KEGG ENZYME: 2.1.1.317

ENZYME: 2.1.1.317

Entry

EC 2.1.1.317                Enzyme

Name

sphingolipid C9-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:(4E,8E)-sphinga-4,8-dienine ceramide C-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + a (4E,8E)-sphinga-4,8-dienine ceramide = S-adenosyl-L-homocysteine + a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide [RN:R11193]

Reaction(KEGG)

R11193

Substrate

S-adenosyl-L-methionine [CPD:C00019];
(4E,8E)-sphinga-4,8-dienine ceramide [CPD:C21022]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide [CPD:C21165]

Comment

The enzyme, characterized from the fungi Komagataella pastoris and Fusarium graminearum, acts only on ceramides and has no activity with free sphingoid bases or glucosylceramides.

History

EC 2.1.1.317 created 2015

Orthology

K20238

sphingolipid C9-methyltransferase

Genes

NVE:

5510658

EPA:

110236733

ATEN:

116295686

ADF:

107340147

AMIL:

114962239

PDAM:

113665883

SPIS:

111341672

DGT:

114521708

XEN:

124434262

HMG:

100198707

HSY:

130628742

AGO:	AGOS_AFR735W

ERC:

Ecym_1018

KLA:	KLLA0_C00715g

KMX:	KLMA_10030

LTH:	KLTH0F00682g

PPA:	PAS_chr4_0465

DHA:	DEHA2E13552g

PIC:	PICST_81203

PGU:	PGUG_03326

SPAA:

SPAPADRAFT_61519

LEL:	PVL30_000483(MTS1)

CAL:	CAALFM_C109680WA(MTS1)

CTP:	CTRG_03390

COT:	CORT_0A03910

CDU:	CD36_09120

CTEN:

CANTEDRAFT_115288

YLI:	YALI0C21494g

CLU:	CLUG_01276

CLUS:

A9F13_06g00770

CAUR:

CJI96_0000755

SLB:	AWJ20_1451

PKZ:	C5L36_0C10030

BNN:	FOA43_003443

BBRX:

BRETT_004294

OPA:	HPODL_02936

NCR:

NCU07859

NTE:	NEUTE1DRAFT62280(NEUTE1DRAFT_62280)

SMP:	SMAC_02133

PAN:	PODANSg5532

PBEL:

QC761_711260(MT2)

PPSD:

QC762_711260(MT2)

PPSP:

QC763_711260(MT2)

PPSA:

QC764_711260(MT2)

TTT:	THITE_2120192

MTM:	MYCTH_2303482

CTHR:

CTHT_0071450

MGR:

MGG_14886

PPEI:

PpBr36_06551

PGRI:

PgNI_00636

TMN:	UCRPA7_1693 UCRPA7_8532

SSCK:

SPSK_03213

FGR:	FGSG_03951 FGSG_05593

FPU:	FPSE_02369 FPSE_05323 FPSE_06183

FPOA:

FPOAC1_006374(MT1) FPOAC1_008017(MT2)

FVN:	FVRRES_06983 FVRRES_08578

FVR:	FVEG_06896 FVEG_10123

FOX:	FOXG_09295 FOXG_11716

NHE:	NECHADRAFT_47156 NECHADRAFT_61548

FFC:	NCS54_00767400 NCS54_01031300

FKR:	NCS57_00807800 NCS57_01024900

FMU:	J7337_009553(MT2) J7337_011388(MT1)

TRE:	TRIREDRAFT_80509

TRR:	M419DRAFT_102296

MAW:	MAC_02943 MAC_09633

MAJ:	MAA_03402 MAA_07734

PCHM:

VFPPC_04272 VFPPC_05313

CMT:

CCM_02837

AMUS:

LMH87_007125

PLJ:	VFPFJ_01351 VFPFJ_10457

PTKZ:

JDV02_007330(MT2) JDV02_008170(MT1)

VAL:	VDBG_05490

VDA:	VDAG_05956

CFJ:	CFIO01_07812 CFIO01_10282

CLUP:

CLUP02_18162

CHIG:

CH63R_13624

SAPO:

SAPIO_CDS9162

ELA:	UCREL1_4508

PFY:	PFICI_11474 PFICI_11535

SSL:	SS1G_05986

BFU:	BCIN_05g00940

MBE:

MBM_07835

PSCO:

LY89DRAFT_691551

ANI:	ANIA_05688 ANIA_07375

AFM:	AFUA_7G04190

ACT:	ACLA_005890

NFI:	NFIA_025160

AOR:	AO090005000104 AO090103000119

ANG:	An02g04530 An13g00740

AFV:	AFLA_002883 AFLA_013401

ALUC:

AKAW2_20134S(MT2) AKAW2_21236A(MT1)

ACHE:

ACHE_40205S(MT2) ACHE_50093S(MT1)

APUU:

APUU_20119S(MT1) APUU_21650S APUU_30850S APUU_41066S(MT2)

PCS:	N7525_005297 N7525_006935

PDP:	PDIP_82450

POU:	POX_c04296

TMF:	EYB26_005550

TRG:	TRUGW13939_00984 TRUGW13939_09612

CIM:	CIMG_07553

CPW:	CPC735_043780

URE:	UREG_07726

PBN:	PADG_08618

ABE:

ARB_02437

TVE:

TRV_06510

AJE:	HCAG_06377

BGH:	BDBG_08008

PNO:	SNOG_03511

PTE:

PTT_17218

BZE:	COCCADRAFT_90884

BSC:	COCSADRAFT_38748

BOR:	COCMIDRAFT_37490

AALT:

CC77DRAFT_861258

ARAB:

EKO05_0008279

ZTR:	MYCGRDRAFT_100674

PFJ:	MYCFIDRAFT_78053

FFU:	CLAFUR5_04970

CBET:

CB0940_11336

BCOM:

BAUCODRAFT_79835

NPA:	UCRNP2_3944

TML:	GSTUM_00009583001

CNE:

CNC07040

CNB:

CNBC0150

CNG:	CNAG_01475

CGI:	CGB_C0170C

CDEU:

CNBG_3953

TMS:	TREMEDRAFT_69739

TASA:

A1Q1_07509

CCAC:

CcaHIS019_0201220(CcaverHIS019_0201220)

TVS:	TRAVEDRAFT_64761

DSQ:	DICSQDRAFT_183486

PCO:	PHACADRAFT_147483

SHS:	STEHIDRAFT_61773

HIR:	HETIRDRAFT_67724

PSQ:	PUNSTDRAFT_145949

ADL:	AURDEDRAFT_117380

FME:	FOMMEDRAFT_146710

GTR:	GLOTRDRAFT_81225

RSX:	RhiXN_06096

LBC:	LACBIDRAFT_295662

CCI:	CC1G_02451

ABP:	AGABI1DRAFT115213(AGABI1DRAFT_115213)

ABV:	AGABI2DRAFT195342(AGABI2DRAFT_195342)

PCUB:

JR316_0011474

MRR:	Moror_3037

E1B28_005900

SCM:	SCHCO_02641924(SCHCODRAFT_02641924)

CPUT:

CONPUDRAFT_131566 CONPUDRAFT_57179

SLA:	SERLADRAFT_471119(cfs5)

WSE:	WALSEDRAFT_33053

WIC:	J056_000732

UMA:	UMAG_01070

PFP:	PFL1_06855

SGRA:

EX895_006118

MGL:

MGL_1826

MRT:

MRET_1986

MSYM:

MSY001_0947

PGR:	PGTG_13395

PTRC:

PtA15_18A159

PSTR:

Pst134EA_026816 Pst134EA_031675

MLR:	MELLADRAFT_53990

SMIN:

v1.2.029480.t1(symbB.v1.2.029480.t1)

EHX:	EMIHUDRAFT_365614 EMIHUDRAFT_468817

GTT:	GUITHDRAFT_97996

SUR:	STAUR_2907

AGE:	AA314_05679

AVM:	JQX13_43000

CFUS:

CYFUS_005416

LLU:	AKJ09_05784 AKJ09_07416 AKJ09_08951

TPX:	Turpa_0943

» show all

Reference

1 [PMID:16339149]

Authors

Ternes P, Sperling P, Albrecht S, Franke S, Cregg JM, Warnecke D, Heinz E

Title

Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling.

Journal

J Biol Chem 281:5582-92 (2006)
DOI:10.1074/jbc.M512864200

Sequence

[ppa:PAS_chr4_0465]

Reference

2 [PMID:19028992]

Authors

Ramamoorthy V, Cahoon EB, Thokala M, Kaur J, Li J, Shah DM

Title

Sphingolipid C-9 methyltransferases are important for growth and virulence but not for sensitivity to antifungal plant defensins in Fusarium graminearum.

Journal

Eukaryot Cell 8:217-29 (2009)
DOI:10.1128/EC.00255-08

Sequence

[fgr:FGSG_03951 FGSG_05593]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.317

IUBMB Enzyme Nomenclature:

2.1.1.317

ExPASy - ENZYME nomenclature database:

2.1.1.317

BRENDA, the Enzyme Database:

2.1.1.317

DBGET integrated database retrieval system