Entry Name 3-aminomethylindole N-methyltransferase;
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:3-(aminomethyl)indole N-methyltransferase (gramine-forming)
Reaction(IUBMB) 2 S-adenosyl-L-methionine + 3-(aminomethyl)indole = 2 S-adenosyl-L-homocysteine + gramine (overall reaction) [RN:
R11697 ];
(1a) S-adenosyl-L-methionine + 3-(aminomethyl)indole = S-adenosyl-L-homocysteine + (1H-indol-3-yl)-N-methylmethanamine [RN:
R11698 ];
(1b) S-adenosyl-L-methionine + (1H-indol-3-yl)-N-methylmethanamine = S-adenosyl-L-homocysteine + gramine [RN:
R11699 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
3-(aminomethyl)indole [CPD:
C21601 ];
(1H-indol-3-yl)-N-methylmethanamine [CPD:
C21602 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
gramine [CPD:
C08304 ];
(1H-indol-3-yl)-N-methylmethanamine [CPD:
C21602 ]
Comment The enzyme, characterized from Hordeum vulgare (barley), catalyses two successive N-methylation reactions during the biosynthesis of gramine, a toxic indole alkaloid.
History EC 2.1.1.340 created 2017
Pathway ec00999 Biosynthesis of various plant secondary metabolites
ec01110 Biosynthesis of secondary metabolites
Orthology K21937 3-aminomethylindole N-methyltransferase
Reference Authors Leland TJ, Hanson AD
Title Induction of a Specific N-Methyltransferase Enzyme by Long-Term Heat Stress during Barley Leaf Growth.
Journal Reference Authors Larsson KA, Zetterlund I, Delp G, Jonsson LM
Title N-Methyltransferase involved in gramine biosynthesis in barley: cloning and characterization.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.340
