KEGG ENZYME: 2.1.1.329

ENZYME: 2.1.1.329

Entry

EC 2.1.1.329                Enzyme

Name

demethylphylloquinol methyltransferase;
menG (gene name);
2-phytyl-1,4-naphthoquinol methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinol C-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + demethylphylloquinol = S-adenosyl-L-homocysteine + phylloquinol [RN:R04994]

Reaction(KEGG)

R04994

Substrate

S-adenosyl-L-methionine [CPD:C00019];
demethylphylloquinol [CPD:C21084]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
phylloquinol [CPD:C03313]

Comment

The enzyme, found in plants and cyanobacteria, catalyses the final step in the biosynthesis of phylloquinone (vitamin K1), an electron carrier associated with photosystem I. The enzyme is specific for the quinol form of the substrate, and does not act on the quinone form [3].

History

EC 2.1.1.329 created 2016

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K23095

demethylphylloquinol methyltransferase

Genes

ATH:	AT1G23360(MENG)

ALY:

9329343

CRB:

17899545

CSAT:

104741051 104756704 104776464

EUS:	EUTSA_v10008293mg

BRP:

103835666

BNA:	106411915 125577144

BOE:

106309873

RSZ:	108818956 108820890

THJ:

104822157

CPAP:

110813133

CIT:

102628556

CIC:	CICLE_v10032509mg

PVY:	116108078 116135475

MINC:

123214645

TCC:

18609512

GRA:

105785795

GHI:	107917047 107921369

GAB:

108466502

HSYR:

120134153 120145045

DZI:	111282120 111287271

EGR:

104414166

GMX:	100789470 100789973

GSJ:	114380496 114409703

PVU:	PHAVU_002G064000g

VRA:

106776995

VAR:

108335286

VUN:

114173432

VUM:

124846184

CCAJ:

109801011

APRC:

113869602

MTR:

11409460

TPRA:

123906871

CAM:

101512362

PSAT:

127119279

VVO:

131650706

LJA:	Lj2g3v1415220.1(Lj2g3v1415220.1)

ADU:	107488778 107488807

AIP:

107643333

AHF:	112749985 112801120 112801152

LANG:

109333461

PCIN:

129310359 129310868 129311291

QSA:	O6P43_025267 O6P43_033191

FVE:	101294364 101304776

RCN:

112197869

PPER:

18791522

PMUM:

103321798

PAVI:

110748068

PDUL:

117612274

MDM:	103403043 103452001

MSYL:

126607968

ZJU:	107428577 125420330

MNT:

21410343

CSAV:

115712800

CSV:

101208642

CMO:

103487713

BHJ:

120075676

MCHA:

111004744

CMAX:

111496525

CMOS:

111454302 111462490

CPEP:

111798157 111805142

RCU:

8273511

JCU:

105644633

HBR:	110631646 110673679

MESC:

110628266 110629107

POP:

7473219

PEU:

105132353

PALZ:

118037864

JRE:

109020896

CILL:

122313616

CAVE:

132178582

QSU:	112010981 112023562 112032331

QLO:	115982511 115982514

TWL:

120007078

VVI:	100246556 100256830

VRI:	117908152 117908250

SLY:

101263675

SPEN:

107005385

SOT:

102585507

SSTN:

125862708

SDUL:

129871344

CANN:

107863754

LBB:

132636106

NTA:	107824549 107827350

NSY:

104211136

NTO:

104101649

NAU:

109226748

INI:

109157980

ITR:

115998674

SIND:

105156625 105168283 105168658

OEU:

111403390

EGT:

105974760

SSPL:

121753652 121759440 121768441 121772259

SMIL:

131025306

SHIS:

125205914 125207533 125223236

APAN:

127260867 127261743

HAN:

110895055

ECAD:

122609095

LSV:

111902019

CCAV:

112524684

DCR:

108225269

CSIN:

114313633

RVL:

131310220

AEW:	130771267 130792338

BVG:

104908393

SOE:

110785625

CQI:	110694202 110709155

ATRI:

130820445

MOF:

131145064

NNU:

104593146

MING:

122076580 122079414

TSS:	122655970 122670900

PSOM:

113274264 113279492

OSA:

9270356

DOSA:

Os04t0507800-01(Os04g0507800)

OBR:

102704055

OGL:

127770111

BDI:	100831799 100836089

ATS:

109735764

TDC:	119355693 119358004 119368011

TAES:

123045984 123053859 123189733 123189751

TUA:	125529072 125537429 125538988

LPER:

127335522

LRD:

124677522

SBI:

8075905

ZMA:

100384459

SITA:

101763323

SVS:

117863501

PVIR:

120642531 120681463

PHAI:

112900296

PDA:	103703803 120107556

EGU:

105035064

MUS:

103978194

ZOF:	122010220 122017803

DCT:

110110820

PEQ:

110028315

AOF:

109828899

MSIN:

131237856

NCOL:

116248965

ATR:	105420369 105420370

SMO:	SELMODRAFT_141944 SELMODRAFT_96041

PPP:

112282043

CRE:	CHLRE_02g084300v5

VCN:	VOLCADRAFT_75878

MNG:

MNEG_1473

CSL:	COCSUDRAFT_11335

CVR:	CHLNCDRAFT_48897

APRO:

F751_2917

OLU:	OSTLU_12765

OTA:	OT_ostta07g04500

BPG:	Bathy17g02190

MIS:	MICPUN_56113

MPP:	MICPUCDRAFT_6421(JGI:MicpuC2_6421)

SYN:	sll1653(gerCb)

SYZ:	MYO_12590(gerCb)

SYY:	SYNGTS_0257(menG)

SYT:	SYNGTI_0257(menG)

SYS:	SYNPCCN_0257(menG)

SYQ:	SYNPCCP_0257(menG)

SYJ:	D082_05490(menG)

SYO:	C7I86_01340

SYC:	syc0450_d(ubiE)

SYU:	M744_11170

SYF:	Synpcc7942_1099

SYD:	Syncc9605_0809

SYE:	Syncc9902_1570

SYG:	sync_0700(ubiE)

SYR:	SynRCC307_0581(ubiE)

SYX:	SynWH7803_1772(ubiE)

CYA:	CYA_2236(ubiE)

CYB:	CYB_0364(ubiE)

SYNE:

Syn6312_1947

SYNP:

Syn7502_00638

SYNK:

KR100_12025

SYNR:

KR49_13190

SYND:

KR52_12890

SYH:	Syncc8109_1901

SYNW:

SynWH8103_01905(MENG)

SYNC:

CB0101_13770(ubiE)

SYNY:

BM449_03640

DSL:	Dacsa_2146

SYW:

SYNW1674

CGC:	Cyagr_1377

CYI:	CBM981_1477(ubiE)

PMA:	Pro_0427(ubiE_menG)

PMM:

PMM0431

PMT:	PMT_0275 PMT_0276

PMN:	PMN2A_1762

PMI:	PMT9312_0430

PMB:	A9601_04861(ubiE)

PMC:	P9515_04931(ubiE)

PMF:	P9303_20621(ubiE)

PMG:	P9301_04551(ubiE)

PMH:	P9215_05101(ubiE)

PMJ:	P9211_04271(ubiE)

PME:	NATL1_04841(ubiE)

PRC:

EW14_0473

PRM:

EW15_0514

WNA:	KA717_29640(ubiE)

CMP:	Cha6605_5136

CYN:	Cyan7425_2785

CEP:	Cri9333_3867

TVN:	NIES2134_103300

SLW:	BRW62_11985

AMR:	AM1_3823(ubiE)

ACAM:

HRE53_15880(ubiE)

TEL:

tll2373

THN:	NK55_08730(menG)

THEC:

FFX45_06660(ubiE)

TSZ:	OOK60_11470(ubiE)

LEN:	LEP3755_33110

LET:	O77CONTIG1_02831(ubiE_3)

LBO:	LBWT_24850

KOV:	K9N68_18360(ubiE)

LSC:	KIK02_00470(ubiE)

LSK:	J5X98_01315(ubiE)

HHG:	XM38_011590

PSEU:

Pse7367_1658

PSER:

ABRG53_2868(ubiE)

PGX:	OA858_19455(ubiE)

THEU:

HPC62_16825(ubiE)

TOG:	HNI00_00150(ubiE)

TSIN:

OXH18_19465(ubiE)

GLP:	Glo7428_1593

CHON:

NIES4102_28550

GDU:	P0S91_18060(ubiE)

GEN:	GM3709_1554

GEE:	GM3708_3178

CAN:	Cyan10605_0543

CSN:	Cyast_2552

CYL:	AA637_02565(menG)

SYP:	SYNPCC7002_A1100(menG)

SYV:	AWQ23_05660

SYL:	AWQ21_05650

LEP:	Lepto7376_4061

SYNN:

NIES970_14450(menG)

MAR:	MAE_37840(ubiE)

MPK:

VL20_5484

MIQ:	B5D77_02000

MVZ:	myaer102_12660(ubiE)

HAO:	PCC7418_0313

ENN:	FRE64_10265(ubiE)

CYU:	UCYN_00120

CYT:	cce_2570(ubiE)

CWA:	CwatDRAFT_4679

CYP:	PCC8801_2496

CYH:	Cyan8802_3610

CYC:	PCC7424_0747

CYJ:	Cyan7822_5318

TER:

Tery_3972

ARP:	NIES39_K03190

PAGH:

NIES204_15890

PPSU:

NO713_03669(menG)

PRUN:

PCC7821_01850(menG)

OXY:	HCG48_04760(ubiE)

MVAG:

D0A34_25885(ubiE)

LFS:	HFV01_01615(ubiE)

OAC:	Oscil6304_0831

ONI:	Osc7112_5572

PHOR:

JWS08_21540(ubiE)

PYH:	NEA10_10385(ubiE)

MIC:	Mic7113_0668

GEI:	GEI7407_0380

GVI:	gll0127(menG)

GLJ:	GKIL_3721(ubiE)

GML:	ISF26_07390(ubiE)

ANA:

alr5252

NPU:	Npun_R4434

NOS:	Nos7107_2553

NOP:	Nos7524_3345

NON:	NOS3756_08110(ubiE)

NFL:	COO91_03075

NOE:	CLI64_12695

NSH:

GXM_03248

NED:	HUN01_23220(ubiE)

NPZ:	ACX27_10055

AVA:

Ava_1422

NAZ:

Aazo_4318

ANB:	ANA_C12287

ACY:	Anacy_5065

AWA:	AA650_24965

ANN:	EH233_26810

CSG:	Cylst_6194

RSIN:

B6N60_03154

HBQ:	QI031_13370(ubiE)

CALO:

Cal7507_4755

CALT:

Cal6303_3738

CALH:

IJ00_11885

CALN:

NIES2098_70430(ubiE)

CALS:

NIES3974_25770(ubiE)

RIV:	Riv7116_5407

FIS:	FIS3754_46880

NSP:	BMF81_01745(ubiE)

NSPH:

BDGGKGIB_02443(menG_2)

DOU:	BMF77_00341(menG_1)

DFS:	HGD76_16465(ubiE)

DHT:	NG743_10885(ubiE)

CCUR:

IAR63_05630(ubiE)

CRK:	L3I90_06125(ubiE)

AFLO:

HEQ12_03675(ubiE)

STOQ:

K2F26_20180(ubiE)

AEE:	IM676_07415(ubiE)

RCS:	NIES932_30780

TOQ:	HCG51_17670(ubiE)

ALAX:

NIES50_26520(ubiE)

NCN:	BZZ01_18990

CTHE:

Chro_1764

PLP:	Ple7327_3669

SCS:	Sta7437_4306

STAN:

STA3757_37130

GLT:	GlitD10_0356(ubiE)

GCY:	LQF76_00950(ubiE)

» show all

Reference

1 [PMID:11772039]

Authors

Sakuragi Y, Zybailov B, Shen G, Jones AD, Chitnis PR, van der Est A, Bittl R, Zech S, Stehlik D, Golbeck JH, Bryant DA

Title

Insertional inactivation of the menG gene, encoding 2-phytyl-1,4-naphthoquinone methyltransferase of Synechocystis sp. PCC 6803, results in the incorporation of 2-phytyl-1,4-naphthoquinone into the A(1) site and alteration of the equilibrium constant between A(1) and F(X) in photosystem I.

Journal

Biochemistry 41:394-405 (2002)
DOI:10.1021/bi011297w

Sequence

[syn:sll1653]

Reference

2 [PMID:17082184]

Authors

Lohmann A, Schottler MA, Brehelin C, Kessler F, Bock R, Cahoon EB, Dormann P

Title

Deficiency in phylloquinone (vitamin K1) methylation affects prenyl quinone distribution, photosystem I abundance, and anthocyanin accumulation in the Arabidopsis AtmenG mutant.

Journal

J Biol Chem 281:40461-72 (2006)
DOI:10.1074/jbc.M609412200

Sequence

[ath:AT1G23360]

Reference

3 [PMID:26023160]

Authors

Fatihi A, Latimer S, Schmollinger S, Block A, Dussault PH, Vermaas WF, Merchant SS, Basset GJ

Title

A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.

Journal

Plant Cell 27:1730-41 (2015)
DOI:10.1105/tpc.15.00103