KEGG ENZYME: 2.1.1.359

ENZYME: 2.1.1.359

Entry

EC 2.1.1.359                Enzyme

Name

[histone H3]-lysine36 N-trimethyltransferase;
SET2 (gene name);
KMT3A (gene name)

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:[histone H3]-L-lysine36 N6-trimethyltransferase

Reaction(IUBMB)

3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36 (overall reaction);
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36;
(1b) S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36;
(1c) S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36

Reaction(KEGG)

(other) R03875 R04866 R04867

Substrate

S-adenosyl-L-methionine [CPD:C00019];
[histone H3]-L-lysine36;
[histone H3]-N6-methyl-L-lysine36;
[histone H3]-N6,N6-dimethyl-L-lysine36

Product

S-adenosyl-L-homocysteine [CPD:C00021];
[histone H3]-N6,N6,N6-trimethyl-L-lysine36;
[histone H3]-N6-methyl-L-lysine36;
[histone H3]-N6,N6-dimethyl-L-lysine36

Comment

The enzyme, characterized from yeast and mammals, catalyses the successive methylation of lysine36 of histone H3 (H3K36), forming the trimethylated form. These modifications influence the binding of chromatin-associated proteins. The enzyme couples the methylation reactions with transcriptional elongation through an interaction with the large subunit of RNA polymerase II. cf. EC 2.1.1.357, [histone H3]-lysine36 N-dimethyltransferase.

History

EC 2.1.1.359 created 1976 as EC 2.1.1.43, modified 1982, modified 1983, part transferred 2019 to EC 2.1.1.359

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K11423

[histone H3]-lysine36 N-trimethyltransferase

K23700

[histone H3]-lysine36 N-trimethyltransferase

Genes

HSA:	29072(SETD2)

PTR:	460331(SETD2)

PPS:	100993006(SETD2)

GGO:	101132140(SETD2)

PON:	100433116(SETD2)

NLE:	100584442(SETD2)

HMH:	116473532(SETD2)

MCC:	711825(SETD2)

MCF:	102121581(SETD2)

MTHB:

126948577

MNI:

105480624

CSAB:

103227561(SETD2)

CATY:

105573623(SETD2)

PANU:

101026986(SETD2)

TGE:	112618523(SETD2)

MLEU:

105540477(SETD2)

RRO:	104671311(SETD2)

RBB:	108517641(SETD2)

TFN:	117080326(SETD2)

PTEH:

111555466(SETD2)

CANG:

105509827(SETD2)

CJC:	100411953(SETD2)

SBQ:	101034613(SETD2)

CIMI:

108305438(SETD2)

CSYR:

103273788(SETD2)

MMUR:

105874896(SETD2)

LCAT:

123623336(SETD2)

PCOQ:

105827280(SETD2)

OGA:	100950439(SETD2)

MMU:	235626(Setd2)

MCAL:

110301050(Setd2)

MPAH:

110328077(Setd2)

RNO:	316013(Setd2)

MCOC:

116072571(Setd2)

ANU:	117693276(Setd2)

MUN:	110554986(Setd2)

CGE:	100765637(Setd2)

MAUA:

101830442(Setd2)

PROB:

127235952(Setd2)

PLEU:

114705174(Setd2)

MORG:

121464185(Setd2)

MFOT:

126499805

AAMP:

119808984(Setd2)

NGI:	103732034(Setd2)

CPOC:

100719166(Setd2)

CCAN:

109689470(Setd2)

DORD:

105996211(Setd2)

DSP:	122126928(Setd2)

PLOP:

125342285(Setd2)

NCAR:

124969403

MMMA:

107145083(Setd2)

OCU:

100351499

OPI:	101516490(SETD2)

TUP:	102477917(SETD2)

GVR:	103591229(SETD2)

CFA:	476643(SETD2)

CLUD:

112666853(SETD2)

VVP:	112912390(SETD2)

VLG:	121494650(SETD2)

NPO:	129521732(SETD2)

AML:	100466135(SETD2)

UMR:	103675118(SETD2)

UAH:	113256807(SETD2)

UAR:	123779799(SETD2)

ELK:

111144347

LLV:

125081004

MPUF:

101681942(SETD2)

MNP:	132011261(SETD2)

MLK:	131823866(SETD2)

NVS:	122909482(SETD2)

ORO:	101365495(SETD2)

EJU:	114196503(SETD2)

ZCA:	113916609(SETD2)

MLX:	118005368(SETD2)

NSU:	110577582(SETD2)

LWW:	102727823(SETD2)

FCA:	101085029(SETD2)

PYU:	121026806 121026808

PCOO:

112852684(SETD2)

PBG:	122487199(SETD2)

PVIV:

125154219(SETD2)

LRUF:

124523532

PTG:	102955436(SETD2)

PPAD:

109247730(SETD2)

PUC:

125930654

AJU:

106969033

HHV:	120229315(SETD2)

BTA:	539860(SETD2)

BOM:	102266643(SETD2)

BIU:	109575988(SETD2)

BBUB:

102393639(SETD2)

BBIS:

105004686(SETD2)

CHX:	102183113(SETD2)

OAS:	101114649(SETD2)

BTAX:

128044432(SETD2)

ODA:	120868180(SETD2)

CCAD:

122424798(SETD2)

MBEZ:

129547776(SETD2)

SSC:	100623101(SETD2)

CFR:	102512396(SETD2)

CBAI:

105072880(SETD2)

CDK:	105103636(SETD2)

VPC:	102531919(SETD2)

BACU:

102997833(SETD2)

BMUS:

118903175(SETD2)

LVE:	103086894(SETD2)

OOR:	101269476 101280364(SETD2) 101282703 125961717

DLE:	111174450(SETD2)

PCAD:

112064944(SETD2)

PSIU:

116742461 116742477 116761205 116761609(SETD2) 116764505

NASI:

112403750(SETD2)

ECB:	100064888(SETD2)

EPZ:	103551032(SETD2)

EAI:	106823246(SETD2)

MYB:	102260404(SETD2)

MYD:	102758485(SETD2)

MMYO:

118668537(SETD2)

MLF:	102435793(SETD2)

PKL:	118714790(SETD2)

EFUS:

103299125(SETD2)

MNA:	107529409(SETD2)

DRO:	112309866(SETD2)

SHON:

118976190(SETD2)

AJM:	119037871(SETD2)

PDIC:

114501512(SETD2)

PHAS:

123830508(SETD2)

MMF:	118633365(SETD2)

PPAM:

129087631(SETD2)

HAI:	109376628(SETD2)

RFQ:	117036580(SETD2)

PALE:

102884085(SETD2)

PGIG:

120582282(SETD2)

PVP:	105302344(SETD2)

RAY:	107509112(SETD2)

MJV:	108400455(SETD2) 108401248 118966919

TOD:	119259277(SETD2)

SARA:

101550871(SETD2)

LAV:	100655356(SETD2)

TMU:

101343139

ETF:	101642970(SETD2)

DNM:	101433648(SETD2)

MDO:	100024848(SETD2)

GAS:	123252909(SETD2)

SHR:	100931646(SETD2)

PCW:	110217008(SETD2)

OAA:	114816148(SETD2)

GGA:	420404(SETD2)

PCOC:

116238217(SETD2)

MGP:	100539457(SETD2)

CJO:	107308808(SETD2)

TPAI:

128087412(SETD2)

LMUT:

125695638(SETD2)

NMEL:

110393293(SETD2)

APLA:

113842604(SETD2)

ACYG:

106046805(SETD2)

CATA:

118251837(SETD2)

AFUL:

116486033(SETD2)

TGU:	100224614(SETD2)

LSR:	110476945(SETD2)

SCAN:

103813035(SETD2)

PMOA:

120510532(SETD2)

OTC:	121337966(SETD2)

PRUF:

121351804(SETD2)

GFR:	102039322(SETD2)

FAB:	101814785(SETD2)

OMA:	130249334(SETD2)

PHI:	102106397(SETD2)

PMAJ:

107215411(SETD2)

CCAE:

111925482(SETD2)

CCW:	104686490(SETD2)

CBRC:

103623957(SETD2)

ETL:	114070402(SETD2)

ZAB:	102070924(SETD2)

ACHL:

103808009(SETD2)

SVG:	106862800(SETD2)

MMEA:

130574556(SETD2)

HRT:	120754330(SETD2)

FPG:	101913975(SETD2)

FCH:	102053248(SETD2)

CLV:	102098192(SETD2)

EGZ:	104123260(SETD2)

NNI:	104019238(SETD2)

PCRI:

104035741(SETD2)

PLET:

104618506(SETD2)

EHS:	104510412(SETD2)

PCAO:

104043224(SETD2)

ACUN:

113476423(SETD2)

TALA:

104358172(SETD2)

PADL:

103916778(SETD2)

AFOR:

103903408(SETD2)

ACHC:

115338781(SETD2)

HALD:

104322327

HLE:	104829204(SETD2)

AGEN:

126038089

GCL:

127012720

CCRI:

104159334(SETD2)

CMAC:

104473045(SETD2)

MUI:	104544284(SETD2)

BREG:

104641398(SETD2)

FGA:	104082936(SETD2)

GSTE:

104255118

LDI:	104353735(SETD2)

OHA:	104332883(SETD2)

NNT:

104407506

SHAB:

115611158(SETD2)

DPUB:

104306779(SETD2)

PGUU:

104457667(SETD2)

ACAR:

104529664(SETD2)

CPEA:

104387994(SETD2)

AVIT:

104275817(SETD2)

CVF:	104289689(SETD2)

RTD:	128906101(SETD2)

CUCA:

104055045(SETD2)

TEO:	104378282(SETD2)

BRHI:

104493974(SETD2)

AROW:

112977399(SETD2)

NPD:	112947562 112951575

TGT:	104570962(SETD2)

DNE:	112992776(SETD2)

SCAM:

104150107(SETD2)

ASN:	102378063(SETD2)

AMJ:	102567964(SETD2)

CPOO:

109306447(SETD2)

GGN:	109291156(SETD2)

PSS:	102460966(SETD2)

CMY:	102947543(SETD2)

CCAY:

125631124(SETD2)

DCC:	119851175(SETD2)

CPIC:

101953039(SETD2)

TST:	117871919(SETD2)

CABI:

116819138(SETD2)

MRV:	120397709(SETD2)

ACS:	100559621(setd2)

ASAO:

132779047(SETD2)

PVT:	110069987(SETD2)

SUND:

121933414(SETD2)

PBI:	103055763(SETD2)

PMUR:

107286005(SETD2)

CTIG:

120319695(SETD2)

TSR:	106542655(SETD2)

PGUT:

117656347(SETD2)

APRI:

131196724(SETD2)

PTEX:

113452005(SETD2)

NSS:	113427149(SETD2)

VKO:	123020920(SETD2)

PMUA:

114607160(SETD2)

PRAF:

128423845(SETD2)

ZVI:	118091669(SETD2)

HCG:	128329599(SETD2)

GJA:	107120098(SETD2)

STOW:

125440838(SETD2)

EMC:	129338042(SETD2)

XLA:	108718681(setd2.L) 108719797(setd2.S)

XTR:	100492810(setd2)

RTEM:

120941687(SETD2)

BBUF:

121000811(SETD2)

BGAR:

122938723(SETD2)

MUO:	115465989(SETD2)

GSH:	117354403(SETD2)

DRE:	794199(setd2)

SRX:	107743179 107752833

SANH:

107673014 107685560

SGH:	107581536 107596709

CCAR:

109063165

CAUA:

113060209 113116306

CGIB:

127969714 127975534 128030804

PTET:

122360104(setd2)

LROH:

127178249(setd2)

OMC:	131521470(setd2)

PPRM:

120484453(setd2)

RKG:	130070181(setd2)

MAMB:

125243135(setd2)

CIDE:

127497709

MASI:

127454335

TROS:

130557516(setd2)

TDW:	130432613(setd2)

MANU:

129447809(setd2)

IPU:

108267177

IFU:	128608990(setd2)

PHYP:

113542507(setd2)

SMEO:

124384161(setd2)

TFD:	113644580(setd2)

TVC:	132845981(setd2)

AMEX:

103039344(setd2)

CMAO:

118825674(setd2)

EEE:	113570706(setd2)

TRU:	101076040(setd2)

TFS:	130532370(setd2)

TNG:	GSTEN00034080G001

LCO:	104940331(setd2)

NCC:	104948745(setd2) 104957630

TBEN:

117480208(setd2)

CGOB:

115021807(setd2)

PGEO:

117460444(setd2)

GACU:

117554101(setd2)

EMAC:

134861484(setd2)

ELY:	117265736(setd2)

EFO:	125893649(setd2)

PLEP:

121945864(setd2)

SLUC:

116049433(setd2)

ECRA:

117945702(setd2)

ESP:	116690678(setd2)

PFLV:

114557737(setd2)

GAT:	120810650(setd2)

PPUG:

119197772(setd2)

AFB:	129109168(setd2)

CLUM:

117745025(setd2)

PSWI:

130212725(setd2)

MSAM:

119897705(setd2)

SCHU:

122881330(setd2)

CUD:	121513186(setd2)

ALAT:

119006696(setd2)

MZE:	101471514(setd2)

ONL:	100689872(setd2)

OAU:	116325355(setd2)

OLA:	101163764(setd2)

OML:	112143951(setd2)

CSAI:

133430454(setd2)

XMA:	102216591(setd2)

XCO:	114141991(setd2)

XHE:	116717187(setd2)

PRET:

103478611(setd2)

PFOR:

103152270(setd2)

PLAI:

106939758(setd2)

PMEI:

106906609(setd2)

GAF:	122831473(setd2)

PPRL:

129371146(setd2)

CVG:	107081814(setd2)

CTUL:

119772867(setd2)

GMU:	124865731(setd2)

NFU:	107395695(setd2)

KMR:	108241998(setd2)

ALIM:

106534862

NWH:	119409449(setd2)

AOCE:

111572050(setd2)

MCEP:

125016073(setd2)

CSEM:

103388382(setd2)

POV:	109633212(setd2)

SSEN:

122774466(setd2)

HHIP:

117777387(setd2)

HSP:	118113301(setd2)

SMAU:

118308029(setd2)

LCF:

108891907

SDU:	111236791(setd2)

SLAL:

111652786(setd2)

XGL:	120783986(setd2)

HCQ:	109518019(setd2)

SSCV:

125975337

SBIA:

133500905(setd2)

PEE:	133401664(setd2)

PTAO:

133479116(setd2)

BPEC:

110171513(setd2)

MALB:

109967312(setd2)

BSPL:

114843737(setd2)

SJO:	128366082(setd2)

SASA:

106593284 106593288 106606040

STRU:

115187660 115187661

OTW:	112243644(setd2)

OMY:	110520688(setd2)

OGO:	124019594(setd2)

ONE:

115115571

OKI:

109882680

SALP:

112076057(setd2)

SNH:	120031365(setd2)

CCLU:

121542611(setd2) 121542806

ELS:	105018749(setd2)

SFM:	108927425(setd2)

PKI:	111850417(setd2)

AANG:

118228444(setd2)

LOC:	102690042 102692025(setd2)

PSPA:

121312967 121314673

ARUT:

117394754 117400236

PSEX:

120515800(setd2)

LCM:	102359121(SETD2)

CMK:	103190896(setd2)

CPLA:

122548953(setd2)

HOC:	132815050(setd2)

LERI:

129714861(setd2)

PMRN:

116940988(SETD2)

LRJ:	133344877(SETD2)

BFO:

118405673

BBEL:

109461664

SCLV:

120341878

SPU:

578079

APLC:

110986919

SKO:

100369661

DME:	Dmel_CG1716(Set2)

DER:

6551019

DSE:

6618681

DSI:	Dsimw501_GD17127(Dsim_GD17127)

DYA:	Dyak_GE17076

DAN:

6505186

DSR:

110182093

DPO:

4814289

DPE:

6601763

DMN:

108156147

DWI:

6649260

DGR:

6557383

DMO:	Dmoj_GI12297

DAZ:	108614554 108619464

DNV:	108652260 108656778

DHE:	111593003 111598712

DVI:	6623058 6631536

CCAT:

101451112

BOD:

106625326

MDE:

101890762

SCAC:

106085109

LCQ:

111681651

LSQ:

119609561

ACOZ:

120955503

AARA:

120901301

AMER:

121600385

ASTE:

118505912

AAG:

5567362

AALB:

109408612 115262623

CQU:	CpipJ_CPIJ005876

CPII:

120415447

CNS:

116351884

BCOO:

119071869

AME:

100578450

ACER:

108000008

ALAB:

122717056

ADR:

102675627

AFLR:

100869667

BIM:

100746901

BBIF:

117216888

BVK:

117236413

BVAN:

117154574

BTER:

100652142

BAFF:

126925889

BPYO:

122576559

BPAS:

132914931

FVI:

122530569

CCAL:

108630194

OBB:

114872234

OLG:

117606783

MGEN:

117221020

NMEA:

116425768

CGIG:

122402982

SOC:

105208079

MPHA:

105837114

AEC:

105144959

ACEP:

105622474

PBAR:

105424427

VEM:

105570676

HST:

105190387

DQU:

106746542

CFO:

105253156

FEX:

115241758

LHU:

105678859

PGC:	109855296 109859218

OBO:

105278228

PCF:

106791962

PFUC:

122514802

VPS:

122636636

VCRB:

124429738

VVE:

124956047

NVI:

100123115

CSOL:

105368748

TPRE:

106658278

MDL:

103571067

CGLO:

123272973

FAS:

105267384

DAM:

107038915

AGIF:

122861068

CCIN:

107273288

TCA:

662406

DPA:

109538546

SOY:

115880694

CSET:

123311119

AGB:

108904757

LDC:

111509954

NVL:

108569124

APLN:

108732872

PPYR:

116170941

OTU:

111414067

BMOR:

101738271

BMAN:

114245967

MSEX:

115443705

BANY:

112054435

PMAC:

106718844

PPOT:

106101273

PXU:

106118300

PRAP:

110997817

ZCE:

119830521

HZE:

124645896

TNL:

113493169

SLIU:

111352338

OFU:

114349566

PXY:

105386651

API:

100165877

DNX:

107165146

AGS:

114124926

RMD:

113558505

BTAB:

109043976

CLEC:

106666752

HHAL:

106687689

NLU:

111044513

PHU:	Phum_PHUM463920

FOC:

113217561

TPAL:

117647380

ZNE:

110839808

CSEC:

111870608

BROR:

134532381

FCD:

110842413

DPX:	DAPPUDRAFT_319776

DMK:

116933542

DPZ:

124336714

PVM:

113817071

PJA:

122252384

PCHN:

125026494

PMOO:

119580308

HAME:

121869854

PCLA:

123771702

PTRU:

123507790

HAZT:

108675739

EAF:	111704656 111710256

LSM:

121122210

DSV:

119442541

RSAN:

119385912

RMP:

119165735

TUT:

107365578

DPTE:

113790692

DFR:

124496638

CSCU:

111621622

ABRU:

129963284

BGT:

106059019

GAE:

121387655

HRF:

124152167

HRJ:

124264750

CRG:

105325625

OED:

125678394

PMAX:

117317293

OBI:

106877592

OSN:

115232341

NVE:

5515716

EPA:

110241079

ADF:

107347448

AMIL:

114957186

PDAM:

113664166

SPIS:

111325620

DGT:

114517689

HMG:

100200309

SCE:	YJL168C(SET2)

SEUB:

DI49_2859

SPAO:

SPAR_J00460

AGO:	AGOS_AEL128C

ERC:

Ecym_8108

KLA:	KLLA0_A06600g

KMX:	KLMA_10383(SET2)

LTH:	KLTH0F04510g

VPO:	Kpol_2001p35

ZRO:	ZYRO0G18766g

CGR:	CAGL0C00297g

NCS:	NCAS_0I02880(NCAS0I02880)

NDI:	NDAI_0B00260(NDAI0B00260)

TPF:	TPHA_0A02720(TPHA0A02720)

TBL:	TBLA_0J01040(TBLA0J01040)

TGB:	HG536_0A02070

TDL:	TDEL_0G02090(TDEL0G02090)

KAF:	KAFR_0F01770(KAFR0F01770)

KNG:	KNAG_0C02410(KNAG0C02410)

ZMK:	HG535_0E05320

PPA:	PAS_chr1-4_0287

DHA:	DEHA2F09350g

PIC:	PICST_31672

PGU:	PGUG_01518

SPAA:

SPAPADRAFT_54781

LEL:	PVL30_003232(SET2)

CAL:	CAALFM_C210250CA(SET2)

CTP:	CTRG_02012

COT:	CORT_0C06550

CDU:	CD36_24310

CTEN:

CANTEDRAFT_99232

YLI:	YALI0E18260g

CLU:	CLUG_05142

CLUS:

A9F13_03g00924

CAUR:

CJI96_0002018

SLB:	AWJ20_4803(SET2)

PKZ:	C5L36_0E03630

BNN:	FOA43_000082

BBRX:

BRETT_001030

OPA:	HPODL_04982

SLUD:

SCDLUD_003961

NCR:	NCU00269(set-2)

NTE:	NEUTE1DRAFT122301(NEUTE1DRAFT_122301)

SMP:	SMAC_06682

PAN:	PODANSg5165

PBEL:

QC761_707710(SET2)

PPSD:

QC762_707710(SET2)

PPSP:

QC763_707710(SET2)

PPSA:

QC764_707710(SET2)

TTT:	THITE_2118632

MTM:	MYCTH_2304904

CTHR:

CTHT_0025760

MGR:

MGG_01661

PPEI:

PpBr36_01175

PGRI:

PgNI_03834

TMN:	UCRPA7_6330

SSCK:

SPSK_04901

FGR:	FGSG_05558

FPU:	FPSE_06149

FPOA:

FPOAC1_008105(SET2)

FVN:	FVRRES_08542

FVR:	FVEG_06937

FOX:	FOXG_09334

NHE:	NECHADRAFT_106311(SDG2102)

FFC:	NCS54_01035200

FKR:	NCS57_01028800

FMU:	J7337_009590(SET2)

TRE:	TRIREDRAFT_80732

TRR:	M419DRAFT_102653

MAW:

MAC_05010

MAJ:

MAA_03512

PCHM:

VFPPC_04392

CMT:

CCM_07296

AMUS:

LMH87_012234

PLJ:	VFPFJ_01310

PTKZ:

JDV02_007371(SET2)

VAL:	VDBG_08742

VDA:	VDAG_06403

CFJ:	CFIO01_08551

CLUP:

CLUP02_03652

CHIG:

CH63R_02703

SAPO:

SAPIO_CDS2938

ELA:	UCREL1_10278

PFY:	PFICI_08148

SSL:	SS1G_07089

BFU:	BCIN_10g05250(Bcset2)

MBE:

MBM_00950

PSCO:

LY89DRAFT_192605

GLZ:	GLAREA_11156

ANI:	ANIA_08825

AFM:	AFUA_5G06000

ACT:	ACLA_009270

NFI:	NFIA_037130

AOR:	AO090009000660

AFV:	AFLA_010711

ALUC:

AKAW2_70806S(SET2)

ACHE:

ACHE_20468S(SET2)

APUU:

APUU_70399A(SET2)

PCS:	N7525_008569

PDP:	PDIP_22700

POU:	POX_e06283

TMF:	EYB26_004564

TRG:	TRUGW13939_07997

CIM:	CIMG_06210

CPW:	CPC735_027520

URE:	UREG_04172

PBL:	PAAG_04957

PBN:	PADG_02690

ABE:

ARB_07003

TVE:

TRV_02085

BGH:	BDBG_08436

PNO:	SNOG_01198

PTE:

PTT_20031

BZE:	COCCADRAFT_95981

BSC:	COCSADRAFT_258710

BOR:	COCMIDRAFT_7357

AALT:

CC77DRAFT_268428

ARAB:

EKO05_0008536

ZTR:	MYCGRDRAFT_20674(SDG2404)

PFJ:	MYCFIDRAFT_83386

FFU:	CLAFUR5_03324

CBET:

CB0940_03419

BCOM:

BAUCODRAFT_481348

TML:	GSTUM_00006511001

SPO:	SPAC29B12.02c(set2)

SOM:	SOMG_02428(set2)

CNE:

CNG03810

CNB:

CNBG0940

CNG:	CNAG_03188

CGI:	CGB_G1260C

CDEU:

CNBG_2397

TMS:	TREMEDRAFT_25563

TASA:

A1Q1_01839

CCAC:

CcaHIS019_0203370(SET2)

TVS:	TRAVEDRAFT_128498

DSQ:	DICSQDRAFT_111705

PCO:	PHACADRAFT_211907

SHS:	STEHIDRAFT_82382

HIR:	HETIRDRAFT_155759

PSQ:	PUNSTDRAFT_54761

ADL:	AURDEDRAFT_114444

FME:	FOMMEDRAFT_105290

GTR:	GLOTRDRAFT_41048

RSX:	RhiXN_09123

LBC:	LACBIDRAFT_318928(SDG16202)

CCI:	CC1G_09124

ABP:	AGABI1DRAFT123473(AGABI1DRAFT_123473)

ABV:	AGABI2DRAFT76781(AGABI2DRAFT_76781)

MRR:	Moror_6735

E1B28_013634

SCM:	SCHCO_01133652(SCHCODRAFT_01133652)

CPUT:

CONPUDRAFT_146442

SLA:	SERLADRAFT_359892

WSE:	WALSEDRAFT_45956

WIC:	J056_002605

UMA:	UMAG_02500

PFP:	PFL1_01834

SGRA:

EX895_004753

MGL:

MGL_3860

MRT:

MRET_0662

MSYM:

MSY001_2296

PGR:	PGTG_09875

PTRC:

PtA15_13A377

PSTR:

Pst134EA_017587

MLR:	MELLADRAFT_78094

» show all

Reference

1 [PMID:11839797]

Authors

Strahl BD, Grant PA, Briggs SD, Sun ZW, Bone JR, Caldwell JA, Mollah S, Cook RG, Shabanowitz J, Hunt DF, Allis CD

Title

Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.

Journal

Mol Cell Biol 22:1298-306 (2002)
DOI:10.1128/mcb.22.5.1298-1306.2002

Sequence

[sce:YJL168C]

Reference

2 [PMID:12917322]

Authors

Landry J, Sutton A, Hesman T, Min J, Xu RM, Johnston M, Sternglanz R

Title

Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.

Journal

Mol Cell Biol 23:5972-8 (2003)
DOI:10.1128/mcb.23.17.5972-5978.2003

Sequence

[sce:YJL168C]

Reference

3 [PMID:16087749]

Authors

Morris SA, Shibata Y, Noma K, Tsukamoto Y, Warren E, Temple B, Grewal SI, Strahl BD

Title

Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe.

Journal

Eukaryot Cell 4:1446-54 (2005)
DOI:10.1128/EC.4.8.1446-1454.2005

Sequence

[spo:SPAC29B12.02c]

Reference

4 [PMID:20048053]

Authors

Lin LJ, Minard LV, Johnston GC, Singer RA, Schultz MC

Title

Asf1 can promote trimethylation of H3 K36 by Set2.

Journal

Mol Cell Biol 30:1116-29 (2010)
DOI:10.1128/MCB.01229-09

Sequence

[sce:YJL168C]

Reference

5 [PMID:15798214]

Authors

Kizer KO, Phatnani HP, Shibata Y, Hall H, Greenleaf AL, Strahl BD

Title

A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.

Journal

Mol Cell Biol 25:3305-16 (2005)
DOI:10.1128/MCB.25.8.3305-3316.2005

Reference

6 [PMID:19332550]

Authors

Yuan W, Xie J, Long C, Erdjument-Bromage H, Ding X, Zheng Y, Tempst P, Chen S, Zhu B, Reinberg D

Title

Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.

Journal

J Biol Chem 284:15701-7 (2009)
DOI:10.1074/jbc.M808431200

Reference

7 [PMID:22266761]

Authors

Wagner EJ, Carpenter PB

Title

Understanding the language of Lys36 methylation at histone H3.

Journal

Nat Rev Mol Cell Biol 13:115-26 (2012)
DOI:10.1038/nrm3274

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.359

IUBMB Enzyme Nomenclature:

2.1.1.359

ExPASy - ENZYME nomenclature database:

2.1.1.359

BRENDA, the Enzyme Database:

2.1.1.359

DBGET integrated database retrieval system