KEGG   ENZYME: 2.1.1.318
Entry
EC 2.1.1.318                Enzyme                                 
Name
[trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + [trehalose-6-phosphate synthase]-L-cysteine = S-adenosyl-L-homocysteine + [trehalose-6-phosphate synthase]-S-methyl-L-cysteine
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[trehalose-6-phosphate synthase]-L-cysteine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[trehalose-6-phosphate synthase]-S-methyl-L-cysteine
Comment
The enzyme, characterized from the yeast Saccharomyces cerevisiae, enhances the activity of EC 2.4.1.15, trehalose-6-phosphate synthase, resulting in elevating the levels of trehalose in the cell and contributing to stationary phase survival. In vitro the enzyme performs S-methylation of L-cysteine residues of various protein substrates.
History
EC 2.1.1.318 created 2015
Orthology
K21426  [trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase
Reference
1  [PMID:24412193]
  Authors
Sengupta S, Banerjee S, Lahiri S, Dutta T, Dhar TK, Ghosh AK
  Title
Purification, characterization, sequencing and molecular cloning of a novel cysteine methyltransferase that regulates trehalose-6-phosphate synthase from Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1840:1861-71 (2014)
DOI:10.1016/j.bbagen.2014.01.005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.318
IUBMB Enzyme Nomenclature: 2.1.1.318
ExPASy - ENZYME nomenclature database: 2.1.1.318
BRENDA, the Enzyme Database: 2.1.1.318

DBGET integrated database retrieval system