| Entry |
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| Name |
4-amino-anhydrotetracycline N4-methyltransferase;
oxyT (gene name);
ctcO (gene name)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:(4S,4aS,12aS)-4-amino-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide Nalpha-methyltransferase
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| Reaction(IUBMB) |
(1) S-adenosyl-L-methionine + 4-amino-4-de(dimethylamino)anhydrotetracycline = S-adenosyl-L-homocysteine + 4-methylamino-4-de(dimethylamino)anhydrotetracycline [RN: R11520];
(2) S-adenosyl-L-methionine + 4-methylamino-4-de(dimethylamino)anhydrotetracycline = S-adenosyl-L-homocysteine + anhydrotetracycline [RN: R11521]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
4-amino-4-de(dimethylamino)anhydrotetracycline [CPD: C06654];
4-methylamino-4-de(dimethylamino)anhydrotetracycline [CPD: C21436]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
4-methylamino-4-de(dimethylamino)anhydrotetracycline [CPD: C21436];
anhydrotetracycline [CPD: C02811]
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| Comment |
The enzyme, characterized from the bacterium Streptomyces rimosus, participates in the biosynthesis of tetracycline antibiotics.
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| History |
EC 2.1.1.335 created 2016
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| Pathway |
| ec01057 | Biosynthesis of type II polyketide products |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K14255 | 4-amino-anhydrotetracycline N4-methyltransferase |
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| Genes |
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| Reference |
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| Authors |
Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J |
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| Title |
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.335 |
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