KEGG ENZYME: 2.1.1.305

ENZYME: 2.1.1.305

Entry

EC 2.1.1.305                Enzyme

Name

8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase;
ElmMI

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN:R10956]

Reaction(KEGG)

R10956

Substrate

S-adenosyl-L-methionine [CPD:C00019];
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [CPD:C20974]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20975]

Comment

The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.

History

EC 2.1.1.305 created 2014

Pathway

ec01057

Biosynthesis of type II polyketide products

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K19567

8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase

Reference

1 [PMID:11376004]

Authors

Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA

Title

Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.

Journal

J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200

Sequence

[ag:CAP12606]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.305

IUBMB Enzyme Nomenclature:

2.1.1.305

ExPASy - ENZYME nomenclature database:

2.1.1.305

BRENDA, the Enzyme Database:

2.1.1.305

DBGET integrated database retrieval system