Entry
Name
ornithine lipid N-methyltransferase;
olsG (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:ornithine lipid N-methyltransferase
Reaction(IUBMB)
3 S-adenosyl-L-methionine + an ornithine lipid = 3 S-adenosyl-L-homocysteine + an N,N,N-trimethylornithine lipid (overall reaction) [RN:
R11797 ];
(1a) S-adenosyl-L-methionine + an ornithine lipid = S-adenosyl-L-homocysteine + an N-methylornithine lipid [RN:
R11798 ];
(1b) S-adenosyl-L-methionine + an N-methylornithine lipid = S-adenosyl-L-homocysteine + an N,N-dimethylornithine lipid [RN:
R11799 ];
(1c) S-adenosyl-L-methionine + an N,N-dimethylornithine lipid = S-adenosyl-L-homocysteine + an N,N,N-trimethylornithine lipid [RN:
R11800 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
ornithine lipid [CPD:
C21672 ];
N-methylornithine lipid [CPD:
C21673 ];
N,N-dimethylornithine lipid [CPD:
C21674 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
N,N,N-trimethylornithine lipid [CPD:
C21675 ];
N-methylornithine lipid [CPD:
C21673 ];
N,N-dimethylornithine lipid [CPD:
C21674 ]
Comment
The enzyme, characterized from the bacterium Singulisphaera acidiphila, catalyses three successive methylations of the terminal delta-nitrogen in ornithine lipids.
History
EC 2.1.1.344 created 2017
Orthology
K22309 ornithine lipid N-methyltransferase
Genes
PBOR : BSF38_01809(rsmA_1)
Taxonomy
Reference
Authors
Escobedo-Hinojosa WI, Vences-Guzman MA, Schubotz F, Sandoval-Calderon M, Summons RE, Lopez-Lara IM, Geiger O, Sohlenkamp C
Title
OlsG (Sinac_1600) Is an Ornithine Lipid N-Methyltransferase from the Planctomycete Singulisphaera acidiphila.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.344