Entry
Name
3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase;
AziB2
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 3-hydroxy-5-methyl-1-naphthoate = S-adenosyl-L-homocysteine + 3-methoxy-5-methyl-1-naphthoate [RN:
R10962 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
3-hydroxy-5-methyl-1-naphthoate [CPD:
C20805 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
3-methoxy-5-methyl-1-naphthoate [CPD:
C20980 ]
Comment
The enzyme from the bacterium Streptomyces sahachiroi is involved in the biosynthesis of 3-methoxy-5-methyl-1-naphthoate, a component of of the the antitumor antibiotic azinomycin B.
History
EC 2.1.1.302 created 2014
Orthology
K21377 3-hydroxy-5-methyl-1-naphthoate 3-O-methyltransferase
Genes
SALL : SAZ_04130 SAZ_41020
SACG : FDZ84_22140 FDZ84_37520
» show all
Taxonomy
Reference
Authors
Ding W, Deng W, Tang M, Zhang Q, Tang G, Bi Y, Liu W
Title
Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.302