:

119217268(mettl11b)

AFB:	129095130(ntmt2)

CLUM:

117730021(mettl11b)

PSWI:

130193990(ntmt2)

MSAM:

119900215(mettl11b)

SCHU:

122877955(ntmt2)

CUD:	121512671(mettl11b)

ALAT:

119029170(mettl11b)

MZE:	101485145(mettl11b)

ONL:	100712557(mettl11b)

OAU:	116320841(mettl11b)

OLA:	101166618(mettl11b)

OML:	112150173(mettl11b)

CSAI:

133457926(ntmt2)

XMA:	102226777(mettl11b)

XCO:	114141417(mettl11b)

XHE:	116725810(mettl11b)

PRET:

103463194(mettl11b)

PFOR:

103149968(mettl11b)

PLAI:

106952854(mettl11b)

PMEI:

106924167(mettl11b)

GAF:	122838110(ntmt2)

PPRL:

129379359(ntmt2)

CVG:	107095467(mettl11b)

CTUL:

119780675(mettl11b)

GMU:	124873789(ntmt2)

NFU:	107374283(mettl11b)

KMR:	108247575(mettl11b)

ALIM:

106537053(mettl11b)

NWH:	119430468(ntmt2)

AOCE:

111583804(mettl11b)

MCEP:

125008945(ntmt2)

CSEM:

103399314(mettl11b)

POV:	109643291(mettl11b)

SSEN:

122781307(ntmt2)

HHIP:

117760477(mettl11b)

HSP:	118120855(ntmt2)

SMAU:

118317744(ntmt2)

LCF:	108883491(ntmt2)

SDU:	111227492(mettl11b)

SLAL:

111671603(mettl11b)

XGL:	120791225(mettl11b)

HCQ:	109523463(mettl11b)

SBIA:

133504044(ntmt2)

PEE:	133406017(ntmt2)

PTAO:

133480678(ntmt2)

BPEC:

110174554(mettl11b)

MALB:

109965197(mettl11b)

BSPL:

114854760(ntmt2)

SJO:	128362068(ntmt2)

SASA:

106560537(mettl11b)

STRU:

115158758(mettl11b)

OTW:	112251384(ntmt2)

OMY:	110524770(mettl11b)

OGO:	123997997(ntmt2)

ONE:	115108686(mettl11b)

OKI:	109902874(mettl11b)

OKE:	118379856(ntmt2)

SALP:

111975411(mettl11b)

SNH:	120042743(mettl11b)

CCLU:

121534065(ntmt2)

ELS:	105011974(mettl11b)

SFM:	108935366(mettl11b)

PKI:	111840065(mettl11b)

AANG:

118225198(mettl11b)

LOC:	102686624(mettl11b)

PSPA:

121327257 121330592(mettl11b)

ARUT:

117406079 117416568

PSEX:

120514926(mettl11b)

LCM:	102347657(METTL11B)

CMK:	103179979(ntmt2)

RTP:	109927142(ntmt2)

CPLA:

122554448(ntmt2)

HOC:	132818717(ntmt2)

LERI:

129701118(ntmt2)

PMRN:

116944811

LRJ:	133341176 133341631

» show all

Reference

1 [PMID:24090352]

Authors

Petkowski JJ, Bonsignore LA, Tooley JG, Wilkey DW, Merchant ML, Macara IG, Schaner Tooley CE

Title

NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.

Journal

Biochem J 456:453-62 (2013)
DOI:10.1042/BJ20131163

Sequence

[hsa:149281]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.299

IUBMB Enzyme Nomenclature:

2.1.1.299

ExPASy - ENZYME nomenclature database:

2.1.1.299

BRENDA, the Enzyme Database:

2.1.1.299

All links

Gene (503)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (394)   
   KEGG MGENES (60)   
   RefGene (48)   
Protein sequence (29)   
   UniProt (5)   
   SWISS-PROT (4)   
   RefSeq(pep) (9)   
   PDBSTR (11)   
DNA sequence (11)   
   RefSeq(nuc) (11)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   InterPro (2)   
All databases (549)   

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