Entry
Name
xanthohumol 4-O-methyltransferase;
OMT2 (ambiguous);
S-adenosyl-L-methionine:xanthohumol 4'-O-methyltransferase (incorrect);
xanthohumol 4'-O-methyltransferase (incorrect)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:xanthohumol 4-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + xanthohumol = S-adenosyl-L-homocysteine + 4-O-methylxanthohumol [RN:
R12264 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
xanthohumol [CPD:
C16417 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
4-O-methylxanthohumol [CPD:
C22048 ]
Comment
The enzyme from hops (Humulus lupulus) has a broad substrate specificity. The best substrates in vitro are resveratrol, desmethylxanthohumol, naringenin chalcone and isoliquiritigenin.
History
EC 2.1.1.339 created 2017, modified 2018
Pathway
Orthology
K21582 xanthohumol 4'-O-methyltransferase
Reference
Authors
Nagel J, Culley LK, Lu Y, Liu E, Matthews PD, Stevens JF, Page JE
Title
EST analysis of hop glandular trichomes identifies an O-methyltransferase that catalyzes the biosynthesis of xanthohumol.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.339