Entry Name 27-O-demethylrifamycin SV methyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:27-O-demethylrifamycin-SV 27-O-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + 27-O-demethylrifamycin SV = S-adenosyl-L-homocysteine + rifamycin SV [RN:
R06998 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
27-O-demethylrifamycin SV [CPD:
C14727 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
rifamycin SV [CPD:
C12044 ]
Comment The enzyme, characterized from the bacterium Amycolatopsis mediterranei, is involved in biosynthesis of the antitubercular drug rifamycin B.
History EC 2.1.1.315 created 2015
Pathway ec01110 Biosynthesis of secondary metabolites
Orthology K15467 27-O-demethylrifamycin SV methyltransferase
Genes SGRF : SGFS_005370 SGFS_005510
Taxonomy Reference Authors Xu J, Mahmud T, Floss HG
Title Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.315
