KEGG   ENZYME: 2.1.1.316
Entry
EC 2.1.1.316                Enzyme                                 
Name
mitomycin 6-O-methyltransferase;
MmcR;
mitomycin 7-O-methyltransferase (incorrect);
S-adenosyl-L-methionine:7-demethylmitomycin-A 7-O-methyltransferase (incorrect)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:6-demethylmitomycin-A 6-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + 6-demethylmitomycin A = S-adenosyl-L-homocysteine + mitomycin A [RN:R11191];
(2) S-adenosyl-L-methionine + 6-demethylmitomycin B = S-adenosyl-L-homocysteine + mitomycin B [RN:R11192]
Reaction(KEGG)
R11191 R11192
Substrate
S-adenosyl-L-methionine [CPD:C00019];
6-demethylmitomycin A [CPD:C21163];
6-demethylmitomycin B [CPD:C21164]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
mitomycin A [CPD:C21161];
mitomycin B [CPD:C21162]
Comment
The enzyme, characterized from the bacterium Streptomyces lavendulae, is involved in the biosynthesis of the quinone-containing antibiotics mitomycin A and mitomycin B.
History
EC 2.1.1.316 created 2015
Orthology
K21427  mitomycin 6-O-methyltransferase
Reference
1  [PMID:17461583]
  Authors
Gruschow S, Chang LC, Mao Y, Sherman DH
  Title
Hydroxyquinone O-methylation in mitomycin biosynthesis.
  Journal
J Am Chem Soc 129:6470-6 (2007)
DOI:10.1021/ja0700193
  Sequence
[ag:AAD32742]
Reference
2  [PMID:21538548]
  Authors
Singh S, Chang A, Goff RD, Bingman CA, Gruschow S, Sherman DH, Phillips GN Jr, Thorson JS
  Title
Structural characterization of the mitomycin 7-O-methyltransferase.
  Journal
Proteins 79:2181-8 (2011)
DOI:10.1002/prot.23040
  Sequence
[ag:AAD32742]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.316
IUBMB Enzyme Nomenclature: 2.1.1.316
ExPASy - ENZYME nomenclature database: 2.1.1.316
BRENDA, the Enzyme Database: 2.1.1.316

  All links  
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (47)   
   UniProt (46)   
   SWISS-PROT (1)   
DNA sequence (57)   
   GenBank (29)   
   EMBL (28)   
Protein domain (5)   
   InterPro (5)   
All databases (121)   

Download RDF
DBGET integrated database retrieval system