Entry Name 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase
Class Transferases;BRITE hierarchy
Sysname S-adenosyl-L-methionine:3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase
Reaction(IUBMB) S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine = S-adenosyl-L-homocysteine + 3-O-acetylpapaveroxine [RN:
R11692 ]
Reaction(KEGG) Substrate S-adenosyl-L-methionine [CPD:
C00019 ];
3-O-acetyl-4'-O-demethylpapaveroxine [CPD:
C21590 ]
Product S-adenosyl-L-homocysteine [CPD:
C00021 ];
3-O-acetylpapaveroxine [CPD:
C21591 ]
Comment This activity is part of the noscapine biosynthesis pathway, as characterized in the plant Papaver somniferum (opium poppy). It is catalysed by heterodimeric complexes of the OMT2 gene product and the product of either OMT3 or 6OMT. OMT2 is the catalytic subunit in both complexes.
History EC 2.1.1.352 created 2018
Pathway ec00950 Isoquinoline alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K23157 3-O-acetyl-4'-O-demethylpapaveroxine 4'-O-methyltransferase subunit OMT2
Genes Taxonomy Reference Authors Li Y, Smolke CD
Title Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.
Journal Reference Authors Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ
Title Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.1.1.352
