Entry
Name
demethylluteothin O-methyltransferase;
aurI (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:demethylluteothin O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + demethylluteothin = S-adenosyl-L-homocysteine + luteothin [RN:
R12336 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
demethylluteothin [CPD:
C22086 ]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
luteothin [CPD:
C22079 ]
Comment
The enzyme, characterized from the bacterium Streptomyces thioluteus, participates in the biosynthesis of the antibiotic aureothin. An orthologous enzyme in the bacteria Streptomyces orinoci and Streptomyces spectabilis catalyses a similar reaction in the biosynthesis of spectinabilin.
History
EC 2.1.1.353 created 2019
Orthology
K23394 demethylluteothin O-methyltransferase
Reference
Authors
He J, Muller M, Hertweck C
Title
Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome p450 monooxygenase.
Journal
Reference
Authors
Muller M, He J, Hertweck C
Title
Dissection of the late steps in aureothin biosynthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.1.1.353