KEGG   ENZYME: 2.1.1.322
Entry
EC 2.1.1.322                Enzyme                                 
Name
type IV protein arginine methyltransferase;
RMT2 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine [RN:R11221]
Reaction(KEGG)
R11221
Substrate
S-adenosyl-L-methionine [CPD:C00019];
[protein]-L-arginine [CPD:C00613]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
[protein]-N5-methyl-L-arginine [CPD:C21190]
Comment
This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. cf. EC 2.1.1.319, type I protein arginine methyltransferase, EC 2.1.1.320, type II protein arginine methyltransferase, and EC 2.1.1.321, type III protein arginine methyltransferase.
History
EC 2.1.1.322 created 2015
Orthology
K18477  type IV protein arginine methyltransferase
Genes
SMM: Smp_024380
OVI: T265_13792
EGL: EGR_07793
ATH: AT5G65860
ALY: 9301058
CRB: 17875279
CSAT: 104727248 104744337 104762774
EUS: EUTSA_v10005718mg
BRP: 103874022
BNA: 106346625 106348175
BOE: 106328863
RSZ: 108857199
THJ: 104807092
CPAP: 110818793
CIT: 102617746
CIC: CICLE_v10001599mg
PVY: 116129072
MINC: 123229941
TCC: 18592010
GRA: 105769321
GHI: 107905628 107958173
GAB: 108450487
HSYR: 120216608
DZI: 111312562
EGR: 104447825
GMX: 100527621 100796916
GSJ: 114408758 114414759
PVU: PHAVU_009G070400g
VRA: 106761118
VAR: 108331651
VUN: 114162111
VUM: 124843175
CCAJ: 109796001
APRC: 113865451
MTR: 25489940
TPRA: 123894299
CAM: 101504178
PSAT: 127088047
VVO: 131660823 131660831
LJA: Lj1g3v1720140.1(Lj1g3v1720140.1) Lj1g3v1720140.2(Lj1g3v1720140.2)
ADU: 107461180
AIP: 107606376
AHF: 112706449 112762445
LANG: 109343866
PCIN: 129303447
QSA: O6P43_018991
FVE: 101307454
RCN: 112174110
PPER: 18791164
PMUM: 103320401
PAVI: 110744880
PDUL: 117619808
MDM: 103441063
MSYL: 126631986
PXB: 103945293
ZJU: 107433653
MNT: 21393556
CSAV: 115698046
CSV: 101206863
CMO: 103487848
BHJ: 120075618
MCHA: 111004738
CMAX: 111495906
CMOS: 111454147
CPEP: 111798359
RCU: 8288515
HBR: 110671978
MESC: 110605917
POP: 18104803
PEU: 105128808
PALZ: 118036618
JRE: 108981343
CILL: 122319101
CAVE: 132189113
QSU: 112020323 112023925
QLO: 115971948
TWL: 120008925
VVI: 100259168
VRI: 117907434
SLY: 101264002
SPEN: 107016038
SOT: 102604578
SSTN: 125856643
SDUL: 129902169
CANN: 107867217
LBB: 132627794
NTA: 107765586 107792104
NSY: 104249239
NTO: 104107915
NAU: 109215478
INI: 109153010
ITR: 116026771
SIND: 105155586
OEU: 111389319
EGT: 105971363
SSPL: 121763244
SMIL: 131010696 131010748
SHIS: 125220850
APAN: 127257120
HAN: 110885808
ECAD: 122579428
LSV: 111901692
CCAV: 112514525
DCR: 108192844
CSIN: 114291796
RVL: 131333865
AEW: 130786245 130788315
BVG: 104902325
SOE: 110786191
CQI: 110695543 110724407
ATRI: 130826912
MOF: 131161460
NNU: 104611655
MING: 122085180
TSS: 122657333
PSOM: 113289222 113293666
OSA: 4334192
DOSA: Os03t0761200-01(Os03g0761200)
OBR: 102707569
OGL: 127768413
BDI: 100840055
ATS: 109743493
TDC: 119303236 119311910
TAES: 123105111 123113403 123122921
TUA: 125510744
LPER: 127292729
LRD: 124700614
SBI: 8062466
ZMA: 100286312
SITA: 101761593
SVS: 117838788
PVIR: 120690018
PHAI: 112873600
PDA: 103700807 120104061
EGU: 105058565
MUS: 103997354
ZOF: 121969841 122028008
DCT: 110099348
PEQ: 110023864
AOF: 109834172
MSIN: 131219012
NCOL: 116260042
ATR: 18431821
SMO: SELMODRAFT_118824 SELMODRAFT_131773
PPP: 112294549
CRE: CHLRE_01g050050v5
VCN: VOLCADRAFT_69095
MNG: MNEG_11764
CSL: COCSUDRAFT_32480
CVR: CHLNCDRAFT_144236
APRO: F751_6706
OLU: OSTLU_86989
OTA: OT_ostta04g02060
BPG: Bathy01g01620
MIS: MICPUN_56989
MPP: MICPUCDRAFT_25272(JGI:MicpuC2_25272)
SCE: YDR465C(RMT2)
SEUB: DI49_0631
SPAO: SPAR_D06450
AGO: AGOS_ADR161W
ERC: Ecym_2800
KLA: KLLA0_E03631g
KMX: KLMA_20552(RMT2)
LTH: KLTH0G05170g
VPO: Kpol_1004p62
ZRO: ZYRO0C06820g
CGR: CAGL0K06457g
NCS: NCAS_0A08140(NCAS0A08140)
NDI: NDAI_0H01030(NDAI0H01030)
TPF: TPHA_0D02720(TPHA0D02720)
TBL: TBLA_0J00700(TBLA0J00700)
TGB: HG536_0A06120
TDL: TDEL_0A04560(TDEL0A04560)
KAF: KAFR_0A06740(KAFR0A06740)
KNG: KNAG_0C06050(KNAG0C06050)
ZMK: HG535_0D05550
PPA: PAS_chr1-4_0106
DHA: DEHA2E19228g
PIC: PICST_66076(RMT2)
PGU: PGUG_03413
SPAA: SPAPADRAFT_61117
LEL: PVL30_004564(RMT2)
CAL: CAALFM_C500680WA(RMT2)
CTP: CTRG_05285
COT: CORT_0E05920
CDU: CD36_50680
CTEN: CANTEDRAFT_114589
YLI: YALI0C14718g
CLU: CLUG_04928
CLUS: A9F13_03g03025
CAUR: CJI96_0001194
SLB: AWJ20_2397(RMT2)
PKZ: C5L36_0B07540
BNN: FOA43_003317
BBRX: BRETT_004162
OPA: HPODL_00552
SLUD: SCDLUD_004911
NCR: NCU08111
NTE: NEUTE1DRAFT125124(NEUTE1DRAFT_125124)
SMP: SMAC_08035
PAN: PODANSg09947
PBEL: QC761_106790(RMT2)
PPSD: QC762_106790(RMT2)
PPSP: QC763_106790(RMT2)
PPSA: QC764_106790(RMT2)
TTT: THITE_2114023
MTM: MYCTH_2295764
CTHR: CTHT_0057220
MGR: MGG_09290
PPEI: PpBr36_07629
PGRI: PgNI_06259
TMN: UCRPA7_1231
SSCK: SPSK_10638
FGR: FGSG_00501
FPU: FPSE_04406
FPOA: FPOAC1_000520(RMT2)
FVN: FVRRES_00673
FVR: FVEG_00958
FOX: FOXG_00555
NHE: NECHADRAFT_31691
FFC: NCS54_00100800
FKR: NCS57_00099000
FMU: J7337_001038(RMT2)
TRE: TRIREDRAFT_53796
TRR: M419DRAFT_67962
MAW: MAC_02976
MAJ: MAA_04208
PCHM: VFPPC_00395
CMT: CCM_06279
AMUS: LMH87_005150
PLJ: VFPFJ_05055
PTKZ: JDV02_001441(RMT2)
VAL: VDBG_04543
VDA: VDAG_04088
CFJ: CFIO01_13485
CLUP: CLUP02_05715
CHIG: CH63R_00762
SAPO: SAPIO_CDS3344
ELA: UCREL1_5435
PFY: PFICI_01109
SSL: SS1G_01272
BFU: BCIN_11g05680(Bcrmt2)
MBE: MBM_09897
PSCO: LY89DRAFT_502650
GLZ: GLAREA_02283
ANI: ANIA_06072
AFM: AFUA_2G09080
ACT: ACLA_080890
NFI: NFIA_084610
AOR: AO090011000791
ANG: An12g04740
AFV: AFLA_008183
ALUC: AKAW2_60866A(RMT2)
ACHE: ACHE_50460A(RMT2)
APUU: APUU_11164A(RMT2)
PCS: N7525_010704
PDP: PDIP_19700
POU: POX_f08428
TMF: EYB26_001363
TRG: TRUGW13939_06032
CIM: CIMG_01019
CPW: CPC735_053400
URE: UREG_00965
PBL: PAAG_01039
PBN: PADG_03791
ABE: ARB_05048
TVE: TRV_01451
AJE: HCAG_03681
BGH: BDBG_05448
PNO: SNOG_02787 SNOG_15549
PTE: PTT_09392 PTT_15349
BZE: COCCADRAFT_112323 COCCADRAFT_96483
BSC: COCSADRAFT_105599
BOR: COCMIDRAFT_21364 COCMIDRAFT_81956
AALT: CC77DRAFT_1016203 CC77DRAFT_374429
ARAB: EKO05_0000552 EKO05_0006569
ZTR: MYCGRDRAFT_100619
PFJ: MYCFIDRAFT_38502
FFU: CLAFUR5_08805
CBET: CB0940_10726
BCOM: BAUCODRAFT_71929
NPA: UCRNP2_8449
TML: GSTUM_00004878001
SPO: SPAC26A3.17c
SOM: SOMG_00756(rmt2)
CNE: CNA04170
CNB: CNBA4000
CNG: CNAG_00434
CGI: CGB_A4280C
CDEU: CNBG_1475
TMS: TREMEDRAFT_73009
TASA: A1Q1_00168
CCAC: CcaHIS019_0304690(RMT2)
TVS: TRAVEDRAFT_112907
DSQ: DICSQDRAFT_99226
PCO: PHACADRAFT_123415
SHS: STEHIDRAFT_143419 STEHIDRAFT_163146 STEHIDRAFT_92135
HIR: HETIRDRAFT_389401
FME: FOMMEDRAFT_133950
GTR: GLOTRDRAFT_38096
RSX: RhiXN_10013
LBC: LACBIDRAFT_256162
CCI: CC1G_14139
ABP: AGABI1DRAFT71703(AGABI1DRAFT_71703)
ABV: AGABI2DRAFT204671(AGABI2DRAFT_204671)
PCUB: JR316_0002347
MPR: MPER_11317
MRR: Moror_6340
MORE: E1B28_000552
SCM: SCHCO_02634853(SCHCODRAFT_02634853)
CPUT: CONPUDRAFT_121194
SLA: SERLADRAFT_361134
WSE: WALSEDRAFT_60904
WIC: J056_001249
UMA: UMAG_11334
PFP: PFL1_04152
SGRA: EX895_001912
MGL: MGL_2081
MRT: MRET_1613
MSYM: MSY001_1151
PGR: PGTG_08661
PTRC: PtA15_7A644
PSTR: Pst134EA_013709
MLR: MELLADRAFT_46233 MELLADRAFT_74296
MBR: MONBRDRAFT_33022
SRE: PTSG_00809
SMIN: v1.2.008584.t1(symbB.v1.2.008584.t1)
PTI: PHATR_46736
FCY: FRACYDRAFT_238326
EHX: EMIHUDRAFT_246103 EMIHUDRAFT_68769
MRI: Mal4_55900
 » show all
Reference
1  [PMID:9873020]
  Authors
Niewmierzycka A, Clarke S
  Title
S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase.
  Journal
J Biol Chem 274:814-24 (1999)
DOI:10.1074/jbc.274.2.814
  Sequence
[sce:YDR465C]
Reference
2  [PMID:11856739]
  Authors
Chern MK, Chang KN, Liu LF, Tam TC, Liu YC, Liang YL, Tam MF
  Title
Yeast ribosomal protein L12 is a substrate of protein-arginine methyltransferase  2.
  Journal
J Biol Chem 277:15345-53 (2002)
DOI:10.1074/jbc.M111379200
  Sequence
[sce:YDR465C]
Reference
3  [PMID:17448464]
  Authors
Olsson I, Berrez JM, Leipus A, Ostlund C, Mutvei A
  Title
The arginine methyltransferase Rmt2 is enriched in the nucleus and co-purifies with the nuclear porins Nup49, Nup57 and Nup100.
  Journal
Exp Cell Res 313:1778-89 (2007)
DOI:10.1016/j.yexcr.2007.03.007
  Sequence
[sce:YDR465C]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.322
IUBMB Enzyme Nomenclature: 2.1.1.322
ExPASy - ENZYME nomenclature database: 2.1.1.322
BRENDA, the Enzyme Database: 2.1.1.322

  All links  
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (3772)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (362)   
   KEGG MGENES (1953)   
   RefGene (1456)   
Protein sequence (11)   
   UniProt (1)   
   RefSeq(pep) (10)   
DNA sequence (58)   
   RefSeq(nuc) (20)   
   GenBank (19)   
   EMBL (19)   
All databases (3848)   

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