KEGG   ENZYME: 2.1.1.330
Entry
EC 2.1.1.330                Enzyme                                 
Name
5'-demethylyatein 5'-O-methyltransferase;
OMT1 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(-)-5'-demethylyatein 5'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (-)-5'-demethylyatein = S-adenosyl-L-homocysteine + (-)-yatein [RN:R11545]
Reaction(KEGG)
R11545
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(-)-5'-demethylyatein [CPD:C21184]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(-)-yatein [CPD:C10557]
Comment
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs.
History
EC 2.1.1.330 created 2016
Pathway
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21204  5'-demethylyatein 5'-O-methyltransferase
Reference
1  [PMID:26359402]
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
  Sequence
[ag:ALG05117]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.330
IUBMB Enzyme Nomenclature: 2.1.1.330
ExPASy - ENZYME nomenclature database: 2.1.1.330
BRENDA, the Enzyme Database: 2.1.1.330

  All links  
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (6)   
   InterPro (6)   
All databases (23)   

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