KEGG   ENZYME: 2.1.1.306
Entry
EC 2.1.1.306                Enzyme                                 
Name
8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase;
ElmMII
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN:R10957]
Reaction(KEGG)
R10957
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20975]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20976]
Comment
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
History
EC 2.1.1.306 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19568  8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase
Reference
1  [PMID:11376004]
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200
  Sequence
[ag:CAP12608]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.306
IUBMB Enzyme Nomenclature: 2.1.1.306
ExPASy - ENZYME nomenclature database: 2.1.1.306
BRENDA, the Enzyme Database: 2.1.1.306

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (4)   
   UniProt (3)   
   SWISS-PROT (1)   
Protein domain (2)   
   InterPro (2)   
All databases (22)   

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