Entry
Name
tRNA (uracil54-C5)-methyltransferase;
transfer RNA uracil54 5-methyltransferase;
transfer RNA uracil54 methylase;
tRNA uracil54 5-methyltransferase;
m5U54-methyltransferase;
tRNA:m5U54-methyltransferase;
RUMT;
TrmA;
5-methyluridine54 tRNA methyltransferase;
tRNA(uracil-54,C5)-methyltransferase;
Trm2;
tRNA(m5U54)methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:tRNA (uracil54-C5)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + uracil54 in tRNA = S-adenosyl-L-homocysteine + 5-methyluracil54 in tRNA [RN:
R00594 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
uracil54 in tRNA
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
5-methyluracil54 in tRNA
Comment
Unlike this enzyme, EC
2.1.1.74 (methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase (FADH2-oxidizing)), uses 5,10-methylenetetrahydrofolate and FADH2 to supply the atoms for methylation of U54 [4].
History
EC 2.1.1.35 created 1972, modified 2011
Orthology
K00557 tRNA (uracil-5-)-methyltransferase
K15331 tRNA (uracil-5-)-methyltransferase
Genes
HMH : 116457905 116811867(TRMT2B)
PANU : 101001651(TRMT2B) 116268528
MORG : 121436711 121437223
MDO : 100020295(TRMT2B) 100023388
GAS : 123234412 123241917(TRMT2B) 123255960
MASI : 127412134 127414089
HAZT : 108664681 108678009
PPOI : 119107299 119107886
NCS : NCAS_0B08100(NCAS0B08100)
NDI : NDAI_0B05410(NDAI0B05410)
TPF : TPHA_0A02980(TPHA0A02980)
TBL : TBLA_0D05720(TBLA0D05720)
TDL : TDEL_0H00960(TDEL0H00960)
KAF : KAFR_0G00670(KAFR0G00670)
KNG : KNAG_0C01250(KNAG0C01250)
DHA : DEHA2D15114g DEHA2F20042g
PGU : PGUG_00289 PGUG_00555
SPAA : SPAPADRAFT_131185 SPAPADRAFT_70432
CAL : CAALFM_C101380CA(TRM2) CAALFM_CR03660CA(CaO19.4365)
CTP : CTRG_00733 CTRG_04438
COT : CORT_0A01960 CORT_0B10250
CDU : CD36_01280 CD36_28860
CTEN : CANTEDRAFT_114235 CANTEDRAFT_130808
CLU : CLUG_01981 CLUG_02338
CLUS : A9F13_02g03113 A9F13_22g00572
CAUR : CJI96_0001386 CJI96_0004302
NTE : NEUTE1DRAFT65476(NEUTE1DRAFT_65476)
BFU : BCIN_13g05480(Bctrm2)
CCAC : CcaHIS019_0304220(TRM2)
PPL : POSPLDRAFT_31722 POSPLDRAFT_31731
ABP : AGABI1DRAFT64825(AGABI1DRAFT_64825)
ABV : AGABI2DRAFT211317(AGABI2DRAFT_211317)
FCY : FRACYDRAFT_149228 FRACYDRAFT_238614
ECOO : ECRM13514_5085(trmA)
ECOH : ECRM13516_4821(trmA)
ECW : EcE24377A_4506(trmA)
EDJ : ECDH1ME8569_3833(trmA)
ECOI : ECOPMV1_04373(trmA)
REE : electrica_04932(trmA)
RTG : NCTC13098_07076(trmA)
CLAP : NCTC11466_04471(trmA)
KIE : NCTC12125_03645(trmA)
AHN : NCTC12129_04803(trmA)
METY : MRY16398_54830(trmA)
PSHI : SAMEA2665130_2827(trmA)
YPG : YpAngola_A0122(trmA)
YPI : YpsIP31758_0141(trmA)
SMW : SMWW4_v1c47010(trmA)
SFJ : SAMEA4384070_4705(trmA)
SOF : NCTC11214_01503(trmA)
SERA : Ser39006_003625(trmA)
PAQU : DMB82_0000880(trmA)
DIC : Dpoa569_000180(trmA)
TPTY : NCTC11468_03665(trmA)
PHEI : NCTC12003_03821(trmA)
PRJ : NCTC6933_03843(trmA)
LRI : NCTC12151_03368(trmA)
HIC : NTHIC486_00127(trmA)
HPIT : NCTC13334_00456(trmA)
HHZ : NCTC10839_00814(trmA)
HAEG : NCTC8502_00157(trmA)
PDAG : 4362423_01966(trmA)
ADP : NCTC12871_01047(trmA)
ALIG : NCTC10568_02374(trmA2)
ASEG : NCTC10977_00346(trmA)
AVT : NCTC3438_00127(trmA)
RPNE : NCTC8284_00464(trmA_2)
PAET : NCTC13378_01983(trmA)
VAU : VANGNB10_cI0118c(trmA)
VPL : SA104470976_02585(trmA)
PAEB : NCGM1900_5449(trmA)
PPRC : PFLCHA0_c53450(trmA)
PMUD : NCTC8068_04579(trmA)
PFW : PF1751_v1c47730(trmA)
PPUU : PputUW4_04716(trmA)
PTRT : HU722_0025700(trmA)
PTW : TUM18999_10960(trmA)
PTAE : NCTC10697_00711(trmA)
SCAA : TUM17387_01760(trmA)
SALH : HMF8227_02021(trmA)
TIB : THMIRHAM_02220(trmA)
TSE : THMIRHAS_02340(trmA)
TZO : THMIRHAT_20300(trmA)
AEL : NCTC12917_00122(trmA)
CHJ : NCTC10426_01644(trmA)
CDIZ : CEDIAZO_00647(trmA)
NMM : NMBM01240149_0504(trmA)
NMS : NMBM01240355_1606(trmA)
NMQ : NMBM04240196_0552(trmA)
NMZ : NMBNZ0533_1658(trmA)
NMX : NMA510612_2183(trmA)
NWE : SAMEA3174300_0890(trmA)
NZO : SAMEA4504057_1429(trmA)
NCI : NCTC10296_01704(trmA)
NCZ : NCTC10294_01143(trmA)
NANI : NCTC12227_00502(trmA)
ECOR : SAMEA4412678_0775(trmA)
PLG : NCTC10937_00904(trmA)
LMIR : NCTC12852_02248(trmA)
LAS : CLIBASIA_04505(trmA)
HCL : NCTC13205_01328(trmA)
HPUL : NCTC13154_01066(trmA)
CJV : MTVDSCj20_0836(trmA)
CFV : CFVI03293_0781(trmA)
CAMP : CFT03427_0966(trmA)
CCOC : CCON33237_0634(trmA)
CLR : UPTC16701_0937(trmA)
CLM : UPTC16712_0968(trmA)
CAMR : CAQ16704_0957(trmA)
CHV : CHELV3228_0933(trmA)
CPIN : CPIN18020_0160(trmA)
CAMZ : CVIC12175_0806(trmA)
» show all
Taxonomy
Reference
Authors
Bjork GR, Svensson I
Title
Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae.
Journal
Reference
Authors
Greenberg R, Dudock B
Title
Isolation and chracterization of m5U-methyltransferase from Escherichia coli.
Journal
J Biol Chem 255:8296-302 (1980)
Reference
Authors
HURWITZ J, GOLD M, ANDERS M.
Title
THE ENZYMATIC METHYLATION OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID. 3. PURIFICATION OF SOLUBLE RIBONUCLEIC ACID-METHYLATING ENZYMES.
Journal
J Biol Chem 239:3462-73 (1964)
Reference
Authors
Delk AS, Nagle DP Jr, Rabinowitz JC.
Title
Methylenetetrahydrofolate-dependent biosynthesis of ribothymidine in transfer RNA of Streptococcus faecalis. Evidence for reduction of the 1-carbon unit by FADH2.
Journal
J Biol Chem 255:4387-90 (1980)
Reference
Authors
Kealey JT, Gu X, Santi DV.
Title
Enzymatic mechanism of tRNA (m5U54)methyltransferase.
Journal
Reference
Authors
Gu X, Ivanetich KM, Santi DV.
Title
Recognition of the T-arm of tRNA by tRNA (m5U54)-methyltransferase is not sequence specific.
Journal
Reference
Authors
Becker HF, Motorin Y, Sissler M, Florentz C, Grosjean H.
Title
Major identity determinants for enzymatic formation of ribothymidine and pseudouridine in the T psi-loop of yeast tRNAs.
Journal
Reference
Authors
Walbott H, Leulliot N, Grosjean H, Golinelli-Pimpaneau B
Title
The crystal structure of Pyrococcus abyssi tRNA (uracil-54, C5)-methyltransferase provides insights into its tRNA specificity.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.35
ExPASy - ENZYME nomenclature database: 2.1.1.35