| Entry |
|
|---|
| Name |
psilocybin synthase;
PsiM
|
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
|---|
| Sysname |
S-adenosyl-L-methionine:4-hydroxytryptamine-4-phosphate N,N-dimethyltransferase
|
|---|
| Reaction(IUBMB) |
2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = 2 S-adenosyl-L-homocysteine + psilocybin (overall reaction) [RN: R11934];
(1a) S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate = S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine 4-phosphate [RN: R11935];
(1b) S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine 4-phosphate = S-adenosyl-L-homocysteine + psilocybin [RN: R11936]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
4-hydroxytryptamine 4-phosphate [CPD: C21778];
4-hydroxy-N-methyltryptamine 4-phosphate [CPD: C21779]
|
|---|
| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
psilocybin [CPD: C07576];
4-hydroxy-N-methyltryptamine 4-phosphate [CPD: C21779]
|
|---|
| Comment |
Isolated from the fungus Psilocybe cubensis. The product, psilocybin, is a psychoactive compound.
|
|---|
| History |
EC 2.1.1.345 created 2017
|
|---|
| Pathway |
| ec00901 | Indole alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
|
|---|
| Genes |
|
|---|
| Reference |
|
|---|
| Authors |
Fricke J, Blei F, Hoffmeister D |
|---|
| Title |
Enzymatic Synthesis of Psilocybin. |
|---|
| Journal |
|
|---|
| Sequence |
|
|---|
| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.345 |
|
|---|
